BulldozerMantra.eth - acc/acc

Acceleration accelerationist

[vitalik.eth @VitalikButerin]

2026 is the year that we take back lost ground in terms of self-sovereignty and trustlessness.

Some of what this practically means:

Full nodes: thanks to ZK-EVM and BAL, it will once again become easier to locally run a node and verify the Ethereum chain on your own computer.

Helios: actually verify the data you're receiving from RPCs instead of blindly trusting it.

ORAM, PIR: ask for data from RPCs without revealing which data you're asking, so you can access dapps without your access patterns being sold off to dozens of third parties all around the world.

Social recovery wallets and timelocks: wallets that don't make you lose all your money if you misplace your seedphrase, or if an online or offline attacker extracts your seedphrase, and *also* don't make all your money backdoored by Google.

Privacy UX: make private payments from your wallet, with the same user experience as making public payments.

Privacy censorship resistance: private payments with the ERC-4337 mempool, and soon native AA + FOCIL, without relying on the public broadcaster ecosystem.

Application UIs: use more dapps from an onchain UI with IPFS, without relying on trusted servers that would lock you our of practical recovery of your assets if they went offline, and would give you a hijacked UI that steals your funds if they get hacked for even a millisecond.

In many of these areas, over the last ten years we have seen serious backsliding in Ethereum. Nodes went from easy to run to hard to run. Dapps went from static pages to complicated behemoths that leak all your data to a dozen servers. Wallets went from routing everything through the RPC, which could be any node of your choice including on your own computer, to leaking your data to a dozen servers of their choice. Block building became more centralized, putting Ethereum transaction inclusion guarantees under the whims of a very small number of builders.

In 2026, no longer. Every compromise of values that Ethereum has made up to this point - every moment where you might have been thinking, is it really worth diluting ourselves so much in the name of mainstream adoption - we are making that compromise no longer.

It will be a long road. We will not get everything we want in the next Kohaku release, or the next hard fork, or the hard fork after that. But it will make Ethereum into an ecosystem that deserves not only its current place in the universe, but a much greater one.

In the world computer, there is no centralized overlord.
There is no single point of failure.
There is only love.
Milady.

[Bryan Johnson @bryan_johnson]

I think magic mushrooms are a longevity therapy.

After seeing the data from two doses, psilocybin offers unique longevity effects that complement the best performing therapies I’ve done to date including sauna, hyperbaric oxygen therapy, sleep, nutrition and exercise.

This was the most quantified psychedelic experiment ever done.

It's noteworthy that even though many of my biomarkers are already in the 99th percentile optimal, psilocybin still showed multi-system improvements. Something other therapies have not been able to accomplish.

Of course, my data will need to be replicated and the magnitude and duration of benefits needs further assessment.

Here is what we learned:

0. We observed broad benefits across mental, hormonal, metabolic, and anti-inflammatory systems. Since these are the primary drivers of biological aging, this multi-system signal offers a compelling case for longevity potential.

1. Psilocybin may be a metabolic reset button for the brain. We expected brain changes, but not a potential metabolic breakthrough. My blood sugar control improved from the top 2% of the population to 0.2%, better than 99.75% of 18-25 year olds.

2. Psilocybin reduced my inflammation (hsCRP) to below detectable levels one week post dose.

3. Psilocybin calmed my body and mind.  Lower cortisol, and an inhibited HPA-axis in the days following the dose. Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery.

4. Psilocybin increased brain plasticity, desynchronized default networks, resulting in enhanced creativity, playfulness, and openness, with reduced mental rigidity.

5. A second psilocybin dose built on the first and pushed sensory integration even further, increasing primary sensory-motor integration beyond the peak of the first dose.

6. Psilocybin induced an intense blend of joy, deep insight, and a subtle hint of melancholy,  also detectable by thermal biometrics.

We had two significant firsts in this experiment:

0. First documented human CGM-based observation of improved post-psilocybin glucose control.

1. First-ever thermal profile of an intense psilocybin dose.

Pending data:
+ Telomere length and relative telomerase activity (telomere regeneration capacity).

+ Epigenetic measurements

+ Microbiome

Experiment details

Here are more details about my two magic mushrooms trips, doses, and the results of my measurements up to date.

I had two doses of dried and powdered Psilocybe Cubensis (Variety  B+) mushrooms, three weeks apart.

First dose Nov 9th: 4.67g (24.98 mg psilocybin and 3.5 mg psilocin). Setting: relatively private, only with @_katetolo and the accompanying guide.

Second dose Nov 30th: 5.35 g (28 mg psilocybin and 4 mg psilocin). Setting: relatively open, with friends and family joining virtually, and live streaming.

I dissolved the first dose in orange juice but used lemon juice for the second, for the following reasons:

+ Lemon is more sour, which delays the conversion to psilocin and breakdown in solution, thus preserving more total psilocybin to be activated to psilocin after ingestion.

