Carlos Costas Insua

Post-doc @CBM_CSIC_UAM. Previously Post-doc @ZMBhH & PhD @BBM_UCM. Molecular Neuroscience 💡🔬

[Eduardo_Balsa @BalsaEduard]

📢 PhD position available in my lab at CBM-CSIC/UAM (Madrid)!

We’re looking for a motivated candidate to study how metabolism shapes metastatic organotropism and uncover organ-specific metabolic vulnerabilities.

📩 [email protected]
📅 Deadline: 30 Oct 2026
Please RT!

[Carlos Costas Insua @Carlos_Costas]

📤Excited to share our new paper in @PNASNews! 🎉

How does cannabinoid tolerance develop with repeated exposure?

We found that sustained CB1R activation triggers a pathway leading to its own degradation:

CB1R → PLC–PKC → NEDD4L → ubiquitination → proteasomal degradation

[Sonia Castillo Lluva @Sonia10180062]

My latest research on Breast cancer metastasis has just been published with @springerNature in Signal Transduction and Targeted Therapy. Read more: https://t.co/744HSx3dwZ

[Carlos Costas Insua @Carlos_Costas]

Shoutout to our magnificent collaborators @MarsicanoLab & @mrt_isasa, and to @AgEInves @CIBER_ISCIII for the funding! 🙌

[Carlos Costas Insua @Carlos_Costas]

📤Excited to share our new paper in @PNASNews! 🎉

How does cannabinoid tolerance develop with repeated exposure?

We found that sustained CB1R activation triggers a pathway leading to its own degradation:

CB1R → PLC–PKC → NEDD4L → ubiquitination → proteasomal degradation

[Carlos Costas Insua @Carlos_Costas]

Big congratulations to Alicia, our fantastic first author, who led this work and uncovered how NEDD4L-driven CB1R ubiquitination contributes to cannabinoid tolerance. So proud of what she and the team accomplished! 🎉

📄 Read the paper: https://t.co/hY9afuSrgD

@PNASNews

[Busquets-Garcia Lab @BGarcialab]

🔔New from our lab! With @bolanosjuanp and @MarsicanoLab, we show that adolescent THC induces a transient, sex-specific mitochondrial mechanism in astrocytes that drives lasting behavioral effects. Supported by @CaixaResearch. Congrats to all co-authors!

https://t.co/aQiJBBinLp

[Jose Lucas Lab @JJLucasLab]

Back from Boston HD2026 Milton Wexler Meeting. Thanks @hdfcures for organizing it. Excellent science and discussion to advance in the understanding and cure of HD. Very grateful for the opportunity to present our latest work, including promising news from #HUNTIAM clinical trial

[Ralph Grand @RalphSGrand]

Excited to share our first story led by @MartinaCapriat! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

[Martina Capriati @MartinaCapriat]

Exciting news 📣 The first preprint from Grand lab (@RalphSGrand ) is out 🧬

How are essential genes controlled?

By rapid degradation and recovery of TFs alone or in combination, we show that essential genes rely on a single dominant TF, despite dense co-binding.

[Jose Lucas Lab @JJLucasLab]

Muy orgullosos de Julia @jposeutrilla por su premio al mejor póster #CIBERNED durante el congreso #NeuroRare, sobre el defecto del transportador cerebral de tiamina en Huntington y los avances del ensayo clínico HUNTIAM👏👏👏
@CIBER_ISCIII @CBM_CSIC_UAM @ehuntingtones @SENC_

[Jose Lucas Lab @JJLucasLab]

Gracias a todos los miembros del CBM y de nuestro laboratorio por implicarse en esta puesta en común con las familias
@Julia15351381 @Carlos_Costas

[Carlos Costas Insua @Carlos_Costas]

I’m beyond thrilled to share that my MSCA Postdoctoral Fellowship has been selected for funding! 🎉
Super excited for the science ahead at @JJLucasLab @CBM_CSIC_UAM @CSIC. Stay tuned! 🧑‍🔬

[Nature Neuroscience @NatureNeuro]

Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice

https://t.co/j8GJXVrkDT

[Carlos Costas Insua @Carlos_Costas]

@bertalsl @JPLopezAtalaya @GemaMorBue @NietoAngela This is amazing! Congrats @bertalsl @SciJav

[Gertru Perea @GertruPereaLab]

WE ARE HIRING!!
Looking for a PhD project? Neuroscience lovers, this is your place! Apply now!!! Deadline is 28/12/2024 👌
@InstitutoCajal @SENC_ @CSIC @CSICdivulga @FENSorg
@PilarQuijada3
@DNeuro_UPO @ucc_complutense
@master_uc3m @UAM_Madrid @UABBarcelona

[SfN Journals @SfNJournals]

#JNeurosci: @MarotoIrene @Carlos_Costas @MarsicanoLab et al. reveal an important role of GAP43 in corticostriatal function and provide a new mouse model with a delimited neuronal-circuit alteration for basic and translational researchers in the mental-health field. @BBM_UCM @unicomplutense
https://t.co/ib4BSfYGhk

[Jose Lucas Lab @JJLucasLab]

Finally out https://t.co/NwSmunseCb the study (led by @xsalvatella1 & @RMendezLab) with the biophysical explanation for the profound effect of the microexon of CPEB4 as cause of autism, that we previously reported back in 2018
@ParrasAlbert @GeschwindLab @mirimiam @hervas_millan

[Juan José Millás @JuanJoseMillas]

El Estado llegó tarde porque la sobremesa se alargó.