A dual therapy that targets conventional #dendritic cells can boost T cell-mediated antitumor immunity in #PancreaticCancer, according to a new study involving patient samples and mice. @DeNardoLabWUSM
Learn more in Science #Immunology: https://t.co/xHy49LnS8k
Congratulations Dr. Hogg and team @SciImmunology: #dendritic cells can matter in #PancreaticCancer, patients. See it at https://t.co/H1qM3Sx9Vy
Big thanks to Swim Across America @SAA_Inc St. Louis and Pedal the Cause @pedalthecause for supporting this research and trial.
Skin fat plays by its own rules.
We trace lineages (CellTagging), classify cell identity (Capybara), and model fate decisions (CellOracle) in our new Cell Stem Cell paper.
It’s not a linear path.
🔗 https://t.co/8MJXU7Vd0Q
1. Tertiary Lymphoid Structures (TLSs) – on demand lymphoid aggregates that assemble in inflamed tissues/cancer to regulate immunity
But how? What molecule triggers? What cells induce?
TODAY in @Nature https://t.co/vTh33onmjh
Long-term #PDAC survivor PART4 – TLSs
🧵1/25
New @NatureCancer paper from @SearsRosie@coussens_lisa and colleagues @OHSUKnight address the clinical question of why patients with #PancreaticCancer associated with lung only metastatic disease have a better prognosis than liver metastases. The answer lies in the ability to tolerate replication stress and the limited T cell immune response that accompanies such tolerance.
Thrilled to share our story out in Cancer Cell, led by the amazing Kay Hanggi (now on the job market). We show that necrotic forms of cell death and the subsequent release of IL1a drives myeloid-based immune suppression in models of breast cancer. (1/11)
https://t.co/7cafJW2KSQ
Many thanks to @DeNardoLabWUSM for their spotlight article on our cDC1 vaccine.
👉https://t.co/2d6N2wp5jO
ICYMI: our work in @ScienceMagazine by @krishnaniyer199 and colleagues: cDC1 vaccine facilitates curative immunotherapy in PDAC.
👉 https://t.co/LqUcdUx1SG
RESEARCH | R Nakai, T Yokota, J Brestoff et al. (Osaka Univ, JPN; @washu_pathology)
Administration of exogenous #mitochondria 💉or mitochondrial transfer from wild-type mice improves morbidity and mortality in a mouse model of #Leighsyndrome🐁
https://t.co/leWzOeET9U
Exciting to see this publication come out of the @PanCAN Therapeutic Accelerator Collaborative Awards - exactly what we set out to do. https://t.co/2cqJmpD2un
Congratulations Dr. Liu @SitemanCenter and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM . And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology.
Congratulations Dr. Liu and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM. And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology
A new generation of cancer-preventing vaccines could wipe out tumors before they form.
Learn more: https://t.co/pilczKPfCG @NewsfromScience#ScienceMagArchives
@NCIsysbio A6: A study by @ItaiYanai & team shows tumor cells adapt to anticancer drug treatments by a series of cellular state transitions, each inducing distinct gene expression programs. They utilized scRNA-seq, ST, systematic genetic perturbations, ML techniques
https://t.co/hp1BnFi52a
[1/2] IFNγ produced by γδ T cells stimulates ⬆️pancreatic β cells glucose-induced insulin release that ⬇️hepatic glucose output that ⬆️IFN-I levels by curtailing lactate inhibition of IRF3 & NF-κB signaling to aid responsiveness to viral pathogens
https://t.co/goVGALsrDP
Intriguing paper in this week's Science: a new, much cheaper approach for MRI scanning
It's an MRI scanner that uses a 0.05 Tesla magnet (vs. the current 1.5 - 3 T) and operates at a fraction of the cost (~$22,000 for the hardware), time (<10 minutes), and noise of a current MRI scanner
Unlike current MRIs, the prototype scanner plugs into a standard wall socket, and doesn't need specialist shielding equipment
It uses a deep learning (AI) strategy to improve the low signal-noise ratio that's inherent to lower field strength MRIs
Although the images from the 0.05 T approach aren't as good as from 3 T MRI, they don't seem to be far off
Zhao et al: https://t.co/Fj1C1mWVc5
Cool “bugs as drugs” preprint from @KenOliveLab to start off your Monday. Really great stuff Ken (who is on a roll!)
Tumor-selective treatment of metastatic #PancreaticCancer with an engineered, probiotic living drug
https://t.co/916Lm9HeoC
Photomicrograph showing acylhomoserine lactone activated engineered bacteria localized within primary & metastatic disease sites.