Joe Walton

If you wish to make an apple pie from scratch, you must first invent the universe. - Carl

[Joe Walton @Cool_Genes]

"PBRM1, SETD2 and BAP1 -- The trinity of 3p in clear cell renal cell carcinoma"
https://t.co/WedEE9Wkwp

[Joe Walton @Cool_Genes]

Excited to share our new commentary in Kidney International! We explore RASSF1A loss in ccRCC, genomic instability, and the critical role of chromosome 3p. Read it here: https://t.co/N72MmyuQvP

[Thomas Kislinger @KislingerThomas]

Last paper for 2024. Nice work by @mrwaas on proteomics of HNSCC tissues to identify novel biomarkers within the N0 population. Great collaboration with @laillesuhnrese1 and support from many colleagues @PMResearch_UHN

[UHN Research @UHN_Research]

🧬 Breakthrough in #KidneyCancer research! Scientists @PMResearch_UHN have found a new treatment target for clear cell renal cell #carcinoma—PRMT1.

Read about this target's role in regulating DNA & how this opens the door for future therapies ➡️ https://t.co/1hHoHyor2I

[Joe Walton @Cool_Genes]

Congratulations @sandyserena___ !! 🤩 Amazing work!! 🥳

[Sandy Serena @sandyserena___]

Incredibly excited to share my PhD work published in @ScienceAdvances today.

For the first time, we have identified 1) a biological role of ADO AND 2) unexpected mechanism of essentiality that is unique to cancer cells.

https://t.co/modZpntoHS

(1/n)

@UofTIMS @PMResearch_UHN

[UHN Research @UHN_Research]

New hope for kidney cancer patients! 🎗️

Researchers at @PMResearch_UHN discovered that blocking PRMT1, an epigenetic protein, causes kidney #cancer cells to self-destruct.

This breakthrough could lead to new #treatments for the deadliest form of the disease.

Learn more⬇️

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

New therapeutic target for kidney cancer🎯

A team led by @laillesuhnrese1 @UHN found that inhibiting the protein PRMT1 can shrink kidney tumours by disrupting RNA metabolism and creating DNA damage. This discovery paves the way for new treatment options.

https://t.co/B8gBRXTerc

[Joe Walton @Cool_Genes]

@sandyserena___ Aww, thanks Dr. Sandy!!! 🥰

[Joe Walton @Cool_Genes]

🚨 Excited to share our new publication in @NatureComms on PRMT inhibition in kidney cancer! 🙌 Big thanks to @laillesuhnrese1, @thesgconline, @CherylArrowsmi1, @BrianRaught, and the entire team!👏Read more here: https://t.co/MBvnoo5CKM #cancerresearch #kidneycancer #UHN

[Princess Margaret Cancer Centre @pmcancercentre]

New research has found that inhibiting a specific protein, PRMT1, can inhibit the growth of kidney cancer cells by blocking the cells’ ability to repair DNA and replicate, which may lead to a novel therapeutic strategy in the treatment of kidney cancer.

https://t.co/rht3e9KBmB

[Structural Genomics Consortium (SGC) @thesgconline]

A fruitful collaboration with @laillesuhnrese1 and @Cool_Genes using the SGC's epigenetic #probes library. How did this work lead to the identification of the role of PRMT1 in clear cell renal carcinoma?
Find the preprint: https://t.co/j0RT0bRqWa

[Joe Walton @Cool_Genes]

@discoursive 😝 💃

[Structural Genomics Consortium (SGC) @thesgconline]

The SGC 20th Anniversary Symposium continues with @decarvalho_lab and @Cool_Genes, from @pmcancercentre @UHN, elucidating how probing the human epi(genome) have the potential to uncover therapeutic opportunities in cancer. #20yearsSGC

[Structural Genomics Consortium (SGC) @thesgconline]

SGC's 20th Anniversary Symposium is happening tomorrow! Looking forward to celebrating two decades of collaborative #openscience with esteemed scientists and research trainees.

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

The SGC 20th Anniversary Symposium @thesgconline is coming on March 8! The symposium will feature several talks on accelerating drug discovery in cancer, infectious diseases and more. Check out the event program here → https://t.co/v8Npn1SdwR

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

From an extensive traveller in her childhood, to a world-class head and neck cancer researcher, Dr. Laurie Ailles @pmcancercentre weaves her passion with hard work and adaptability to seize opportunities that come to her. Read her career & life story here
https://t.co/llTrLNRQhi

[Joe Walton @Cool_Genes]

Here we go… #CancerResearch #Maui

[Gabriel Malouf @GabrielMalouf]

Happy to share the discovery of the team of a novel epigenetic phenotype in clear-cell RCC charted by enhancer demethylation (TED), and associated with sarcomatoid dedifferentiation and resistance to IO. https://t.co/OSe0ChicPu @CCR_AACR @DrChoueiri @IGBMC @FondationARC @unistra

[Joe Walton @Cool_Genes]

The scandal of researchers paid less than a living wage https://t.co/gXdphC3KdG

[Joe Walton @Cool_Genes]

@SusanMarzolini Thank-you, Susan!

[Joe Walton @Cool_Genes]

"PBRM1, SETD2 and BAP1 -- The trinity of 3p in clear cell renal cell carcinoma"
https://t.co/WedEE9Wkwp

[Canadian Urological Association @CanUrolAssoc]

📚PUBLISHED BY #CUASF winner! #kidneycancerresearch #epigenetics PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma
>>https://t.co/igHm4aAsrz
@Cool_Genes @Lawson6Keith
@CherylArrowsmi1 @PrinosTakis
@UroOncMD @GabrielMalouf
@KidneyCancer_Ca @NatRevUrol