+ Lemon juice has, on average, 70% less sugar and 45% less calories, making it less disruptive to my otherwise faster state throughout the journey, and leading to a much lower glucose peak.

Rewired brain connectivity

Kernel Flow measurements after the first dose showed shifts in my brain connectivity mirroring my subjective experience, and the mapping of 5-HT2A receptors.

These included the inhibition of my default networks and command centers including prefrontal context and a shift towards increased functional connectivity and hyperintegration between primary motor, sensory, auditory, and speech integration. This coincided with an entropic brain pattern, more open, flexible, exploratory, and creative, indicating a shift from aged and rigid to open youthful brain state.

The baseline measurement before the 2nd dose indicated a strong lasting effect from the first dose 3 weeks earlier, post-peak measurement after the 2nd dose indicated an additive effect of the 2nd dose, with a brain entropic and increased primary sensory-motor integration beyond the peak of the first dose. Most notable was the increased intensity of integration and activation of the auditory, speech, and language networks, coinciding with the second dose being joined by family, friends, where I enjoyed expressing and describing my feelings.

Face and body thermal biometrics

We produced the first ever face and upper body thermal map of a magic mushroom journey.

A core temperature increase of 1.5–2°F suggests an intense psychedelic experience, likely due to a large psilocybin dose (28 mg psilocybin, 32 mg combined psychoactive content).

Heat was redistributed to the core, consistent with 5HT2A–mediated autonomic activation, which can include increased sympathetic tone, lasting through the peak and early post-peak of the experience.

Facial and body thermal shifts indicate a potential blend of intense joy, insight, and subtle sadness or melancholy.

First documented human CGM-based observation of improved post-psilocybin glucose control

Psilocybin appears to have triggered a previously unknown metabolic reset in my brain, an unexpected breakthrough.  Comparing the 3-day periods before and after the psilocybin dose:

My blood glucose control dramatically improved, moving from the top 2% to the top 0.2% of the entire population, including healthy 18-25 year olds.

+ 8% reduction in mean blood glucose, reaching 80.84 mg/dL, a new personal best.

+ 11% reduction in fluctuation, indicating smoother glucose peaks and improved control.

+ This single session reduced my estimated HbA1c 0.3 6.8% from 4.7% to 4.4%, (a relative reduction of 6.8%).

+ Durability: The positive effect was still as strong on Day 3 post-dose as it was on Day 1.

Note: A long trip to China on Day 4 interrupted this streak. We plan to explore the full durability of this effect with the next dose.

This matters because we treat diabetes and metabolic dysfunction with chronic daily medication (Metformin, Insulin, GLP-1s). This data suggests that a neuroplastic event might have downstream effects on the liver and pancreas that mimic or exceed these drugs.

Systemic inflammation was below detectable levels

Five days after the first dose, my hsCRP dropped to an undetectable level (below 0.15 mg/dL), representing a 35-100% decrease from the pre-dose level of 0.23 mg/dL.

Three days post-second dose, hsCRP was barely detectable at 0.18 mg/dL, which is still a 22% drop from the initial baseline.

Tumor necrosis factor-alpha (TNF-alpha) remained unchanged between baseline and post-second dose. It was not measured after the first dose.

For the next dose, we will measure a wider panel of inflammatory markers, including IL-6 and IL-10, and cover several time points post-dose.

High cortisol at Peak, low cortisol and stress the following week

Cortisol spiked at the peak of the acute phase, followed by a decline in morning cortisol levels and HPA-axis inhibition, consistent with a relaxed "after-glow" phase in the week following the trip.

My cortisol spiked to 3x morning spike levels four hours after taking the mushroom dose. Levels returned to normal nightly baseline before bedtime.

Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.

Estradiol levels increased by 200%, consistent with preliminary published evidence that peripheral 5HT2A activation increases cortisol by driving aromatase expression.

[Emerald Robinson ✝️ @EmeraldRobinson]

1. A few weeks before the 2024 election,@SenMullin and former Senator David Perdue finally arranged a meeting between Trump advisor Susie Wiles and the one man who could explain exactly how America’s election systems are rigged.

The meeting took place at Mar-a-Lago.

[Elon Musk @elonmusk]

Logo complete

[Elon Musk @elonmusk]

@_rockt @GoogleDeepMind We will have real-time in 2 months

[Thomas Massie for Congress @MassieforKY]

I’m one of a very few Congressmen who receive ZERO money from AIPAC.

In fact, they ran hundreds of thousands of dollars of ads against me.

And now their donors are spending millions to smear my name.

Can you help out a true America First congressman?
https://t.co/AgJY01IWPL

[Tim Ferriss @tferriss]

"Learning is not memorizing information. Learning is changing your behavior. If you didn't change your behavior, this is just all mental gymnastics for you. You're just wasting your time." — @FoundersPodcast

[Autism Capital 🧩 @AutismCapital]

🚨ELON MUSK: "I haven't been to DC since May. The government is basically unfixable. I applaud David (Sacks') noble efforts...but at the end of the day if you look at our national debt...if AI and robots don't solve our national debt, we're toast."

