Brett Isis

Husband, father, entrepreneur, former adventurer. Founder of HelloSubs (CEO) & Teaching Nomad.

[Brett Isis @Brettisis]

@chamath Constraint is key

[Brett Isis @Brettisis]

@mikefutia SEO

[GREG ISENBERG @gregisenberg]

I just got back from SF and I FEEL INSPIRED.

I spent 5 days with frontier AI model teams, AI startup founders, and 3 billionaires.

My takeaways:

1. I had lunch with 3 billionaires. All of them are buying SaaS companies and rebuilding them agent-first. They were deeply inspired by Bending Spoons and Ryan Cohen's eBay deal. Buy the company, cut the headcount, rebuild the tech, add agents, add features, make more valuable experience, raise prices.

2. The frontier model companies are hungry for usage data from the field. They can see API calls and token counts. They can't see the actual workflows. If you're deep in a niche using these models in ways the model companies haven't seen, that understanding is incredibly valuable. Usage intelligence is the new alpha.

3. Consumer AI is massively underbuilt. Every billboard in SF is either B2B inference infrastructure or vertical agent companies. The entire city is optimized for enterprise. Meanwhile you have companies like Cal AI doing $50M ARR in 18 months as a consumer app. I met with a cool few teams doing consumer AI (@paulscherer / @ekuyda)

4. MCP came up in literally every conversation. The companies exposing their product as MCP endpoints are getting pulled into deals they never pitched for. The ones that aren't are becoming invisible to agents. This is the new SEO. If agents can't find you, you don't exist. Building products for agents is the new zeitgeist in general.

5. Not uncommon for hot seed rounds to be $25-50 million valuations. I saw a Series A at $450 million

6. If I had a dollar every time someone mentioned "forward-deployed engineer" this trip I could have funded a seed round. It's the hottest role in SF right now. The person who sits between the agent and the customer, making sure everything actually works.

7. The mood around open source shifted. A year ago it felt like open source was chasing the frontier models. Now founders are telling me Gemma and DeepSeek are good enough for 80% of what they need at a fraction of the cost. The "which model do you use" conversation is being replaced by "which model for which task." Model loyalty kinda feels dead.

8. Voice agents came up more than I expected. Multiple founders told me voice is the interface for the next billion users. The billion people who will never type a prompt will absolutely talk to one.

9. The Obsidian community in SF is weirdly intense. Multiple founders showed me their vaults unprompted. Like showing someone your home gym. It's a flex now. The quality of your knowledge base (second brain?) is becoming a status symbol among builders.

10. Maybe it was just the people I met but the age of the founders is shifting. I met more founders over 40 this trip than any trip before and more founders under age 21 than ever before. Founders getting older and younger at the same time.

11. I spoke to a lot of fast-growing startups, VCs and frontier models who are hiring content creators right now.

12. The restaurant scene in SF is actually better than it's been in years. Founders are going out more. Alcohol is out, not surprisingly.

13. SF doesn't feel like the only place anymore. We all have access to the same frontier models. We all read the same X feed. A founder in NYC or Lagos is calling the same APIs as a founder in SoMa. So in the past it felt like SF was always lightyears ahead, doesn't feel that way anymore. It's okay not to live in SF and have BIG DREAMS.

14. The coworking spaces in SF are half empty but the coffee shops are packed. People want to be around people. I had a few startup ideas here....

15. Walking around the Mission I noticed something: the street-level businesses, the taquerias, the barbershops, the laundromats, none of them use any AI at all.

16. I heard the phrase "agent debt" for the first time. Like technical debt but for agents. When you hack together an agent workflow fast and never clean it up, the system prompts conflict, the memory gets polluted, the tools overlap. 6 months later the agent is doing weird things and nobody knows why lol.

17. Met a few people who carry two phones now. One for personal. One that's basically an agent terminal running Telegram or iMessage connections to their agent fleet.

It's always amazing to get that dose of inspiration in SF. I FEEL INSPIRED.

But I'm so happy to be back home, locked in and building.

We're 12-18 months into a shift that will take 15 years to play out. The urgency in every conversation was real.

What an incredible time to be building.

[Brett Isis @Brettisis]

@ColinGardiner https://t.co/yI5pofCUOp

Hope everyone's ok!

[Brett Isis @Brettisis]

@ColinGardiner Try swimming

[Brett Isis @Brettisis]

@ColinGardiner New associate?

[Brett Isis @Brettisis]

@JoinCrowdHealth @SantaCarotaBeef 5678 🥩

[Brett Isis @Brettisis]

@JoinCrowdHealth @andyjschoonover The surgeon walked in and cracked up when he saw the shirt lol

[Brett Isis @Brettisis]

I don't always sleep in a hospital but when I do, I dress appropriately. Thank you @JoinCrowdHealth and @andyjschoonover

[Brett Isis @Brettisis]

@JoinCrowdHealth @andyjschoonover I'm getting a lot of looks! Should have brought business cards with my referral code!

[Brett Isis @Brettisis]

@Jason I'm in

[@jason @Jason]

Here’s the truth: we’ve already reached AGI — we just haven’t implemented it broadly.

Millions of jobs are being lost as we speak.

Entire careers will be retired.

The rich and powerful investors and founders who implement AGI will get bizarrely rich beyond what makes sense. It will break people's brains on both sides.

It’s gonna suck for a lot of our friends and family, who aren’t obsessed with their careers, because things are moving so fast they won’t have even left the starting gate by the time the awards are handed out.

We’re gonna have to solve for a lot of second- and third-order effects, some of which will suck (job loss) and some of which will be awesome.

AI will create free/cheap energy, free education, cheaper and better food, homes that build themselves and medicine that makes you as healthy as a 30-year-old when you’re 100.

… change is hard, but humans are the most adaptable species nature has ever created.

We can figure it out.

[Brett Isis @Brettisis]

@ColinGardiner Or it means you're not moving fast enough.

[Brett Isis @Brettisis]

@jliemandt I'm a big fan of alpha school however i have found myself recently starting to wonder if too much focus on financial incentives/business building is healthy at this age. Worry if it's just a fast track to adulthood. What are your thoughts on this?

[Brett Isis @Brettisis]

@JoshuaBaer @drewricex @Austen Whatcha building?

[Brett Isis @Brettisis]

@ColinGardiner HelloSubs 🤘

[Brett Isis @Brettisis]

Improved medical care with lower predictable cost - yes, please.

[CrowdHealth @JoinCrowdHealth]

It’s our favorite time of year!
It’s time for the:

Quarterly
Quarter
Cow
Contest

One person who retweets and follows CrowdHealth will be eligible for a quarter cow delivered directly to your home by the famous @jakesteaks1
(US only. You do not need to be a CrowdHealth member).

These are grass fed beauties from womb to tomb.

Winner will be announced on 2/09.
Exit the system and join CrowdHealth.

$200/month max for singles <55
$660/month max for family of 4 https://t.co/EHbjXWis0P

[Brett Isis @Brettisis]

@ColinGardiner Couldn't agree more

[Brett Isis @Brettisis]

@bryan_johnson @hubermanlab what's your take?

[Brett Isis @Brettisis]

@JoshuaBaer @CapitalFactory Station Austin!