Christopher Pepin

Bioinformatics @ Orna Therapeutics. Fun with RNA, NGS, bioinformatics, stats, ice cream, and the occasional wildlife photo. Tweets + opinions = my own.

[Raphael Townshend @raphaeljlt]

Excited to see this out! Atomic was built from the ground up to fuse both cutting-edge experimental work and AI, and the ATOM-1 foundation model is a beautiful example of this in action.

Onwards and upwards to unlocking a whole new world of RNA-focused therapies!

#ATOM1 #RNA

[mihir metkar @MihirMetkar]

Delighted to share our new review "Tailor made: the art of therapeutic mRNA design," co-authored with @mooreorless62 and @ChristophPepin. We explore the fascinating interplay between mRNA sequence & structure in mRNA medicine. #mRNA #therapeutics #mRNAdesign

[Immunity @ImmunityCP]

One man's niche is another man's treasure 😀

[Fiona @FionaSmall]

The tweet and replies to the time someone once wore a beret in Waterford is an instant classic

[Jake Elder @Jake_Elder52]

This post’s first comment is one of the best and most thorough distinctions between R and Python I’ve read
https://t.co/GPtD4RdQfM

[Anton Petrov @AntonIPetrov]

Say hello to RNAcanvas and XRNA-React! 🌟

Now you can visualise RNA secondary structures in #R2DT and edit them to create publication quality diagrams, all in your browser 🎨✨

https://t.co/xkONr3SN7e

[Tony Mustoe @TonyMustoe]

Really happy this is now out! Awesome work from David Mitchell, Jenn Cotter, and @saleem_irfana showing that DMS can be used to probe all 4 bases in cells. Please give it a try!
https://t.co/pOwRiKwrva

[Joseph Watson @_JosephWatson]

DALL-E’s amazing images are popping up all over the web. That software uses something called a diffusion model, which is trained to remove noise from static until a clear picture is formed.

Turns out diffusion models can design proteins too!

[Ed Yong is not here @edyong209]

And this final pandemic piece is a distilled shot of the argument I’ve been brewing for 3 yrs. This has been soul-crushing work. We constantly forfeited the chance to do better. But that chance still exists, and we can’t afford the luxury of nihilism. 6/

https://t.co/KG8EuVcWKS

[vicki @vboykis]

🎉🚨This is real. 🚨🎉
#NormConf is happening.

https://t.co/9roskd3MMD
December 15.
Online.
Free.
A day of normcore data takes.
It’s gonna be great.
Registration is open.

[Yiliang Ding @YiliangDing]

Two preprints on the RNA G-quadruplex functions in response to stress in plants and human!!!
RNA G-quadruplex structure contributes to cold adaptation in plants. Our new preprint from the lab with @kitkwok6. https://t.co/MQBDhCWnGZ

[andrew giessel @giessel]

Happy to announce that our paper on using VAEs for enzyme protein engineering is out in Scientific Reports today! Paper is here: https://t.co/7IZ7B3qUlC Code is here: https://t.co/VyV2r2kQGm.
I'm v grateful for all the help everyone involved at Moderna past and present.

[Christopher Pepin @ChristophPepin]

Hooray hooray hooray!

[andrew giessel @giessel]

I'm happy to announce the open-sourcing of SeqLike, a Python library for modern computational biology workflows. SeqLike is the result of a lot of careful and collaborative API design and has been in production at @moderna_tx for multiple years. https://t.co/SO7oSfgxRn 🧵

[Moderna @moderna_tx]

Our #DataScience and #AI team has released our first open-source software project: SeqLike!🙌
SeqLike is a #Python library that supports multiple computational research and production workflows at Moderna. https://t.co/fJVuTZkf13.

[Dr Ellie Murray, ScD @EpiEllie]

Everyone keeps talking about covid becoming endemic, but as I listen to the conversation, it’s becoming more & more clear to me that very few of you know what “endemic” means.

So here’s a thread on how pandemics end.

[The RNA Society @RNASociety]

Delighted to announce inaugural RNA-themed Baking Competition in celebration of RNA Day (Aug 1st)! Details of how to submit your RNA-themed confections (photos of) in @RNASociety member email inboxes 🎂 🍰 🧁

[The Ribozone Podcast @RiboZonePodcast]

Check out our newest episode talking life and #glycoRNA with Ryan Flynn (@raflynn5)!

https://t.co/bfPSpej1IY

[The Ribozone Podcast @RiboZonePodcast]

Episode #1 - Alexandra East-Seletsky (@alexseletsky)

Find out about her time in the @doudna_lab and her experiences at @ArrakisTx!

https://t.co/GNdYT4QAus

[Bloom Lab @jbloom_lab]

Finally, as scientists, we need to continue to do our best to avoid political / opinion-based arguments about #SARSCoV2 origins / early spread, and remain focused on following two questions: (1) How can we get more data? (2) How can we better analyze the data we have? (15/n)

[Konrad Karczewski @konradjk]

We're thrilled to release a manuscript on rare variant association testing on the exomes of 300k individuals in the UK Biobank https://t.co/Kgyc9Vk7Nq and a browser of the results: https://t.co/c8PJajiHK3