Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: https://t.co/1AvK5l8CD0. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!
Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work!
https://t.co/EQNitlrMeX
Researchers from the Mattiroli group discovered that DNA packaging in cells can directly impact the speed of DNA copying during cell division. The packaging sends signals through an unusual pathway, affecting the cell’s ability to divide and grow. More: https://t.co/Fgv1RynmHK
Ready to establish your own research group at the Hubrecht Institute for molecular and developmental biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply!
https://t.co/hXb5jz43oG
How does genomic mosaicism arise during development? We identified that embryo patterning signals not only readour genetic blueprints to build organisms, but they also play a critical role in their maintenance. A quick dive into our new paper https://t.co/KCFxEFaERI 1/10
Ever wondered how stem cells ensure a balance between cell fates in the gut?⚖️Turns out, they’ve got rhythm!🎶Our latest research reveals that NOTCH-driven oscillations regulate stem/progenitor cell abundance and specify secretory subtypes. Check it out: https://t.co/qvEsbAbx5O
New scEdU-seq method developed by @AlexandervanOu1 group measures DNAreplication speed in individual cells & may provide new insights into DNAreplication, embryonic development & cancer. https://t.co/CN4hdtlZwi @jervdberg@BVincentv@Acebron@Anchel_91 @marcelvanvugt @RBTjeerdsma
Hes genes are dynamically expressed in many tissues. But how do dynamics differ between tissues and are they always oscillatory?
We have addressed this question in the context of the developing embryo, where somites and neural tube form side-by-side.
https://t.co/sj3gPFB9Ph
What happens when cells stop assemblying nucleosomes during DNA replication?
We used CAF-1-degron human cells to answer this question, and look at the immediate effects within a single cell cycle. 🧵⬇️
https://t.co/iZO5GHxc2N
Exhilarated to share our pre-print describing a novel method, scEdU-seq, to measure DNA replication forks and their speeds in singe cells. Many thanks to @AlexandervanOu1, @Bvincentv and others @_Hubrecht for making it happen!
https://t.co/hRTUBO3hPi