Thanks to @ginny_farias and @JKlumperman for the supervision during this project. Also major thanks to the co-authors @Anna_E_George , Tineke Veenendaal, Suzanne van Dijk, Frederik Verweij for the collaborative effort!
🧵These APP-CTFs were subsequently secreted via small vesicles called exosomes as a form of waste management - a process that could potentially contribute to disease propagation in Alzheimer's Disease
https://t.co/YKn0ER4z5v
POTATOMap is officially out today (even tho it says 2024-12-30)… long story 😂
Constructs are available on addgene and POTATOMap data is available on PRIDE repository.
Thank you so much to everyone involved!!
The latest preprint from our lab. Congratulations to the first author @EdenJess and thank you to all our wonderful collaborators. @TheCIMR @CellBiol_MRCLMB @JLS_Lab
Yesss!! It's out in @Dev_Cell!🥳Check it out to see lots of new exciting data on the axonal ER and local translation compared to the pre-print. Thanks to the reviewers for their insights that helped improve this study. And many thanks to all involved, a real team effort!
It's out!😭🕺First preprint as a PhD at the Farias Lab @ginny_farias where we investigated biosynthetic lysosomal membrane protein trafficking, delivery and interactome with Protein Origin, Trafficking And Targeting to Organelle Mapping (POTATOMap)🥔
https://t.co/vmiYfjIx7F
Had a great discussion about our work on endolysosomal dysfunction with aging at the https://t.co/RFZLcHpDlI conference. Thanks @JKlumperman for the invitation! I was impressed with the students so active in the Q&A! Especially discussing App traffic with @DerkDraper!
Very happy to share our perspective article on polarized protein secretion in neurons! We explore each step in the sorting process, from ER to PM, highlighting the latest insights. @ginny_farias
https://t.co/WPJeADx82y
📢Up for an exciting PhD journey at the crossroads of high-resolution electron microscopy🔬and cancer biology🧬?
We have an open #PhD position on "Nanoscale imaging of cancer organoids"
🔬🥼🧪🧫🧬
https://t.co/AuFUNapDqO
#phdpositions
Want to make some ORANGE CAKE? My first publication with @hdmacgillavry, Arthur de Jong and @Jelmerwillems is fully online! Duplex Labeling and Manipulation of Neuronal Proteins Using Sequential CRISPR/Cas9 Gene Editing https://t.co/F1lqtkRz1F. Here are the key messages🧵
Early Endosome Capture Proteomics and its Application to Amyloid Precursor Protein Intramembrane Processing by β and γ-Secretases https://t.co/yK5WCxIdUE #biorxiv_cellbio