Neurons carry ~5,000–10,000 molecules of PI(4,5)P₂ per μm² of membrane (Bertil Hille, 2001). What happens to human brain development when that number changes? I address this in my PhD work using a disease-in-a-dish model of Lowe Syndrome: https://t.co/ux2AnGj9Az
One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results
I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore
#PhDone! 🎓Congratulations Dr Yojet!🎉
@JetYojet from Prof @RPadinjat's lab successfully defended thesis!
Read the full study here: https://t.co/hj5YxdfLSH
Scroll down to learn about his work on Physiological Maturation of Developing Lowe Syndrome Patient iPSC-derived Neurons.
How can a single cell learn without a brain? We explore this in my new paper with @WallaceUcsf! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny! 🧵1/n
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? Come hear about STRAIGHT-IN Dual now out at Nature Biomedical Engineering! 🧵
Link at end!
One of the clear, and significant findings derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneities at the level of gene expression (GE). https://t.co/gmvOEXfqIx 🧵
Rest in peace #RaghuRai — a legendary visual storyteller who captured the soul of India, taught us to see beyond the frame, and leaves behind a timeless legacy of powerful images
@doctorveera@Nature@aliakbari23 Thanks for your reply, and I didn't want to blame you for this. I have just posted an account of this dispute here: https://t.co/t7Hz8kbhsS
Genome India Project is out. 59 of 83 populations show higher inbreeding than Ashkenazi Jew- signals that we are only seeing the tip of the iceberg; scaling this to over 4,900 communities has the power to fundamentally redefine global clinical genetics.
https://t.co/u7hetSLrXF
Excited to share our new study identifying soluble DLK1 as a novel microglia-derived senescence factor. sDLK1 induced hypomyelination, oligodendrocyte dysfunction, & altered neuronal activity in iPSC-derived neurons @TheodorisLab@dsrivastava_md
https://t.co/G0lsEaibs9
I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain! https://t.co/AHTspCd5mU
#ResearchExplained
In a recent study @JetYojet & team from Prof @RPadinjat's lab have discovered a spike in a certain lipid in the brain linked to breakdown of smooth neuronal communication in patients diagnosed with Lowe Syndrome(LS)
Read: https://t.co/M2O16LSeb9
✏️@LittleMurthy
A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy: Neuron https://t.co/eICUK7a2wC
Happy to share new research in EMBO Molecular Medicine (https://t.co/rjUeIgRQEV) from our group that reveals the underlying causes for the brain manifestations of Lowe syndrome, a rare genetic disorder affecting young boys.
(1/n)
🧠 Publication Alert!
@JetYojet and team from @RPadinjat 's lab uncover how enhanced Notch-dependent gliogenesis and delayed maturation underlie neurodevelopmental defects in Lowe syndrome.
Read the paper 👉 https://t.co/hj5YxdfLSH
Congratulations to the team! 🎉
Neurons carry ~5,000–10,000 molecules of PI(4,5)P₂ per μm² of membrane (Bertil Hille, 2001). What happens to human brain development when that number changes? I address this in my PhD work using a disease-in-a-dish model of Lowe Syndrome: https://t.co/ux2AnGj9Az
📢 Publication alert !
#LoweSyndrome is a rare #genetic disorder affecting the eyes, kidneys & the brain.
Team @cbmncbs has the first ever insightful findings into the brain defects with a potential to redesign therapy.
1/n