Together with @IdoAmitLab we’re very excited to introduce BiCE (Bispecific DC-T Cell Engager)- a new platform to engineer immune cell communication for #cancer#immunotherapy. Led by the amazing @yuval_shap@orenbarboy, now out @CellCellPress: https://t.co/COVWAN7Tbf
(1/11)
@csgarrix@NatureBiotech Congrats Chris! Great new strategy to therapeutically reprogram DCs function, and once again highlighting the central role of cDC1s in converting immune cold tumors into productive anti-tumor immune responses
Excited to share our new paper in Nature Immunology! 🦠🔬
https://t.co/bFpCUGRz38
We uncover a central role for intestinal stem cells in defending the tissue against Salmonella infection.
A huge thanks to all collaborators and team members who made this work possible!
Excited to share our new @biorxivpreprint from the lab!
We show that intestinal Lgr5⁺ stem cells are active luminal sensors that use apical TLR2 signaling to detect microbiota-derived cues and regulate epithelial differentiation and antimicrobial defense.
https://t.co/4ZtBRHGHab
Beautiful work demonstrating that intestinal epithelial MHC II presentation encodes tissue state to balance tolerance and inflammation. Congrats Moshe and all authors!
Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens.
https://t.co/j9lKSXVI35
What if we could turn the tumor’s deadliest tricks against it?
New @Cancer_Cell: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Led by @GalYagel, @D_Rimini & @MVLocquenghien (1/15)
https://t.co/dzBILa2o26
The SMR 2025 Annual Congress (Amsterdam Oct 25-28) covers basic, preclinical & translational melanoma research. It is a very enjoyable conference with top faculty and now improved with ample opportunity for young investigators to learn & network. Join us! https://t.co/xL2ot0TkAz
Exciting new paper from @IdoAmitLab lab! 🧬🔬
A deep dive into psoriatic arthritis reveals new clues and a promising path for therapy. Cutting-edge science with real translation potential!👇congrats guys!
Excited to share our study in @SciImmunology dissecting the immune landscape of psoriatic arthritis (PsA)—with a new finding: immunoproteasome overactivity drives treatment resistance🧵
Led by Reut Tzemach,Chamutal Gur,@TgSanPhan,Eyal David & team. (1/11)
https://t.co/LzTrjVfk7r
Reprogramming macrophages remains one of the outstanding unsolved challenges in cancer immunotherapy. Huge congratulations to @IdoAmitLab@FadiSheban and the team for tackling this complex task and publishing this impactful study.
We are excited to share our new study @Cancer_Cell identifying Zeb2 as a master genetic switch controlling the tumor-associated macrophage (TAM) program. Led by @FadiSheban, @TgSanPhan, @CuriousKX & @FlorianIngelfi1. (1/20)
https://t.co/ZpPXUjbwRF
Just published📢 Our new forum article on Fc-optimized checkpoint antibodies for cancer therapy. New to immunotherapy and antibody engineering? This one’s for you! Co-authored with Alan Korman. @TrendsMolecMed#CancerImmunotherapy#FcEngineering
https://t.co/y49YrGDSdr
Had a great time presenting our work and hearing about exciting new science at the 3rd @ImmunoSens - IFReC International School on Advanced Immunology in Japan. Thanks for the amazing opportunity 🙏🏼
@DahanLab