Bowen Zhang

PhD candidate at @rmkhokha lab in @MBPatUofT studying breast metabolism/epigenetics. Avid organoid-culturist. Chess enthusiast.

[Journal of Clinical Investigation @jclinicalinvest]

Can metalloproteinase inhibitors advance strategies for repopulating damaged tissues?

@rmkhokha & team @UHN discover natural protease inhibitors regulate the liver progenitor niche via sDLK1: https://t.co/n5OV123iP4

@PMResearch_UHN @OICR_news @CIHR_ICR @CCSResearch

[Ian Yen @IanYYen]

Happy to share my first PhD paper from @PLynneHowell lab with my fantastic post-doc mentor @gregbwhitfield from @BrunLabCaulo as well as @Dr_Lori_Burrows and @RubinsteinJohn with #cryoem support where we propose how the bifunctional Tad pilus motor works🧵 https://t.co/nWqKIn4zuK

[Nature Metabolism @NatMetabolism]

RESEARCH | Y Qiu, M Lukey et al. (@CHSL):

The study provides insight into the metabolic adaptations that enable breast cancer cells to proliferate in the face of glutaminolysis blockade.

#CancerResearch

https://t.co/JvCgfQSF4Y

[Peter Mothe @petermothe]

A small part of the group who made it out this morning to the #TFRI10SM Terry Fox Run!
As always, Terry guided the way!
@tfri_research @marathonofhope @TerryFoxCanada

[Canadian Cancer Society @cancersociety]

UPDATE: The Canadian Cancer Society is updating its position on breast screening to reflect evolving evidence and calls for action from patients who are frustrated that many women aged 40 to 49 are being excluded from breast screening as well as the national guidelines developed by the Canadian Task Force on Preventive Health Care.

We’re urging provinces and territories to lower the start age for breast screening programs to 40 for individuals at an average risk of developing breast cancer. Many provinces and territories have taken steps to expand access to this age group, and we applaud those actions.

Access to breast screening is important to find breast cancer early when chances of successful treatment are better.

Learn more about our new position on breast screening: https://t.co/brGGhWiUZm

[Hannah Harrison @DrHHarrison]

Really pleased to share our new in vitro model of the normal mammary gland.
https://t.co/vzpr9dTFxU

Thanks to all the authors, to the ladies who donated tissue through @MCRCBiobank and to @wearepreventBC for funding the work.

@MCRBreastCentre

[Thomas Kislinger @KislingerThomas]

Checkout our new paper, describing a simple method to analyze low amounts of flow sorted cells by @mrwaas and team

Droplet-based proteomics reveals CD36 as a marker for progenitors in mammary basal epithelium: Cell Reports Methods https://t.co/FXHzafuH6g

[Cell Stem Cell @CellStemCell]

Metabolic regulation of the hallmarks of stem cell biology https://t.co/djhhfeBw9W

[Bowen Zhang @B_Zhang117]

The Career Development Association @MBPatUofT would like to invite alumni/early career professionals for seminars to share their career journeys!

#uoft #uhn #careertalks

[MBPGSA at UofT @MBPGSA]

(4/4)Feel free to reach out to the MBPCDA at [email protected] if you have any questions! #universityoftoronto #medicalbiophysics #uoft #mbp #uoftmbp #uoftalumni

[Bowen Zhang @B_Zhang117]

Please check out @c_mccloskey1’s amazing work creatively leveraging scRNA-seq to discover and characterize a novel mammary progenitor population with implications for high-risk BRCA1 mutation carriers! Delighted and grateful for the opportunity to be a part of this project! 🙌

[Curtis McCloskey @c_mccloskey1]

Excited to share our discovery of an epithelial progenitor population in the human breast! FABP7+ ductal luminal progenitors have distinct and targetable metabolism, and are the projected root of aberrant differentiation in the BRCA1 breast. @rmkhokha 1/9
https://t.co/Ve1AHbwrsB

[Nature Reviews Cancer @NatureRevCancer]

NEW content online! Metabolic pathway analysis using stable isotopes in patients with cancer https://t.co/JmAoNq0Xbh

[Vuk Stambolic @LupoCiyuCy]

Excited to share our work “Insulin Receptor Loss Impairs Mammary Tumorigenesis in Mice“. Led by @LaurenMPodmore and @KatPlz, our study reveals a major function of INSR in breast/mammary tumour initiation, likely independent of its kinase activity.https://t.co/ErPwZ79ip2

[Cell Reports @CellReports]

Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages https://t.co/2NJU7NfXkX

[Breast Cancer Canada @BreastCancerCDN]

1 in 8 Canadian women will be diagnosed with breast cancer.

During the month of October, we need your help to generate awareness and raise funds for life-saving breast cancer research.

To register for or donate to the Raise More Challenge, please visit https://t.co/QG2qF5fYSz.

[Rama Khokha @rmkhokha]

An awesome day for the Terry Fox run, and so many families out with kids. MOMICs team folks ran at YYZ & YVR

[Matt Waas @mrwaas]

Introducing DROPPS!

Here's our preprint that describes an accesible approach to low input proteomics and how we applied it to generate some interesting biological insights (1/x)

https://t.co/cBhdAWgy4a

[The Boulton Lab @BoultonLab]

Our latest📰! Out today in @MolecularCell We used single-molecule imaging to directly observe human BRCA2 tumour suppressor in action! Spearheaded by @BelanOndrej & @LukeGreenhough. A thread. (1/10)
https://t.co/hfn2uWSoOw

[Organoid News @organoidscience]

What do leaders in their fields think about the present and future of #organoids?

Read key insights and watch presentations by Drs. Hans Clevers, Madeline Lancaster, Meritxell Huch, and more from this “Advances in Organoid Applications” Round Table.
https://t.co/jXzAGVxqaV

[FrezzaLab @FrezzaLab]

"The bidirectional relationship between metabolism and cell cycle control"
https://t.co/I9po6MyodO