Blake Sells

MD/PhD Student, Washington University in St. Louis. Metabolism, cancer, infectious diseases, and global health @WUSTLmstp Trainee in the DeNardo Lab

[Science Immunology @SciImmunology]

A dual therapy that targets conventional #dendritic cells can boost T cell-mediated antitumor immunity in #PancreaticCancer, according to a new study involving patient samples and mice. @DeNardoLabWUSM

Learn more in Science #Immunology: https://t.co/xHy49LnS8k

[David DeNardo WUSM @DeNardoLabWUSM]

Congratulations Dr. Hogg and team @SciImmunology: #dendritic cells can matter in #PancreaticCancer, patients. See it at https://t.co/H1qM3Sx9Vy
Big thanks to Swim Across America @SAA_Inc St. Louis and Pedal the Cause @pedalthecause for supporting this research and trial.

[Samantha Morris @morris_lab]

Skin fat plays by its own rules.
We trace lineages (CellTagging), classify cell identity (Capybara), and model fate decisions (CellOracle) in our new Cell Stem Cell paper.
It’s not a linear path.
🔗 https://t.co/8MJXU7Vd0Q

[Vinod BalachandranMD @TheVinodLab]

1. Tertiary Lymphoid Structures (TLSs) – on demand lymphoid aggregates that assemble in inflamed tissues/cancer to regulate immunity

But how? What molecule triggers? What cells induce?

TODAY in @Nature https://t.co/vTh33onmjh

Long-term #PDAC survivor PART4 – TLSs

🧵1/25

[Anirban Maitra @Aiims1742]

New @NatureCancer paper from @SearsRosie @coussens_lisa and colleagues @OHSUKnight address the clinical question of why patients with #PancreaticCancer associated with lung only metastatic disease have a better prognosis than liver metastases. The answer lies in the ability to tolerate replication stress and the limited T cell immune response that accompanies such tolerance.

[Ruffell Lab @Ruffell_Lab]

Thrilled to share our story out in Cancer Cell, led by the amazing Kay Hanggi (now on the job market). We show that necrotic forms of cell death and the subsequent release of IL1a drives myeloid-based immune suppression in models of breast cancer. (1/11)

https://t.co/7cafJW2KSQ

[Kalluri Lab @KalluriLab]

Many thanks to @DeNardoLabWUSM for their spotlight article on our cDC1 vaccine.

👉https://t.co/2d6N2wp5jO

ICYMI: our work in @ScienceMagazine by @krishnaniyer199 and colleagues: cDC1 vaccine facilitates curative immunotherapy in PDAC.

👉 https://t.co/LqUcdUx1SG

[Nature Metabolism @NatMetabolism]

RESEARCH | R Nakai, T Yokota, J Brestoff et al. (Osaka Univ, JPN; @washu_pathology)

Administration of exogenous #mitochondria 💉or mitochondrial transfer from wild-type mice improves morbidity and mortality in a mouse model of #Leighsyndrome🐁

https://t.co/leWzOeET9U

[Allison Rosenzweig @arosenzweig19]

Exciting to see this publication come out of the @PanCAN Therapeutic Accelerator Collaborative Awards - exactly what we set out to do. https://t.co/2cqJmpD2un

[Anirban Maitra @Aiims1742]

New @ScienceTM paper from @DeNardoLabWUSM (with @LabBeatty @bryant_kl & @VerastemOncolog)
Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve #PancreaticCancer responses to cytotoxic and immune therapy
https://t.co/qJDDbJHvzH

[David DeNardo WUSM @DeNardoLabWUSM]

Congratulations Dr. Liu @SitemanCenter and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM . And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology.

[David DeNardo WUSM @DeNardoLabWUSM]

Congratulations Dr. Liu and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM. And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology

[Science Magazine @ScienceMagazine]

A new generation of cancer-preventing vaccines could wipe out tumors before they form.

Learn more: https://t.co/pilczKPfCG @NewsfromScience #ScienceMagArchives

[Samantha Morris @morris_lab]

Congratulations @mle_butka on a successful PhD defense today! 🎓🍾

[Linghua Wang, MD, PhD @IamLinghua]

@NCIsysbio A6: A study by @ItaiYanai & team shows tumor cells adapt to anticancer drug treatments by a series of cellular state transitions, each inducing distinct gene expression programs. They utilized scRNA-seq, ST, systematic genetic perturbations, ML techniques
https://t.co/hp1BnFi52a

[Waggoner Lab @LabWaggoner]

Deep Metabolic Profiling of Immune Cells by Spectral Flow Cytometry – A Comprehensive Validation Approach
https://t.co/RPlwgbPyzg

[Waggoner Lab @LabWaggoner]

[1/2] IFNγ produced by γδ T cells stimulates ⬆️pancreatic β cells glucose-induced insulin release that ⬇️hepatic glucose output that ⬆️IFN-I levels by curtailing lactate inhibition of IRF3 & NF-κB signaling to aid responsiveness to viral pathogens
https://t.co/goVGALsrDP

[Samuel Hume @DrSamuelBHume]

Intriguing paper in this week's Science: a new, much cheaper approach for MRI scanning

It's an MRI scanner that uses a 0.05 Tesla magnet (vs. the current 1.5 - 3 T) and operates at a fraction of the cost (~$22,000 for the hardware), time (<10 minutes), and noise of a current MRI scanner

Unlike current MRIs, the prototype scanner plugs into a standard wall socket, and doesn't need specialist shielding equipment

It uses a deep learning (AI) strategy to improve the low signal-noise ratio that's inherent to lower field strength MRIs

Although the images from the 0.05 T approach aren't as good as from 3 T MRI, they don't seem to be far off

Zhao et al: https://t.co/Fj1C1mWVc5

[Anirban Maitra @Aiims1742]

“Fungi in cancer” on the cover of Nature Reviews Cancer.
Perspective below:
https://t.co/eWcU3t2i1e

[Anirban Maitra @Aiims1742]

Cool “bugs as drugs” preprint from @KenOliveLab to start off your Monday. Really great stuff Ken (who is on a roll!)
Tumor-selective treatment of metastatic #PancreaticCancer with an engineered, probiotic living drug
https://t.co/916Lm9HeoC
Photomicrograph showing acylhomoserine lactone activated engineered bacteria localized within primary & metastatic disease sites.