The Dobreva Lab

We study the interplay between genetics and epigenetics in shaping cell identity, plasticity, and resilience during development and in disease.

[nature @Nature]

New-found immune cells called ‘ruptoblasts’ explode when triggered, ejecting toxic chemicals capable of delivering death to surrounding cells in just minutes. The cells’ discoverers say that this process, which they call ruptosis, seems to be a new form of cell death.

https://t.co/6JtcC1HjY0

[nature @Nature]

Nature research paper: Human haematopoietic stem cells remember inflammatory stress

https://t.co/IEjvoUw1DX

[Jane Skok @jane_skok]

New preprint from the Skok lab

[Waggoner Lab @LabWaggoner]

Differential assembly of mouse and human tumor microenvironments @NatImmunol @CourauTristan @MaxKrummel @UCSF
https://t.co/G9rLz6KiNO

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[Science Advances @ScienceAdvances]

Memory-encoded magnetic probiotic microbots soften tumor microenvironments and allow for deeper penetration and boosted tumor treatment. https://t.co/EHPwSckIAr

[Cell Metabolism @Cell_Metabolism]

New! Online now: Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling https://t.co/KPL99JFSPN

[Cell Metabolism @Cell_Metabolism]

Iron-dependent brain reshaping links social isolation to anxiety https://t.co/Rf3axhqAuk

[Cell Metabolism @Cell_Metabolism]

Exercise as a therapeutic intervention for long-lasting and chronic diseases https://t.co/XoUod6jd10

[MIT Dept of BE @MITdeptofBE]

In a new study, @Anders_S_Hansen Lab have measured chromatin movement at timescales ranging from hundreds of microseconds to hours, allowing them to rigorously quantify those dynamics for the first time. https://t.co/PqRFEPHjVs @NatureSMB

[Eric Topol @EricTopol]

Our best shot for preventing many diseases?
Exercise
A @Cell_Metabolism new review
https://t.co/axi6aUDpZ7

[Nature Cancer @NatureCancer]

⭐️Don't miss this Review published @NatureCancer
as part of our Series on Tumor Heterogeneity and Plasticity

'Heterogeneity and plasticity of cancer-associated fibroblasts'
✒️By Ruth Scherz-Shouval, Mara Sherman and co-authors

🔗https://t.co/Qo6oplbnVx

[Mike Lustgarten, PhD @mike_lustgarten]

Butyrate extends health and lifespan in mice with mitochondrial deficiency

https://t.co/5vJ3r12Ex0

[Dr. Thomas Ichim @exosome]

Anyone interested in the future of #cancer therapy must read this’

it’s best summary of latest
findings of how brain controls cancer

https://t.co/DaBFIRmvrE

[Cancer Cell @Cancer_Cell]

Online Now: When tissue tension creates a mutagenic niche https://t.co/JU0gK6mrWP

[nature @Nature]

Almost all organs and tissues in the body can develop tumours, but those that affect the heart are seldom observed
https://t.co/wgJfes1ggU

[nature @Nature]

High levels of micro- and nanoplastics around brain tumours might indicate breakdown of the blood–brain barrier

https://t.co/WZ0JTw8YTa

[Eric Topol @EricTopol]

🆕 @ScienceMagazine
How do our cells have long term memory of inflammation that can later lead to persistent, chronic inflammation and disease?
Through specific epigenetic chromatin changes, aka "memory domains" @ScienceVisuals
https://t.co/mt70OwH144
https://t.co/DMk7SaIuBc

[Cell @CellCellPress]

Now online! Hyperinnervation inhibits organ-level regeneration in mammalian skin https://t.co/tmJgGuYig6

[Cell @CellCellPress]

This issue features a Review synthesizing latest on RNA modifications research
https://t.co/Q5zzhGHMku