[BulldozerMantra.eth - acc/acc @BulldozerMantra]

@josettecaruso @GeneralMCNews Once a state exceeds 100,000 population it should be required to split in half or it would lose representation

[Dinari @DinariGlobal]

🚨 Big news from Dinari 🚨

We just raised a $12.7M Series A to bring U.S. equities onchain — and make them accessible to anyone, anywhere 🧵

[BulldozerMantra.eth - acc/acc @BulldozerMantra]

@GeneralMCNews Is the gold radioactive?

[Bret Weinstein @BretWeinstein]

When I started The DarkHorse Podcast I planned interview remarkable people who had come by their skills in surprising ways—true dark horses. Martin Mullen was the perfect example of the phenomenon, hence our use of The Marble Machine Song as the theme. Thanks to @wintergatan for letting us use it.

If you haven’t seen the original marble machine video, check it out below. And give them a follow so you can enjoy more of their fantastic music and watch Martin construct the next generation of this amazing new musical instrument. It’s a beautiful tour through a gorgeous mind.

And one last thing: please consider circulating this tweet so more people become aware of this hidden gem. Martin and the band do not get the credit they deserve. I’d like to change that as a small measure of my gratitude.

@thedarkhorsepod

[Vivek Ramaswamy @VivekGRamaswamy]

Here’s an open secret on Wall Street: the reason investors pay attention to the Fed isn’t because the Fed has unique insight, it’s mostly just to understand how the Fed is going to screw it up next. There’s ~24k employees at the Fed & that’s easily 20k too many. Go back to a single mandate of stabilizing the U.S. dollar, period.

[KneeOverToesGuy @kneeovertoesguy]

1. Hang

2. Hold

3. Lower

4. Full Reps

I will use this once every two weeks from age 6 to 14 and I will VALIDATE whatever level each student works at.

[RYAN SΞAN ADAMS @RyanSAdams]

Will Quantum kill Bitcoin?

just recorded a podcast with quantum computing legend scott aaronson and cryptographer @drakefjustin

7 takeaways:

1) quantum computers that break current bitcoin & ethereum cryptography are simply a matter of when not if - it's now just a matter of engineering and scale

2) if quantum computers with millions of qubits happened overnight bitcoin & ethereum would be wrecked - attackers could steal trillions in assets and generally god mode both chains - fortunately we still have years until this is possible

3) but when that day comes bitcoin is in for a rough ride - not on the tech layer but on the social - "the community" will have to make a call on bitcoin property rights - no clear path to dealing with the 1 to 4m btc that can be stolen by the quantum attacks (5-20% of all bitcoin lost/inactive cannot be upgraded) - does bitcoin let this happen or breach its immutable property rights - which is least bad for number go up? do we fork?

4) after this there's still the question of PoW - is PoW sustainable in a quantum world or will a new hashing algo be required?

5) ethereum will need to be upgraded too but the path is more clear - likely no property rights impacts and no PoW concerns - achievable, but a large multi-year undertaking

6) not even experts know how soon quantum will happen - likely not in the next 5 years - but if we get a fast takeoff or slow is anybody's guess - it seems likely we'll have time to react as the qubits rachet up...but maybe not much

7) finally it's absolutely wild that there's a multi-trillion dollar worldwide bounty available to the first empire that can build a computer powerful enough to snatch it - enough to incent hundreds of billions of dollars into quantum computing - and yet this trillion dollar treasure could all evaporate into nothing if the social consensus of core devs and full node running bitcoiners so choose

how the heck do we price all this in??

what a weird timeline

episode monday

[Bryan Johnson @bryan_johnson]

Sincerity is not the love language of X. That said….

You motherfuckers need to get your shit together in 2025. You need to stop being stupid and prioritize sleep. You need to move your lazy ass and exercise daily. You need to overcome your fast food addiction and eat healthy.

Your mental health problems stem from the lack of basic self care. Show yourself some respect and stop doing stupid shit that makes you age faster and feel miserable.

We have a very serious situation on our hands as a species. It is not clear that we will survive the coming years and decades. Many things threaten our existence and we’re fucking around with shit that doesn’t matter.

We are primitive and shortsighted. We need to grow the fuck up and be equal to this moment.

Start by getting your own mind and body in order. Lift weights and get jacked. Sleep well and stabilize your mood. Eat well and feel energized.

We have work to do.

Happy Holidays 🎄

[Elon Musk @elonmusk]

Please call your elected representatives right now to stop this madness!

[BulldozerMantra.eth - acc/acc @BulldozerMantra]

@Bubblebathgirl @VivekGRamaswamy This has to be an AI video. Nobody's that stupid

[Marc Andreessen 🇺🇸 @pmarca]

It's interesting to see who is standing up in favor of unlimited, unaccountable, un-appeal-able, unconstitutional power wielded by unelected bureaucrats and rogue politicians.

[Statistic Mania @statisticmania]

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