David Clinkard M.D

Physician, FRCPC anesthesia, FRCPC pain medicine, FIPP. love human performance and health (and occasionally swimming and biking).

[Eric Topol @EricTopol]

No, the peptide craze is not backed by science.
"What people are shooting up with out there I would give to mice."
“The influencer crowd has sort of created this perception that these are miracle drugs."— @mkaeberlein
New feature @nature
https://t.co/o0CHojoFNj

[David Clinkard M.D @DavidClinkard]

@afshineemrani Would you be able to share any peer reviewed, human trials for bpc-157? Or any pre clinical studies independent of the Croatia group?

[David Clinkard M.D @DavidClinkard]

@agingdoc1 @davidasinclair Doesn’t this also show that NR had no benefit as compared to NR vs exercise?

[David Clinkard M.D @DavidClinkard]

@bmansari1 Jay looks like he’s enjoying it

[David Clinkard M.D @DavidClinkard]

@MedBonnevie I suspect with a 660 baseline he had a significant component of macrotroponin.

https://t.co/LSv8LwX8NE

[Delgoffe Lab @DelgoffeLab]

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ https://t.co/zACqCLxDMU

[David Clinkard M.D @DavidClinkard]

Massive loss to medicine, truely a pioneer in cardiology

[Evandro Martins F. MD @evandrofilhobr]

With deep sorrow, I received the news of Dr. Eugene Braunwald’s passing, one of the greatest figures in world cardiology.

His scientific legacy, clinical vision, and immeasurable contribution to generations of cardiologists will continue to live on in our daily practice and in the history of medicine.

My heartfelt condolences to his family, friends, students, and to the entire cardiology community. May he rest in peace.

[Evandro Martins F. MD @evandrofilhobr]

With deep sorrow, I received the news of Dr. Eugene Braunwald’s passing, one of the greatest figures in world cardiology.

His scientific legacy, clinical vision, and immeasurable contribution to generations of cardiologists will continue to live on in our daily practice and in the history of medicine.

My heartfelt condolences to his family, friends, students, and to the entire cardiology community. May he rest in peace.

[David Clinkard M.D @DavidClinkard]

@BradStanfieldMD Fascinating work and amazing job. What are your thoughts on that crp rise?

[David Clinkard M.D @DavidClinkard]

@RheumNow What are your thoughts on the infection risk? Any idea how that compares to alternative options (other jak vs Ivig vs mmf etc)?

[David Clinkard M.D @DavidClinkard]

@CharlesMBrenner So if it is homeostatic during illness doesn’t that suggest supplementing/changing the system could have unknown consequences? (I wonder about signalling to virus/bacteria) I’m really quite curious here because I wonder about NK inhibitors such as 78c.

[David Clinkard M.D @DavidClinkard]

@shawnhamby @Papa_Heme @BrentAWilliams2 If you look at the learning literature, we make connections mostly after we have memorized the knowledge. If we don’t have a massive base, how do we a) know what the LLMs are making is true, and b) come up with new insights ourselves?

[The New Yorker @NewYorker]

“I was neither angry nor scared. It simply was. It was a fact about the world, like the distance from the sun to the Earth.” Revisit an excerpt from Paul Kalanithi’s posthumously published memoir about his battle with metastatic lung cancer, “When Breath Becomes Air”: https://t.co/GhgW1vcRFm

[tree-leaves-blue @treeleavesblue1]

Noah Wyle has an important public service announcement - from JKL tonight

[David Clinkard M.D @DavidClinkard]

@MasriAhmadMD I was always surprised by failure of the trimetazidine studies in nohcm. Energetically it makes sense, so I hope the phase 3 data supports it. I do suspect the positive sglt2i data in HCM is due to weight loss/metabolic changes that outweigh the fatty acid oxidation changes

[David Clinkard M.D @DavidClinkard]

@Rheumat_Aravind What’s the role of complement in dermatomyositis? Do you follow it for treatment?/diagnosis??

[David Clinkard M.D @DavidClinkard]

@Rheumat_Aravind @abdelhamed012 @FranLoachamin @IhabFathiSulima What is the role of complement in dermatomyositis?