Biophillic Research Institute

The Biophillic Research Institute is a non-profit dedicated to advancing life sciences. Retweets, posts and likes are not medical advice or endorsement.

[Dr. K, M.D. @DrKERMD]

Lots of misinformation I’m seeing on X regarding the peptide meeting today and what the recommendations actually mean.

Today’s PCAC votes (so far favorable for BPC-157 and KPV!) are advisory only.
A “yes” recommendation does not immediately allow compounding. The FDA still has to decide and complete formal rulemaking.

If the agency ultimately adds these peptides to the 503A Bulks List, licensed 503A pharmacies could compound them for patients under a valid prescription, with standard quality and sterility requirements.

Until that process finishes, nothing changes in current compounding restrictions.

The recommendations are a step toward a regulated pathway, not a green light (yet).

[Science Magazine @ScienceMagazine]

A prostaglandin prevents macrophages from clearing toxic neutrophils in aging organs, according to new Science research in mice.

Learn more in a new #SciencePerspective: https://t.co/JUjOXaPEpJ

[MTS @MTSlive]

SITUATION DETECTED: The White House Office of Science and Technology Policy has released a report directing federal research funding toward individual scientists and AI use rather than universities, per WSJ.

The directives will shape about $200B in annual federal R&D spending.

[Aging Science News @AgingBiology]

Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging
https://t.co/wLQRyh2RQa

[SciTech Era @SciTechera]

BIG ANTI-AGING BREAKTHROUGH

Scientists just reverse a key form of aging damage once thought permanent 🤯!

> Researchers engineered a novel enzyme called CMLase that repairs Advanced Glycation End Products (AGEs), harmful molecular damage that builds up in tissues as we age.

> In aged human artery tissue, the enzyme removed over 70% of accumulated CML damage. In elderly human skin, it reduced CML levels to those seen in approximately 30-year old skin.

> AGEs stiffen arteries, weaken skin, and damage the extracellular matrix (ECM), the structural scaffold that supports our cells. They were long considered irreversible.

> This is the first evidence that a major AGE can be enzymatically repaired in human tissue, opening a new path toward structural rejuvenation alongside cellular anti-aging therapies.

welcome to the fastest accelerating SciTech Era ♥️ 🫡!

[Lifespan News @LifespanNews]

A new study associated with Immorta Bio suggests combining a senolytic vaccine with mesenchymal stem cells might create a synergistic impact. The findings rest on acute, artificially induced injury models.

👉 Read more: https://t.co/KVAk1R2pGy

[Medical Xpress @medical_xpress]

Across 182 species, bigger limbic systems consistently came with smaller neocortices, pointing to an evolutionary trade-off in brain wiring rather than a battle between “logical” and “lizard” brains. @georgiatech @ScienceAdvances https://t.co/QlgJjkDuif

[Andrew Dunn @AndrewE_Dunn]

NEW: Anthropic announces it is developing its own preclinical drug programs

No specifics provided beyond a focus on neglected diseases

"To build the right models, products and tools, we need to live it along with all of you," Eric Kauderer-Abrams, Anthropic life sci head, says

[Lifespan News @LifespanNews]

Researchers have found that sustained expression of excess hypoxia-inducible factor (HIF)-1α leads to unwanted formation of blood vessels (angiogenesis) that destroys cartilage and causes osteoarthritis.

👉 Read more: https://t.co/1RgX2nKEMW

[Medical Xpress @medical_xpress]

Arc appears to be essential for toxic Tau to spread in mice; without it, Tau transfer in brain vesicles was almost gone, while the same vesicles also show up in human brain tissue. @uofuhealthcare @CellCellPress https://t.co/eJwm0HxIjF

[Colby Serpa💡 @ColbySerpa]

From C60 to B80!

[Biophillic Research Institute @BiophillicLife]

Opioid Abuse Leads to Demyelination

"Oligodendrocytes, the myelin-producing cells of the central nervous system, are highly affected by chronic opioid exposure, as opioids can directly induce apoptosis of myelinating oligodendrocytes after activation of opioid receptors, leading to an important reduction in myelination."
https://t.co/9ndS3S8Y8Y

[Anthropic @AnthropicAI]

New Anthropic Science Blog: Making Claude a chemist.

To manipulate a molecule, chemists first need to understand its structure. Their main tool is NMR spectroscopy.

We found Opus 4.7 matches—and on some tasks beats—dedicated NMR software. Read more: https://t.co/1jUvz7wdhV

[OpenAI @OpenAI]

We’re bringing new capabilities to GPT-Rosalind, a model series purpose-built for life sciences research at enterprise scale.

It brings GPT-5.5’s agentic coding and tool use together with stronger intelligence for drug discovery, analysis, design, and experimental workflows.

https://t.co/SrAJ3Mt7ka

[Phys.org @physorg_com]

The jump from one cell to many may have started with physics: crowding and compression can push cells toward a few recurring shapes that scale into tissues. @Caltech @NatureBiotech https://t.co/5sWI8EdtBN

[Phys.org @physorg_com]

In a test tube, coronavirus evolution sprinted from the original strain toward an omicron-like form in just months—but only under one lab condition. @NatureComms https://t.co/NkMJjw6Uc8

[Medical Xpress @medical_xpress]

An experimental molecule pushed microglia back toward beta-amyloid plaques, where they began enclosing the deposits instead of failing around them. @UniversidadMH https://t.co/BSVMHsb4ti

[Medical Xpress @medical_xpress]

Inside neurons, tau clumps may unlock normally silent DNA elements and start a chain that ends in cell death. @NatureNeuro https://t.co/crHO86TnYu

[Biophillic Research Institute @BiophillicLife]

@jack Longevity jack is the best jack.

[Medical Xpress @medical_xpress]

At the edge of melanoma tumors, a little-noticed immune cell was caught engulfing live cancer cells in real time. @JExpMed https://t.co/SLdDvXVSAp