BISWADEEP GHOSH ROY

| Doctoral Student |
| Area of Interest: Cancer Immunotherapy |
| UKD Dusseldorf |
| Institute of Molecular Medicine II |

[BISWADEEP GHOSH ROY @BISWADE26329340]

Excited to share my latest research publication in my PhD!
Our new study, titled "An Engineered Palivizumab IgG2 Subclass for Synthetic gp130 and Fas-Mediated Signaling," has been published in the Journal of Biological Chemistry.

Read the full paper here:
https://t.co/Kv77lVnVTf

[nature @Nature]

Nature research paper: Intestinal stem cells count self-renewal divisions to switch multipotency

https://t.co/kmp6FkPLIS

[Science Magazine @ScienceMagazine]

On a cloudy day in January, historian Ivan Malara sat in Italy’s National Central Library of Florence poring over seven 16th century printings of the ancient world’s most influential astronomy text. The pages belonged to The Almagest, in which second century polymath Claudius Ptolemy described his vision of an Earth-centered cosmos.

As Malara flipped through the pages, he spotted something out of place. Someone had transcribed Psalm 145 on an otherwise blank page—in handwriting reminiscent of a very, very famous Tuscan astronomer.

That book, Malara came to realize, had been extensively annotated by none other than Galileo Galilei.

Malara’s discovery, described in a paper now under review, promises new insights into one of the most famous ideological transitions in the history of science: the moment when Earth was thrust from the center of our universe.

Learn more: https://t.co/KI66MpLCXG

[nature @Nature]

Nature research paper: Small-molecule modulation of β-arrestins

https://t.co/lq8WQmtMeX

[Zihai Li, MD, PhD @Zihai]

https://t.co/Mllcq86k7m

[Cancer Discovery @CD_AACR]

Now online: Blockade of Tumor-Intrinsic TGFβ Signaling Drives Hyperprogression in Small Cell Lung Cancer https://t.co/5gBeRnZdqv

[Science Translational Medicine @ScienceTM]

A landmark study shows that latent #HIV can convert CD4+ T cells to CD8+ T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. @sysu_1924 https://t.co/y5F63thTkm

[Cameron McAlpine @cam_phd]

We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis.

https://t.co/pzksoeQ9xG

[Saligrama lab_WUSTL @SaligramaLab]

for those who #dont #believe in the #existence of #CD8 #Regulatory #cells -here is a #clear #evidence -they #DO exist and are #regulatory https://t.co/XeMV7SlWi5

[Ryuta Koyama @ryuta_koyama]

Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair: Cell Reports https://t.co/MmxRteABVZ

[Ansu Satpathy @Satpathology]

A holy grail for our lab has been tracking myeloid cells in human tumors in the same way that we track T and B cells with TCR/BCR.
@vincentzliu and @CalebLareau solved it!
We developed Mitotrek using scATAC-seq + mitochondrial DNA to do exactly this. Using Mitotrek, we find that new myeloid cells clones constantly infiltrate the tumor via circulating monocytes — and that their macrophage or dendritic cell fate is epigenetically programmed before tumor entry.
@10xGenomics @parkerici @CancerResearch @TheMarkFdn
https://t.co/Y37qbyw3F5

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[Eric Topol @EricTopol]

Another major advance vs cancer! @ASCO #ASCO26
Personalized neoantigen mRNA vaccine 5 year follow-up vs metastatic melanoma reduced recurrence and death by 49% (on top of Keytruda)
https://t.co/NadITTYIT2

[Charles Swanton @CharlesSwanton]

Online here: https://t.co/nzzWChWPkD
Open access here: https://t.co/MEUA5HUeGx
Key supporters of this work are @CR_UK , @CRUKLungCentre , @UCLHresearch alongside many others

[Science Magazine @ScienceMagazine]

Project Hail Mary follows an unlikely hero on a high-stakes journey to save humanity. Adapted from the book by Andy Weir, the film blends interstellar adventure with real-world science—an approach that sets it apart from many recent sci-fi blockbusters.

The premise may sound far-fetched, but the film grounds its story in disciplines ranging from astrophysics to microbiology, raising an intriguing question: Just how realistic is the science behind it?

To find out, Science spoke with Wendy Freedman, an astronomer at the University of Chicago who studies the evolution of the universe.

Read more: https://t.co/MoESBFrPnl

[Satya Nadella @satyanadella]

We’ve trained a multimodal AI model to turn routine pathology slides into spatial proteomics, with the potential to reduce time and cost while expanding access to cancer care.

[IIT Madras @iitmadras]

1 in 4 Indian breast cancer patients may carry an inherited genetic risk variant — and most of these lie beyond the widely tested BRCA genes.
A landmark study by @iitmadras and @karkinoshealth, in collaboration with Kumaran Hospital and Chennai Breast Centre, has revealed critical insights from one of India’s largest germline breast cancer datasets (479 patients). The study published in BMC Cancer and now part of the Bharat Cancer Genome Atlas, shows that 24.6% carried pathogenic variants, but only 8.35% were in BRCA1/2, while 67% of positive findings were in non-BRCA genes such as MLH1, TP53, NF1 and RB1.

Researchers also identified India-specific variants, RECQL population differences, and clinically significant DPYD variants linked to chemotherapy toxicity (impacting drugs like 5-FU and capecitabine).

The message is clear: India urgently needs multi-gene panel testing, ancestry-specific variant databases, pharmacogenomic screening, and precision oncology guidelines tailored to its population. This study lays the groundwork for exactly that.

Find the full study here: https://t.co/hO5DKCGAnM.

[IIT Madras, Karkinos Healthcare, Breast Cancer, datasets, chemotherapy, multi-gene testing, oncology]

[Adam KP @AdamKPx]

This is what learning looks like in spatial computing 👀

[Bo Wang @BoWang87]

I’m not an aging biologist, but I have to say — @davidasinclair is one of the clearest science communicators out there.

The way he explains aging really stuck with me:
it’s not just “damage,” it’s loss of biological information.
And in theory, information can be restored.

75% age reversal in animals in 6 weeks.
FDA-cleared human trial now underway.

Video source : @vitrupo

[Anirban Maitra @Aiims1742]

Very cool protein engineering @ScienceMagazine paper!
Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics
https://t.co/vnbFbEXg95
One can literally mix and match receptor combinations to enable customized effector signaling.

[The Better India @thebetterindia]

He won $3 million — nearly three times the Nobel Prize — and still chose a bicycle over a luxury car. 🚲

Meet Ashoke Sen, the Kolkata-born physicist whose work sparked the “second superstring revolution” and reshaped modern physics.

Despite global recognition, he returned to India, donated much of his prize money, and continues working from a simple office.

Proof that true greatness doesn’t chase noise — it moves quietly, with purpose.

#AshokeSen #IndianScientist #FundamentalPhysics #InspiringIndian #ScienceHeroes

[Ashoke Sen, Fundamental Physics Prize, Second Superstring Revolution, Sen Conjecture, Indian Theoretical Physicist, Award India]