Catherine Freudenreich

Professor of Biology at Tufts University. My lab uses yeast genetics to study how cells protect their genome from breaks and repeat instability

[Catherine Freudenreich @CatherineFreud2]

A very cool paper about how the human Shu complex regulates recombination with potential implications for cancer therapy. Congrats to first author Sarah Hengel and all coauthors for this important scientific advance!

[Tufts Biology Department @Tufts_Biology]

Tufts Bio’s Mitch McVey and his merry band of scientists made some new data — check it out!

[Tufts Biology Department @Tufts_Biology]

🚨🚨🚨We’re excited to give a Jumbo welcome to @tran_khoa, who’s joining Tufts Bio as an Asst Prof in Sept’25! Learn about Khoa and his research on metabolic-epigenetic crosstalk here: https://t.co/OgGn3q2MrM

[Catherine Freudenreich @CatherineFreud2]

Got this very cute present from former postdoctoral fellow Erica Polleys @EricaJeanPhD who contributed so much to my lab’s research. Made by a former grad student in our department who sells great science stuff on Etsy

[Catherine Freudenreich @CatherineFreud2]

@mcveylab I second. So happy to have you join our department!

[Vincent Dion @VDion_and_Lab]

Our new manuscript is online!
Cas9 nickase-mediated contraction of CAG/CTG repeats at multiple disease loci
https://t.co/SWi5SHyH9c

Giant team effort! Led by the incredible @Alvaro_MurilloB with more help from @mariahlelos, @lab_davidson, and many many more.

Here's a thread.

[Catherine Freudenreich @CatherineFreud2]

I had the pleasure of watching this story develop. An important contribution to the repeat field!

[Julia Hisey @julia_hi_c]

Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures https://t.co/I4Q1b1UUUc

Super proud of this work from my PhD! Thanks to amazing scientists @semirkin @GabrielMatosRo5 @nussenza @chiara_masnovo @AHzRs and more!

[Daniele Fachinetti @FachinettiLab]

#1 Happy to share our work “Specialized replication mechanisms maintain genome stability at human centromeres” @MolecularCell from A. Scelfo, A. Angrisani and T. Wilhelm @institut_curie @CNRS where we provide the causes of centromere fragility.
https://t.co/2nxkj1mFGm

[Anna Clemens, PhD @scientistswrite]

If you found this thread helpful and would like to know how to develop your paper so that it is well structured and tells a consistent story, here is a free training for you:
👩‍💻👇

https://t.co/gVy3cWob0G

[Catherine Freudenreich @CatherineFreud2]

You are a real Jumbo now Sarah. Playing softball with @Tufts_Biology and the librarians!

[David R. Liu @davidrliu]

Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemically competent MachOne (or other E. coli) cells, and Gibson assembly mix. Postdoc Julian Willis—who is starting his own lab in the UK soon—developed homemade recipes for each that reduce costs ~3x (or more at large-scale). Links to each recipe:

RCA mix:
https://t.co/Cmir57uM0J

Chemically competent MachOne cells:
https://t.co/kNYVxLIToA

Gibson assembly mix:
https://t.co/OFwXmmLDWB

[Catherine Freudenreich @CatherineFreud2]

A nice read! Thanks for writing such a clear summary on the danger of DNA structures exposed within gaps.

[Sharon B. Cantor @CantorLab]

Not sure why gaps are bad, have a read. https://t.co/jtfho8X4tt

[Catherine Freudenreich @CatherineFreud2]

Great to see 4 awesome women scientists doing such important service for the community!

[Joann Sweasy @DrJoannSweasy]

Wonderful to join cancer center directors from the Four Corners @NeliMUlrich @UNMCCC and the NCI Director @NCIDirector at the annual Cancer Center Directors meeting at the NCI.

[SGD Project @[email protected] (bsky too) @yeastgenome]

Register now for #yeast2023! Submit abstract by May26, Early bird registration by May31! Get your summer dose of yeast #genetics in Tuscany 🌞 https://t.co/zwbnJnRRuK

[SGD Project @[email protected] (bsky too) @yeastgenome]

Got old #yeast? Zhou et al rewire #transcriptional death pathway switch away from typical #nucleolar or #mitochondrial decline to delay #aging via negative-feedback loop, increasing life span by 82% https://t.co/5l1Xn576CQ @ScienceMagazine Long live yeast!

[Vincent Dion @VDion_and_Lab]

We're looking for a Research Assistant to develop better #AAV constructs for #Crispr Cas9 expression for #GeneEditing in vitro and, eventually, in the brain.

Join a vibrant group of people at the @UKDRI at Cardiff! Closes May 14th! apply here:

https://t.co/l4tN4mFMhk

[Catherine Freudenreich @CatherineFreud2]

Kudos to postdoctoral fellow Erica Polleys for establishing this system to study repeat instability during gap repair. And for her discovery that DNA structures within gaps create a super fragile site!

[Grant Stewart @GS_Lab_Bham]

Great work from the @davidkcortez lab!

https://t.co/JjOX3FWCay

[Maria Spies, PhD (she/her) @maria_spies]

Hot of the press in NAR Cancer. Culmination of many years of effort, Divya's PhD, the project started by @science_SRH while in my lab, and a wonderful collaboration with Ashley Spies' and @PietroPichierri
labs
Check out our new, drug-like RAD52 inhibitors
https://t.co/5DENYj130F

[Catherine Freudenreich @CatherineFreud2]

@maria_spies @science_SRH @PietroPichierri A really novel study with important implications for cancer treatment avenues. Congrats all!