Andy Hong

#physician #Pediatrics for kids with cancer with a research focus on #cancerresearch #ChildhoodCancer #kidneycancer #RareDiseases

[Dr. Anthony Letai @NCIDirector]

As we observe #ChildhoodCancerAwarenessMonth, let’s honor the children we’ve lost and recognize the bravery and resilience of those facing cancer.

Join me in our fight against childhood cancer and supporting these courageous children and families. #CCAM #ChildhoodCancer

[Michael Ortiz @MichaelVOrtiz]

I’m hosting the 12th international pediatric renal tumor biology symposium at MSK in NYC on June 5-7 with @oleg8r and the @COGorg & @WorldSIOP kidney tumor group leads; #Wilms #Rhabdoid #RCC ; Free registration and abstract submission until April 1 here:
https://t.co/JwS3i8uT2r

[Rare Cancer Research Foundation + Pattern.org @RareCancerRF]

We empower patients with #rarecancers to donate their tissue to research happening at leading institutions + labs through our platform https://t.co/wlPafYimhs.

Some of our partners are @MDAndersonNews, @kochinstitute & @DanaFarber, @broadinstitute, @BrighamWomens, @ATLPedsHemOnc

[Andy Hong @AndyHongMD]

Proud mentor moment: getting to see your trainees succeed! Congrats @GarrettC00per with your NCI F31 NOA! @emorygmb @ATLPedsHemOnc

[Alison M. Taylor @alisontaylorlab]

Out @Nature today! Excited to finally share our work led by Juliann Shih in collab w/ @RameenBeroukhim. Our algorithm “BISCUT” looks at large chromosomal changes and aneuploidy in cancer to detect genes that can account for effects on cellular fitness.
https://t.co/6Z33wBX379

[Nicky Whiffin @nickywhiffin]

What is an exon???

New paper w/ @ewjwallace and @RNA_julie in @CellGenomics : https://t.co/9EdQMf1bql

Cue 🧵1/8

[Tanaz Sharifnia @TSharifnia]

Now online @NatureComms: our study describing an expanded map of genetic dependencies in #chordoma, revealing new potential therapeutic targets (e.g., SHP2). Very special thanks to @SchreiberStuart, Mathias Wawer, and @ChordomaFDN!

https://t.co/mT9BbD6RNU

[Hao Zhu Lab @Zhu_Lab]

Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: https://t.co/Vu1d4U3stc 1/10

[Oana Ursu (@[email protected]) @oana__ursu]

Paper alert! 🚨 Studying the mSWI/SNF chromatin remodeling complex, by single and combinatorial Perturb-seq and SHARE-seq!

Incredibly fun joint work with Jordan Otto Jagielski (her PhD thesis!) and @alexpywu, collab between Regev and @CKadoch labs! 1/n

https://t.co/n7iqCad1se

[Choudhary Lab CPR @ChoudharyLabCPR]

H3K27ac has been the go-to hallmark of enhancers for over a decade, but what if another chromatin feature exceeds this in predicting enhancers?
Our paper was just published @NatureGenet https://t.co/H3AVVDlE1m
Congrats to @TakeoNarita80, Yoshiki and the rest of the team.

[Jonathan Pritchard @jkpritch]

Sharing this in case it's useful: I find that students often have a hard time conceptualizing quantitative parameters in genomics and popgen

Here's a cheat-sheet I put together for teaching. It's also part of a textbook I have been writing on human genetics (more on that below)

[Nature Methods @naturemethods]

It's finally here!! Our Method of the Year 2022 is....long-read sequencing! 🎉

Read our (free!) Editorial to learn why we felt the time was right to select this class of powerful technologies as the Method of the Year.
https://t.co/shnaRqYIxx

[Harmit S. Malik @HarmitMalik]

The field of chromatin biology lost a giant with the passing of David Allis. His science achievements & mentoring record are both stunning. He had a remarkable ability to make personal connections & mentor; he shared some insights into his approach here: https://t.co/vCsCQpkxZ6

[Kristin Knouse @kristinknouse]

Thrilled to share our lab’s first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal.

https://t.co/f8X154N7eh

[Evonne McArthur @EvonneMcArthur]

At the end of a great @GeneticsSociety #ASHG22, I wanted to share & get feedback on my "cheatsheet" of online resources, tools, and databases.

This was developed with @capra_lab collabs 🙏and at VUMC medical genetics. Please comment/message to add 💡!

https://t.co/f9q8uSukyr

[Leslie Vosshall PhD @leslievosshall]

We're doing a thing! Speakers @HHMINEWS Science Meetings will no longer put journal names on their talk slides.
Instead display first author, year, PMID (or DOI) like @ardemp
Why?
-end prestige-signaling
-people can actually find reference
#nojournalnamesontalkslides

[The New York Times @nytimes]

Dr. Audrey Evans, a pediatric oncologist who helped create the first Ronald McDonald House, a concept that has blossomed into a worldwide network, has died at 97. https://t.co/g4cWEBkvUG

[Lowe Lab @LoweLabMSKCC]

Out in @Nature today, we report that #p53 loss unleashes an ordered & selective pattern of cancer #GenomeEvolution: https://t.co/dAQK0qYLsJ. 1/n

[Jacob Schreiber @jmschreiber91]

🛑KEY POINT, READ THIS🛑 If you are dealing with collections of data, particularly those that span a long period of time, differences in processing like this WILL confound your results. You MUST make sure the data is uniformly processed or your results will likely be invalid. 13/

[Jessica Tsai, MD, PhD @jestsai]

Excited to share our new work on FOXR2 as an epigenetically activated pan-cancer oncogene in @AACR Cancer Research - a wonderful collaboration between @Bando_Lab, the Phoenix Lab, and @dtwjones