Chloé Savignac

PhD student @IPNMcGill & @Mila_Quebec | MSc in CompNeuro | Exploring the world of ML and its application to single-cell genomics | FRQS & CIHR fellow

[Chloé Savignac @ChloeSavignac]

We contrasted the effects of APOE ɛ2 and ɛ4 in the largest existing epidemiological cohort @uk_biobank. Our findings link sex-specific modifiable risk factors to the protectiveness conferred by ɛ2, namely lacking physical activity in females and chronic social isolation in males.

[PLOS Biology @PLOSBiology]

Effects of APOE alleles ɛ2 & ɛ4 in @uk_biobank participants shows that the protective effect of #APOE ɛ2 on #AlzheimersDisease risk is sex-specific & linked to distinct #hippocampus-#DefaultNetwork co-variations @ChloeSavignac @danilobzdok &co #PLOSBiology https://t.co/YHF4bSUcSx

[Yale Department of Genetics @YaleGenetics]

A new human cortical culture system tracks cell fate during neurogenesis. Single-cell CRISPRi screens of 44 transcription factors reveal new TFs that regulate self-renewal, differentiation, and lineage progression.
https://t.co/YYzNU0jrDi

[Gary Marcus @GaryMarcus]

Feel the AGI, @sama.

No PhD student can match this!

[Nature Human Behaviour @NatureHumBehav]

Using multi-modal data from the UK Biobank, @lezhou1 @danilobzdok et al. delineate the phenotyping and brain basis of early risers and night owls at a population scale, showing links to habit formation and emotional regulation.
https://t.co/GUpb09ZqmP

[Mila - Institut québécois d'IA @Mila_Quebec]

Mila researchers Jack Stanley (@jackhtstanley) and Danilo Bzdok (@danilobzdok) published a paper in the general-domain journal @CellPressNews, one of the most influential scientific journals in the world. Their work uses LLMs to analyse vast quantities of data from written reports by medical professionals in order to better understand — and hopefully improve — how autism diagnosis is performed. Read the article https://t.co/nxtUCTVgd4

[Cell Press @CellPressNews]

Trained language model finds repetitive behaviors and special interests are more indicative of an autism diagnosis than a lack of social skills. https://t.co/0eUoONJiLs

@Mila_Quebec Danilo Bzdo
@CellCellPress

[Prof. Nikolai Slavov @slavov_n]

This rate of validation suggests that antibodies should be considered non-specific until proven otherwise:

357 validated out of 1,124 tested.

.

[Martin Picard @MitoPsychoBio]

Mitochondria are transferred between cells, tissues and organs, particularly in response to stressors

New exciting layer of mitochondrial biology showing the importance of cell-cell interactions and that mitochondria convey information/signal widely

https://t.co/iHWXHVF34o

🧵

[Frontiers - Neuroscience @FrontNeurosci]

New Research: Annao Pingchong decoction attenuates oxidative stress and neuronal apoptosis following intracerebral hemorrhage via RAGE-NOX2/4 axis https://t.co/ro5GGtIWBo #FrontiersIn #Neuroscience

[Nicholas Fabiano, MD @NTFabiano]

The potential role of psilocybin to alter mechanisms associated with dementia.

🧵1/10

[Michael Mindrum, MD @MichaelMindrum]

1/ Ghrelin, the "Hunger Hormone". Hunger isn’t just a feeling—it’s a finely tuned biological response. Ghrelin connects the gut, brain, energy use, storage, and tissue repair. Let me explain: 🍽️ 🧵

[Cell @CellCellPress]

Now online! Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes https://t.co/1b5a8hfPnX

[The Nobel Prize @NobelPrize]

Remembering the first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories: Marie Skłodowska Curie.

Curie was born #OnThisDay in 1867.

[Nature Neuroscience @NatureNeuro]

Multimodal data from 98 individuals: neuroimaging, genetics, dendritic spine morphometry, proteomics, and gene expression; identifies 100s of proteins that explain individual differences in MRI measures

@HerskowitzLab

https://t.co/JW0xxRnhxT

[Marios Georgakis @MariosGeorgakis]

Some good recent review reads on genetics & omics📚

👉adding CNVs to GWAS https://t.co/7bpf2o20Hk
👉using different omics QTLs to detect causal variants/mechanisms https://t.co/pVJbtsO3Yr
👉genome-scale metabolic models https://t.co/p0dnm5bbMG

[Eric Topol @EricTopol]

A biomedical first: spatial biology used to find a lifesaving treatment!
Just published @Nature
Deep visual proteomics with #AI leads to effective JAKI treatment for 7 patients with toxic epidermal necrolysis
https://t.co/lUiEJL0lGI @labs_mann @NordmannThierry

[Prof. Nikolai Slavov @slavov_n]

I am always happy to hear from colleagues who find the initial community recommendations helpful.

https://t.co/8nPybyu9Et

[Danilo Bzdok @danilobzdok]

Anwesha talks about her upcoming #transcriptomics research in #neurodegeneration in this video here:

https://t.co/14NBLqXfNw

[Nicholas Fabiano, MD @NTFabiano]

A single dose of psilocybin changes the brain.

🧵1/12