Mingde Cao

Student t/Sports Medicine/Arthroscopy/phd student

[Mingde Cao @CaoMingde]

Excited to be part of an Health longevity project, looking forward to developing novel therapeutic to tackle OA pain

https://t.co/hQcb4IfdIe

[Alibaba Cloud @alibaba_cloud]

Meet Qwen3.6-27B, our latest dense, open-source model, packing flagship-level coding power!

What's new:
Outstanding agentic coding
Strong reasoning across text & multimodal tasks
Supports thinking & non-thinking modes
Apache 2.0

Smaller model. Bigger results.

[Waggoner Lab @LabWaggoner]

Biological sex shapes divergent cellular and transcriptional trajectories of human immune aging, with stronger cellular and molecular remodeling in female than male participants @NatureAging @marta_mele_m 🇪🇸
https://t.co/pRDsNZbSH7
https://t.co/8s6koqZyka

[Science Magazine @ScienceMagazine]

In a new Science study, researchers report that specific regions dense in cytosine and guanosine dinucleotides are epigenetically modified during inflammation to enable gene expression and that these changes persist during the animal’s lifetime.

The finding has implications for understanding how the genome determines the longevity of memory, which affects tissue fitness.

Learn more in a new #SciencePerspective: https://t.co/VJwEsaHD5W

[Waggoner Lab @LabWaggoner]

Inflammatory arthritis after checkpoint blockade is a T cell–driven, autoantibody-independent autoimmunity
https://t.co/GT2ln3WQUd
@UmaThanaMD @MayoClinic @scienceadv

[Adrian Liston @LabListon]

A one minute primer on how #AutoSpectral improves spectral flow cytometry unmixing by using per-cell calculation of autofluroscence spectra.

Use our R package and get higher quality spectral data, easy as that!

https://t.co/BG3DVIM13r

[Mingde Cao @CaoMingde]

Wrap up the 2026 ORS.
#ors2026

[Osteoarthritis and Cartilage Journals @OACJournal]

🚨Standard scRNA-seq often excludes cells with high mitochondrial RNA content (pMT).🚨

Work by Tran et al. investigates how exclusion of high-pMT cells affects the transcriptional landscape of knee OA synovium and explores their role in disease.

🔗https://t.co/UV0hy7VYOA

[Simplifying AI @simplifyinAI]

🚨 BREAKING: You can now run full drug discovery pipelines inside Claude Code with one command.

Claude-Scientific-Skills is an open-source plugin that gives Claude Code 140 ready-to-use scientific workflows with a single install. It covers biology, chemistry, medicine, and ML without manual configuration.

→ Connects to 28+ databases like PubMed and ChEMBL.
→ Run drug discovery pipelines and molecule docking.
→ Analyze raw single-cell data and map gene networks.
→ Cross-reference clinical variants and drug interactions.

100% Open Source.

[Michael Vinyard @vinyard_m]

I just updated the scDiffEq Python API (v1.1.0) to include animated visualizations of simulations.

You can generate GIFs (or still images) showing:

- Temporal gene expression dynamics
- UMAP projections of simulated trajectories

During my PhD, I found animations like these useful in presentations.

Available now in the latest release: https://t.co/Wkl0My7xT8

[Crémieux @cremieuxrecueil]

The biggest argument against using GLP-1s for weight loss is that they cause excess muscle loss.

But as it turns out... GLP-1s do not cause any more muscle loss than traditional weight loss methods!

Let's discuss🧵

[Waggoner Lab @LabWaggoner]

Estrogen tunes a cross-talk between hormone-secreting cells in the mouse gut to regulate visceral pain
https://t.co/14MaakmoAW
https://t.co/Th1DtbDNYo
@ScienceMagazine @hollyingrahamSF @UCSF
preview by @FlyGutLab

[Mingde Cao @CaoMingde]

@ScholarshipfPhd Hi

[Ming "Tommy" Tang @tangming2005]

1/ How to quantify a transgene (e.g., TdTomato, GFP) in scRNAseq data? You need to add the transgene to the reference. See my post https://t.co/7lnIW6kYMF However, it is not always working 👇

[CUHK Medicine @CUHKMedicine]

The latest edition of the Sports Physician Handbook (Fourth Edition), edited by the International Federation of Sports Medicine (FIMS), and co-edited by Professor Patrick YUNG, Associate Dean (Mainland Affairs); and Chairman of the Department of Orthopaedics and Traumatology of CU Medicine was officially released in Hong Kong.

[Mingde Cao @CaoMingde]

@ScholarshipfPhd 👋 hi

[Oded Rechavi @OdedRechavi]

Having a PhD means you can find the word “unfortunately” in an email faster that the search function

[Mingde Cao @CaoMingde]

Reviewer: why did you not perform pressure-pain hyperalgesia?
We just bought it…😹

[Osteoarthritis and Cartilage Journals @OACJournal]

Are you a creative scientist?🧐
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
https://t.co/edgTpdqX0n

[Nature Metabolism @NatMetabolism]

Tracking dietary exposures with metabolite biomarkers https://t.co/h7onh4s6Q5

[Yale Center for Research on Aging (Y-Age) @YaleAge]

The Nerve-associated macrophages (NAM) decline w/age & their removal increases inflammation & metabolic dysfunction. Study also discovered a new population of macrophages called Age-associated Macrophages (AAMs) that appear in old animals & display pro-inflammatory features.