Ciaran Lee

Genome engineer / Science enthusiast / Rare disease

[Ben Kleinstiver @BKleinstiver]

Check out our @biorxivpreprint describing our efforts to treat a severe vascular disease 🫀:
1️⃣ Optimization of a target-specific base editor🧬
2⃣ A *must avoid* bystander edit prevalent with WT SpCas9 BEs! 🙅‍♂️😱
3⃣ Substantial extension of lifespan following in vivo base editing! 🐁✅

A 🧵 below with more details!
@CGM_MGH @MGH_RI @MassGeneralNews @harvardmed
https://t.co/OZlW9ntsQw

[Arash Bagherabadi @arash_b_abadi]

🧵 A Thread on “Julia for Biologists” 🧵

1/ Introduction to Julia

A 2023 perspective in @naturemethods highlights #Julia as a powerful programming language for computational biosciences!

🔗 Full article: https://t.co/YIN4qXgvyT

[Simon Duerr @simonduerr]

This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) https://t.co/qYzIsbr0TH

[Fund Immunotherapy Ireland @FundImmuno]

My name is Bernard, living in Ireland. I have stage 4 stomach cancer. My medical consultants recommend Immunotherapy and chemotherapy. Despite best scientific and clinical evidence, my Irish healthcare insurer won't fund this. Am I alone?

[lexbouter.bsky.social @LexBouter]

"...the term ‘paper mill’ may fail to fully capture the diversity and scale of activities overseen by these hydra-like conglomerates." https://t.co/vF7T6L5xv3
@WCRIFoundation @NRIN_Integrity @MicrobiomDigest @JAByrneSci @fake_journals @peerrevcongress

[Lior Pachter @lpachter]

So this plagiarism thing has happened to our lab.. again. This time it's plagiarism of our poseidon syringe pump paper @booeshaghi et al., 2019 in @SciReports: https://t.co/JLWrOK2Lr4
Text has been plagiarized, as well as figures copied directly here: https://t.co/qzAdvj9H44 1/🧵

[Paul Cotter @pauldcotter]

A lantibiotic producing Bifidobacterium!! 🤩🤩🤩
Fantastic work from @Rociio_sg with @PaulaOC95236752 @ianjoneill @phagebrain @CiaranMLee @McEvoyRebecca @ProfFMcAuliffe @VanSinderenLab

https://t.co/MQSz4BRR2E

[Lior Pachter @lpachter]

In a recent preprint https://t.co/dKzVFb9z2y we discussed major differences in results one obtains with different versions of Cell Ranger due to changes in the way reads are counted. Now another preprint corroborates the finding that results are very dependent on CR version.

[Waggoner Lab @LabWaggoner]

Paradigm challenged: gene expression is driven by DNA sequence variants with little contribution by methylation
https://t.co/bTbqIr6vPi…
@NatureGenet @decodegenetics @nanopore https://t.co/bMmJy4uZBi

[Lior Pachter @lpachter]

The mantra that spatial transcriptomics is about location, location, location is catchy, but what does it really mean? We have just posted https://t.co/oE9X6dHIko, work of Kayla Jackson et al., that describes the concordex method for identifying spatial homogeneous regions. 1/🧵

[Elisabeth Bik @MicrobiomDigest]

Academic journals are a lucrative scam – and we’re determined to change that

@AAbizadeh writes @guardian

https://t.co/8REXFMUTnE

[Nature Biotechnology @NatureBiotech]

Breathing new life into in vivo lung editing https://t.co/JqGT70UftG

[Linda Doyle @LindaDoyle]

The most recent @EU_Commission Country Report on Ireland lists ‘Low levels of investment in research and development that hold back innovation, productivity and growth, especially in the domestic industry’ as a competitiveness threat.

Read it here -
https://t.co/HoIrKKm1WR

[Lisa Keating @DrLisaKeating]

Getting to the heart of the matter @malcolmbyrne pressing @DeptofFHed @podonovan to honour the Gov commitment to fund the shortfall identified in Higher Ed funding. Two years on and the €307m gap is growing instead of reducing @IUAofficial @JimMiley @IRLDeptPER @SimonHarrisTD

[Lisa Keating @DrLisaKeating]

“A transformative funding programme-the Chuck Feeney-inspired Programme for Research in Third Level Institutions (PRTLI) which fostered world-class research &reversed a brain drain of top talent–was discontinued”⁦@PresHughBrady⁩ ⁦@IUAofficial⁩

https://t.co/OVD6zoHDwL

[Adrian Liston @LabListon]

Biggest paper yet from the lab out now in @ImmunityCP! It is a massive #openscience resource on #tissueTregs, and what makes #Tregs tick in the #tissues. Spoiler-alert: Tissue Tregs are really different from what we all thought. 🧵 1/21

https://t.co/k8q7LhMewB

[The Soh Lab @ Stanford @HTSohLab]

We are excited to share our latest preprint on a new solution to next-generation peptide/protein sequencing.

Peptide sequencing via reverse translation of peptides into DNA https://t.co/IFtp2hGZ4I

[Dimitrios L. Wagner @dlwagner13]

Wanna move CRISPR genome editing to the clinics? Wanna to build tech to tackle the big challenges of cell therapy? 🧬✂️🩸

Join us as a Postdoc at @CAGTHouston @bcmhouston - Please RT 🙏

https://t.co/CxVUp1Q1dY

[Cost Action GenE-Humdi @GeneHumdi]

⚠ ONLY ONE WEEK FOR MARC GÜELL WEBINAR!! ⚠

It will be the opening of the GeneHumdi Young Researcher Webinar Series 🎉
😍 Are you not excited??
and more important:
⁉ Did you already sign up??!!
if you didn´t: DO IT NOW❗
It is free , do it here:
https://t.co/4Ed0fKiNmo

[Nature Medicine @NatureMedicine]

The search for authentic microbiome–disease relationships.
A new study challenges the validity of previously reported microbial markers and serves as a wake-up call for the #microbiome research field. News and Views from @zhu_ruixin & colleagues
https://t.co/IPSwgbud9n