LCH_Hei

Lysosomes|Neuronal Organelle|UU PhD Candidate|Farías lab|Utrecht University|Cell Biology|MPhil. Life Science HKUST

[LCH_Hei @L_CHei]

https://t.co/YKn0ER4z5v

POTATOMap is officially out today (even tho it says 2024-12-30)… long story 😂

Constructs are available on addgene and POTATOMap data is available on PRIDE repository.

Thank you so much to everyone involved!!

[LCH_Hei @L_CHei]

It's out!😭🕺First preprint as a PhD at the Farias Lab @ginny_farias where we investigated biosynthetic lysosomal membrane protein trafficking, delivery and interactome with Protein Origin, Trafficking And Targeting to Organelle Mapping (POTATOMap)🥔

https://t.co/vmiYfjIx7F

[LCH_Hei @L_CHei]

Check out the preprint from Noortje investigating how polarised trafficking of neuroligin works in neurons. #POTATOMap_strikes_again~ Congrats to Noortje and everyone involved!

[Noortje Kersten @KerstenNoortje]

The main project of my PhD: "Spatiotemporal proteomics elucidates trafficking and localization of Neuroligins to the axon initial segment plasma membrane" is now on BioRxiv! Thanks to all collaborators🤝https://t.co/9ujbH3gzqF

[Noortje Kersten @KerstenNoortje]

Our manuscript on the role of the calsyntenin adaptors in biosynthetic axonal transport is on BioRxiv now: https://t.co/mKNr2KpemU

It was a pleasure to work on this with my colleague and friend @DerkDraper . Special thanks to @JKlumperman and @ginny_farias for their support.

[Nature Chemical Biology @nchembio]

Membrane editing with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles

https://t.co/kCOZ8NWfB5

[Derk Draper @DerkDraper]

I am happy to share our work on the role of the HOPS complex in APP trafficking and processing! 💫 Out now on bioRxiv:
https://t.co/AAwLzQEEEo

[Ha Nguyen @HaNguyen1107]

Excited to share our preprint, now available online on BioRxiv! https://t.co/LjayTn0d6b. We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.

[Kristina @jekriste]

To anyone who were excited for the release of SUM-PAINT, we now published a detailed protocol on to how replicate it in your hands! Check it out here: https://t.co/Wm8V3KuOhy

Thanks to @EduardUnterauer @EvaSchentarra @JungmannLab @euforna

[Austin E. Y. T. Lefebvre @Austin_Lefebvre]

Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods!

Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy

🧵1/N

[Jungmann Lab @JungmannLab]

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS  🧬🎨🍬

The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy

https://t.co/ukJcD7aZsE

[Journal of Cell Biology @JCellBiol]

Sanzà, Klumperman et al. @UMCUtrecht reveal a novel role of VPS41 in cellular trafficking, showing that it recruits biosynthetic LAMP carriers in a process dependent on the small GTPase Arl8b. https://t.co/3iyg6XcN77

#Organelles #Trafficking

[Cell Biology J-Club @cell_club]

VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b https://t.co/gkjeORq2vy

[Journal of Cell Biology @JCellBiol]

Korsten, Kapitein et al. @UniUtrecht employ live cell imaging and expansion microscopy to show that nuclear polyQ aggregates associated with #HuntingtonDisease induce nuclear envelope (NE) blebbing and cause NE ruptures. https://t.co/xHcReT6jPp

#Disease #Membrane

[James Manton @JamesDManton]

We present:

'Multispectral live-cell imaging with uncompromised spatiotemporal resolution'.

https://t.co/SXCLXYJ74z

1/16

[Bo Gong @Bo_Gong_]

Excited to share our new @Nature article reporting a novel cell polarity mechanism, mediated by contacts between the endoplasmic reticulum (ER) and plasma membrane (PM). Article: https://t.co/VRf5QIVkhG

[Max Koppers @MaxKoppers]

Yesss!! It's out in @Dev_Cell!🥳Check it out to see lots of new exciting data on the axonal ER and local translation compared to the pre-print. Thanks to the reviewers for their insights that helped improve this study. And many thanks to all involved, a real team effort!

[Developmental Cell @Dev_Cell]

Online now: Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions https://t.co/c3hpra4LJd

[LCH_Hei @L_CHei]

@ginny_farias

[LCH_Hei @L_CHei]

@psychescope

[LCH_Hei @L_CHei]

@AgChaigne @ginny_farias

[LCH_Hei @L_CHei]

@AgChaigne @ginny_farias We are in the Netherlands, the land of potatoes 🥔🫢🇳🇱 Fun fact did you know Rabobank also has a potato map as well about world potato import/export?

https://t.co/r15GSnUNEo