Philip Brown

GS4 MD/PhD in Reynolds Lab @ UTSW. Previously: IRTA fellow Rotman Lab @ NIH ‘18 | BS @ Cornell University ‘16 - statements here are my own

[Nature Communications @NatureComms]

@kimreynolds_lab based @UTSWMedCenter show that biochemical coupling between metabolic enzymes shapes the range of enzyme activities sufficient to rescue cell growth

https://t.co/eFjUMa0Xnt

[TheRealZigmanLab @ZigmanLab]

A long-acting #LEAP2 agonist as a new treatment for #MAFLD #fattyliver and #obesity ? @oceankripa and the rest of the @ZigmanLab say YES! #ghrelin

https://t.co/LPcHwylKW5
preprint now available @MolMetab

@UTSWMedCenter @UTSWInternalMed @UTSWBrain @UTSWdiabetes

[Kim Reynolds @kimreynolds_lab]

Physical protein interactions constrain interface sequence. But what about non-binding "biochemical" interactions in metabolism? We used deep mutational scanning to map sequence constraints for two enzymes that catalyze consecutive metabolic reactions: https://t.co/avrfd23Zs8

[Scott Saunders @s_h_saunders]

The “ORBIT for E. coli” paper is out in Nucleic Acids Research! https://t.co/v4HvqMl3NB

**Perform genetics (e.g. deletions) without any PCR / cloning – just transform an oligo!**

The paper demonstrates benefits over λ Red & shows how oligos scale to high throughput libraries.

[Philip Brown @B3Phil]

@E_L_Isenstein @JohnnyFoxe CONGRATS!!!

[Yaron Rotman @NASH_and_coffee]

Our @NIDDKgov lab is seeking a #postdoc for exciting project assessing how human #liver in #MASLD handles fasted-to-fed transition.

Unicorns comfortable with bioinformatics, molecular biology and physiology should apply.

Details 👇

Friends please RT!

https://t.co/ugwUtsOkBK

[Philip Brown @B3Phil]

Proud to share our recently published work from @kimreynolds_lab! Ever wanted to quantify epistatic relationships between genes? Here’s our proposed model in E. Coli!

A continuous epistasis model: Cell Systems https://t.co/Diq7BV9zGw

#UTSW #genetics #systemsbiology #mstp

[UTSW 3MD Graduate Track @UTSW3MD]

Goood (late) morning! This is Phil Brown (@B3Phil) here - long time metabolism fan, and current student in the Molecular Metabolism & Metabolic Disease Track! I’m at the controls of the UTSW3MD Twitter (X?) account today - so I’ll share about myself and a day in the life of 3MD!

[Cell Metabolism @Cell_Metabolism]

Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism https://t.co/ITcGWZlSxY

[Scott Saunders @s_h_saunders]

Our 1st preprint!

We developed a genetic toolkit for E. coli that directly uses cheap DNA oligos to specify kb scale mutations. No PCR/cloning to delete genes!

The paper demonstrates benefits over λ Red & gets fancy w/ pooled mutant libraries. 1/15

https://t.co/8QvDOqliqo

[Sam Scarpino @svscarpino]

I always carb load before bioinformatics.

[UTSW Graduate School of Biomedical Sciences @UTSWGradSchool]

Congratulations to @ginajpark on receiving the 2023 Ida M. Green Award! In her dissertation research, Gina discovered the mechanism of mRNA capping by SARS-CoV-2, involving a novel reaction catalyzed by a pseudokinase domain. Congratulations, Gina!

[UTSW 3MD Graduate Track @UTSW3MD]

We are so proud of @VancityReynolds ...well not that Ryan Reynolds, but our Ryan Reynolds on his PhD thesis defense today.

[UTSW 3MD Graduate Track @UTSW3MD]

#MetabolismMasterclass today at 4PM
Today's speaker is Dr. Joachim Herz.
"Preventing Alzheimer’s – Novel Mechanisms and Therapeutic Approaches"

@UTSWGradSchool @UTSWmstp @UTSW_NeuroGrads @UTSWNeurosci @UTSWNeurology

[UTSW 3MD Graduate Track @UTSW3MD]

#Metabolize with us on Thu 3/9 5pm at "Bottles & BS".
Organized by @UTSW3MD's Social Committee.
Faculty Guest Dr. Markey McNutt.
Food is on us!
@UTSW3MD @UTSWGradSchool @GDDgradprogUTSW @UTSWmstp @UTSW_NeuroGrads @UTSWCancerBio students are invited.

[UTSW 3MD Graduate Track @UTSW3MD]

@UTSWGradSchool @GDDgradprogUTSW @UTSWmstp @UTSW_NeuroGrads @UTSWCancerBio @CmbUtsw students this is for you. "Bottles & BS". Brought to you Thursday 2/16 6pm. Hosted by @UTSW3MD's Social Committee with @B3Phil. See you there!! #metabolize with us at @on_rotation. Food is on us.

[GD&D @GDDgradprogUTSW]

Group Photo!!! #GDDRetreat2023

[Jenny Goldstein @JennyElaineG]

Cornell is increasing grad stipends to $43k for next year, requiring summer funding to be provided for all PhD students, cutting grad tuition costs for private Cornell colleges cause they are currently higher than the public ones

[Kim Reynolds @kimreynolds_lab]

I recently learned that my tenure application was approved!! So grateful to all the fantastic students, fellows, and staff that I've had the privilege of working with. What a great lab team. And excited for what comes next! @MolBiophysUTSW @LHBioinf_UTSW @UTSWcomps

[Nature Metabolism @NatMetabolism]

RESEARCH | Led by Jian Xu (@UTSWNews):

The authors provide insight into the regulation of branched-chain amino acid #metabolism and its impact on whole-body physiology by identifying and characterizing a metabolon formation.

https://t.co/oY1AvM3ACL