Excited our ratiometric transcriptional activation (RTA) work led by @Melissa_Gray234 is out online today @CellCellPress! Measurements determine what we can discover in biology; we use RTA to turn protein abundance changes into amplified signals.
https://t.co/3rRhr2pjhu
Excited to share our latest preprint on work led by postdoc Robert Lusi (@noScandineHere)! Introducing ALTER (AGO-Led Targeted Editing of RNA) for non-downregulatory RNA manipulation by repurposing hAGO2, non-immunogenic and capitalizing on evolution. https://t.co/wJa7XIiqwX
Honored to receive the Women in TPD & Induced Proximity Initiative Scholarship to attend the upcoming Keystone Proximity-Based Therapeutics conference! Grateful for initiatives that support and amplify women in science 🙌 Excited to connect and learn!
Excited our final version of @tineisadora's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. @Stanford_ChEMH@StanfordUChem https://t.co/XQFwRmnfaX
Excited to share this work from @tineisadora! Precise control over protein subcellular localization could have massive implications for gain-of-function therapeutic strategies. We showcase targeted relocalization activating molecules (TRAMs) for rewiring interactomes. (1/n)
So proud to share my lab’s first PROTAC in @ChemBioChem#ChemBioTalents! In work led by @ErikoKoide & Kaela Mohardt, we developed a selective in vivo-compatible FAK inhibitor and PROTAC with exciting activity in pancreatic cancer models. A few highlights:
https://t.co/SKAgkHKJG0
So exciting to see my graduate work published! Thank you to everyone who made this paper possible! @cthoyt @benjamingyori @HiTSatHarvard @DFCI_ChemBio
Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes https://t.co/9wyswADgCL
A new paper from Jack Taunton and colleagues developed salicylaldehyde-based chemical probes that reversibly and covalently modify the catalytic lysine of protein kinases, with sustained occupancy in cells and animals. Free to read: https://t.co/yDviFO3J3v https://t.co/4deMHTFmwv
Milestone day for our team!! Check out our lab's first paper @fredhutch disclosing our CDK11 inhibitor! In work led by @ZhengnianLi and Ryosuke Ishida, we developed a new chemical probe (ZNL-05-044) for studying this fascinating understudied CDK. https://t.co/vDqTEEjkVR
The Nabet lab @fredhutch is hiring! We are seeking a curious and highly motivated Research Technician to join our growing team and have exciting projects aimed at advancing new targeted protein degradation technologies. Please RT and apply here:
https://t.co/VQv28sv8LT