Deivid Rodrigues

RNA biologist trying to understand how the world works.

[Deivid Rodrigues @Deivid_80]

@Alan_Couzens 5000+ kcals/day on Z2 workouts? How sir?

[Deivid Rodrigues @Deivid_80]

@Fraser_mccready Congrats!

[Deivid Rodrigues @Deivid_80]

Cellular “cruise control” system safeguards RNA levels in Rett syndrome nerve cells https://t.co/cjzlGOBnq1

[Xi Huang @XiHuang18]

We are thrilled that our blood-tumor barrier (BTB) paper is featured on the cover of @NeuroCellPress! In this paper https://t.co/5vQ0IJy91X, we show that tumor cells project cellular processes to ensheathe blood vessels to form the BTB in medulloblastoma.

[Fraser McCready @Fraser_mccready]

The latest publication from the Ellis lab, and the first of hopefully many more MEA-related research papers to come out of our fruitful collaboration with @JulioMTNeuro. Big congratulations to everyone involved in this work!

https://t.co/VM7Omvmjqv

[Sam Payne @byu_sam]

"Therefore, mRNA levels should not
be interpreted as the final output of gene expression.
Instead, it is more instructive to think of mRNAs as what
they mechanistically are: the templates for protein synthesis."

https://t.co/jRtBsQ2D4z

[Bin Gu @BinGu31824822]

Any mouse genetic tools needs to be tested and refined with many targets. We are distributing the TIR1 mouse lines through Canadian Mouse Mutant Repository(CMMR) and my Lab ([email protected]). Help develop exciting AID mouse tools by using it on your favorite targets.

[Bin Gu @BinGu31824822]

https://t.co/jkLLijryRY @eLife. Happy to share our new publication. We showed that the Auxin Inducible Degradation (AID) system can be used to manipulate endogenous proteins in live mice. A big thanks to @AndrewWoodLab for great collaboration!

[Karun K Singh @karunsinghneuro]

Our lab is hiring! Come join us in Toronto at the Krembil Research Institute @KrembilRI @UHN

Who? Postdoctoral Fellows and Research Technician

We use mouse in vivo and human iPSC-3D organoid models, and multi-omics, to study neurodevelopmental and neurodegenerative disorders

[The Blencowe Lab @ U of T @Blencowe_Lab]

Out now: RNAs associated with diverse nuclear domains revealed by proximity labeling. Outstanding team effort including @rassobar @Miller_MKWu @u_braunschweig & collaborators @NucleomeHunter @gingraslab1 & ex lab member Rob Weatheritt @Neuro_RNA. https://t.co/XDDLplc0SC 1/4

[Fraser McCready @Fraser_mccready]

Excited to share this review prepared jointly by the James Ellis and @JulioMTNeuro labs, published online today at @Biology_MDPI. Here, we discuss the use of in vitro multielectrode array technology in iPSC models of neurodevelopmental disorders.

(A long thread 🧵)

[Deivid Rodrigues @Deivid_80]

@MrKarunhands @NU_CDB @NUSynBio 👊 keep in touch, that’s the kind of stuff I study.

[Deivid Rodrigues @Deivid_80]

@MrKarunhands @NU_CDB @NUSynBio 2) Could the lack of correlation be caused by counteracting mRNA decay mechanisms, since you’re only looking at steady-state mRNA levels you cannot distinguish. I bet mRNA decay might have a role there
https://t.co/N7pdOZ1doF

[Deivid Rodrigues @Deivid_80]

@MrKarunhands @NU_CDB @NUSynBio But by the book, ‘expression’ should be reserved for transcription. This brings me to my questions: 1) what about the correlation between the accessibility peaks and actual transcription activity (measured by GROseq or similar)? Would you have a stronger correlation there?

[Deivid Rodrigues @Deivid_80]

@wbderry That’s sophistication, and hits home too

[Deivid Rodrigues @Deivid_80]

@neelmukherj @slavov_n Same pain here.

[Deivid Rodrigues @Deivid_80]

@wbderry @ScienceAdvances Congrats @wbderry and @AishSub1.

[Deivid Rodrigues @Deivid_80]

And last but not least, my twitterless supervisor James Ellis for fully embarking on the #RNAbiology boat with me! 16. End

[Deivid Rodrigues @Deivid_80]

I am delighted to share the newest bioRxiv preprint from the James Ellis lab @SKDevStemCell program @sickkids @SickKidsNews - Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models https://t.co/N7pdOZ1doF 1/n

[Deivid Rodrigues @Deivid_80]

I’d like to acknowledge the work of many people, especially my co-first author Marat for the incredible computational biology work, funding agencies, and Brian Kalish @briankalishMD for helping with comments to the manuscript. 15/n