Dan Paull

Feuding with robots @nyscf. Opinions are my own.

[VFossati (she, her) @fossati_v]

Proud to see our image selected for the November @CellStemCell cover, spotlighting two papers from my lab and @Pluchinolab that showcase the power of patient stem cell-derived models to study multiple sclerosis. (1/2)

[New York Stem Cell Foundation Research Institute @nyscf]

Happening now at #ISSCR2024: NYSCF’s @RaekaAiyar announces our new partnership with @AllenInstitute to create a collection of tagged, ancestrally diverse stem cell lines with the aim of enabling inclusive quantitative cellular biology.

[Patrick Collison @patrickc]

I broadly agree with this post, which is very good. (And I share @RuxandraTeslo's ambivalence about our progress over the past 50 years.)

That said, wet lab experiments themselves are IMO a bigger bottleneck than trials. (This is why @arcinstitute is working on a virtual cell.) It's still far too slow and expensive to even come up with effective drug candidates, which is substantially a function of the time constants, complexity, and costs of dealing with cells and tissues. We need faster iteration and better predictive power in our preclinical models.

[New York Stem Cell Foundation Research Institute @nyscf]

How close are we to cures, and how are stem cells transforming human health? Tune in virtually on 12/5 at 11 AM ET to hear from NYSCF’s Dr. Daniel Paull about the exciting future of stem cell research. Register here: https://t.co/debZwZ6hrL

[New York Stem Cell Foundation Research Institute @nyscf]

This #GivingTuesday show your support for NYSCF and stem cell research by joining and sharing our upcoming virtual event. Learn about the revolutionary tools that could lead to new disease treatments sooner than you think. Register here: https://t.co/debZwZ6hrL

[Stem Cell Podcast @stemcellpodcast]

📢 Don't miss this live event with @NYSCF on August 3rd!

Three NYSCF leaders will discuss the organization's efforts to take down obstacles in stem cell research.

RSVP now: https://t.co/6hlfx37YR4

@RaekaAiyar @Laurandres @Dan_Paull

[VFossati (she, her) @fossati_v]

Today last year was the last time I saw you in person. Who could have known? What a wonderful presentation, bringing #nyscf to Greece. I like to keep the memory of us smiling, together. Missing you, Susan.

[Angelos Georgakis @angelosgeo]

Bench scientist to biotech CEO is a brutal transition.

6 key mindset shifts for the biotech leaders of tomorrow:

[Dan Paull @dan_paull]

@greally Congrats John!

[Dan Paull @dan_paull]

@DrAnneCarpenter Congrats Anne! What an amazing resource! We've been looking forward to this for a while!

[Dan Paull @dan_paull]

Congratulations @ChenShuibing, on this great publication. Happy to have played a role in getting those arrayed iPSC lines to you. This is the second big paper this year showcasing the power of automation and large-scale disease modeling, with more to come from the @nyscf team…

[Shuibing Chen @ChenShuibing]

Will iPSCs be a next model to study patient heterogeneity? Please read our new paper on #iPS cell based #GWAS on @CellStemCell

[Patrick Malone, MD PhD @patricksmalone]

hello world! first edition of techbio weekly review

https://t.co/tCsFznzLyD

[New York Stem Cell Foundation Research Institute @nyscf]

A touching obituary of our beloved founding CEO, Susan L. Solomon, in today's @nytimes:
“Vexed by lags in producing cures for diabetes and cancer, she helped raise $400M to start a foundation that has made breakthroughs in treating major diseases.” (1/n)
https://t.co/9MTSUtFH9w

[John Greally @greally]

Postdoc position available with my group to study the role of non-coding variants in neurodevelopmental diseases.

We have fascinating data that we want to pursue with iPSCs, brain organoids, CRISPR, molecular and cellular phenotyping.

https://t.co/UqBL8s1eWk
#postdocjobs

[Dan Paull @dan_paull]

And you get to work with some pretty cool tech! Lots of #Robots here @nyscf doing all sorts of cool things with #stemcells 🤖
Come help build our #software, #workflows while doing some great #biology along the way.

[Dan Paull @dan_paull]

Finally, a big thanks to the NYSCF comms team for doing such a great job with the original thread I quoted: hats off to @raekaaiyar, @CapelleraSandra, and the rest of the team for putting together such a great read! 10/10

[Dan Paull @dan_paull]

Last Friday marked another milestone in our effort to bring scale to human biology. Integrating #CellBiology with #automation, #Robotics, #softwaredevelopment, #DataScience & #MachineLearning we’ve been able to develop disease signatures for #Parkinsons in human cells. A 🧵: 1/10

[New York Stem Cell Foundation Research Institute @nyscf]

Drug discovery for complex diseases like #Parkinsons (#PD) is challenging - we need screenable cellular phenotypes to move faster. Today in @NatureComms, we present an #AI-driven phenotyping platform that identifies #PD hallmarks in patient cells: https://t.co/IQdinIjQJL 🧵(1/11)

[Dan Paull @dan_paull]

Importantly though, nothing we do @nyscf happens in a vacuum: it’s made possible because brilliant people push the limits of what we think is possible. This was exemplified by Reid Otto (1969-2022), who was not only a mentor but a great friend. This work is dedicated to you. 9/10