Yojet Sharma

Modeling neurodevelopmental disorders using human stem cells, specific interest in phosphoinositides & calcium @NCBS_Bangalore

[Yojet Sharma @JetYojet]

Neurons carry ~5,000–10,000 molecules of PI(4,5)P₂ per μm² of membrane (Bertil Hille, 2001). What happens to human brain development when that number changes? I address this in my PhD work using a disease-in-a-dish model of Lowe Syndrome: https://t.co/ux2AnGj9Az

[Samuel Hume @DrSamuelBHume]

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results

I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

[National Centre for Biological Sciences @NCBS_Bangalore]

#PhDone! 🎓Congratulations Dr Yojet!🎉
@JetYojet from Prof @RPadinjat's lab successfully defended thesis!

Read the full study here: https://t.co/hj5YxdfLSH

Scroll down to learn about his work on Physiological Maturation of Developing Lowe Syndrome Patient iPSC-derived Neurons.

[Deepa Rajan, PhD @DeepaHRajan]

How can a single cell learn without a brain? We explore this in my new paper with @WallaceUcsf! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny! 🧵1/n

[Katie Galloway @GallowayLabMIT]

So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? Come hear about STRAIGHT-IN Dual now out at Nature Biomedical Engineering! 🧵

Link at end!

[Alfonso Martinez Arias @AMartinezArias]

One of the clear, and significant findings derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneities at the level of gene expression (GE). https://t.co/gmvOEXfqIx 🧵

[Kaushal K. Vidyarthee @vidyarthee]

Rest in peace #RaghuRai — a legendary visual storyteller who captured the soul of India, taught us to see beyond the frame, and leaves behind a timeless legacy of powerful images

[Davide Piffer @DavidePiffer]

@doctorveera @Nature @aliakbari23 Thanks for your reply, and I didn't want to blame you for this. I have just posted an account of this dispute here: https://t.co/t7Hz8kbhsS

[Niraj Rai @NirajRai3]

Genome India Project is out. 59 of 83 populations show higher inbreeding than Ashkenazi Jew- signals that we are only seeing the tip of the iceberg; scaling this to over 4,900 communities has the power to fundamentally redefine global clinical genetics.
https://t.co/u7hetSLrXF

[Eye On Axis @eyeonaxis]

The greenman from Chadni Chowk. New Delhi, India | Nimit Nigham

[Gan Lab @LiGanLab]

Excited to share our new study identifying soluble DLK1 as a novel microglia-derived senescence factor. sDLK1 induced hypomyelination, oligodendrocyte dysfunction, & altered neuronal activity in iPSC-derived neurons @TheodorisLab @dsrivastava_md
https://t.co/G0lsEaibs9

[Tal Laviv @LavivTal]

I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain! https://t.co/AHTspCd5mU

[National Centre for Biological Sciences @NCBS_Bangalore]

#ResearchExplained
In a recent study @JetYojet & team from Prof @RPadinjat's lab have discovered a spike in a certain lipid in the brain linked to breakdown of smooth neuronal communication in patients diagnosed with Lowe Syndrome(LS)
Read: https://t.co/M2O16LSeb9
✏️@LittleMurthy

[ShorterLab @ShorterLab]

A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy: Neuron https://t.co/eICUK7a2wC

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Non-canonical roles of lysosomes in neurons
https://t.co/lrP28Q5WtS

[Raghu Padinjat പടിഞാററ് രഘൂ @RPadinjat]

Happy to share new research in EMBO Molecular Medicine (https://t.co/rjUeIgRQEV) from our group that reveals the underlying causes for the brain manifestations of Lowe syndrome, a rare genetic disorder affecting young boys.
(1/n)

[kris gopalakrishnan @kris_sg]

Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome | EMBO Molecular Medicine. Congrats @RPadinjat @NCBS_Bangalore
https://t.co/DEslLK8HIb

[National Centre for Biological Sciences @NCBS_Bangalore]

🧠 Publication Alert!
@JetYojet and team from @RPadinjat 's lab uncover how enhanced Notch-dependent gliogenesis and delayed maturation underlie neurodevelopmental defects in Lowe syndrome.
Read the paper 👉 https://t.co/hj5YxdfLSH
Congratulations to the team! 🎉

[Yojet Sharma @JetYojet]

@ventigers Thanks Venkat!

[Yojet Sharma @JetYojet]

Neurons carry ~5,000–10,000 molecules of PI(4,5)P₂ per μm² of membrane (Bertil Hille, 2001). What happens to human brain development when that number changes? I address this in my PhD work using a disease-in-a-dish model of Lowe Syndrome: https://t.co/ux2AnGj9Az

[Rohini Nilekani Center for Brain and Mind - NCBS @cbmncbs]

📢 Publication alert !

#LoweSyndrome is a rare #genetic disorder affecting the eyes, kidneys & the brain.

Team @cbmncbs has the first ever insightful findings into the brain defects with a potential to redesign therapy.

1/n