Jonas Bille Nielsen

Physician scientist with interest in genomics, cardiovascular and metabolic diseases.

[Niek @Niek_verweij]

Our discovery of mutations in the CIDEB gene that protect against liver disease is published in @NEJM, leading to possible #RNAi therapeutics for NASH by Regeneron & Alnylam. 🚨
https://t.co/Y1PSQz9K3i

A short summary of the key findings 🧬🧵↓

[Mari Løset @MariLoeset]

We are announcing a PhD Fellowship in dermatology and biostatistics at K.G. Jebsen Center for Genetic Epidemiology @NTNU_ISM! 🎉

You will be exploring serum metabolites from @theHUNTStudy for improved prevention and treatment of psoriasis and eczema.

[Regeneron Genetics Center @RegeneronDNA]

Our latest research identified mutations in the CIDEB gene that are highly protective against nonalcoholic forms of liver disease. We're using this discovery to bring potentially promising new therapies to the clinic to help people with NASH. #RGCResearch

[Regeneron Genetics Center @RegeneronDNA]

By studying the genome of ~540K individuals, we discovered that those with a mutated copy of the CIDEB gene have a 53% lower risk for NASH. Discover how we use this research to inform the development of potential therapies. #RGCResearch

[Kirstin Ferguson @kirstinferguson]

The clever people at @NASA have created this deceptively simple yet highly effective data visualisation showing monthly global temperatures between 1880-2021. Watch until the end...

Learn more here - https://t.co/yvLKEgcIZ7

#ClimateEmergency #ClimateCrisis #climate

[Jonas Bille Nielsen @DrJBille]

https://t.co/XaOwHE1V0W

[Regeneron Genetics Center @RegeneronDNA]

The DNA asked who RNA was bringing to the holiday party❄️Can you guess their response?

[Jonas Bille Nielsen @DrJBille]

What a milestone in genomics.

[Goncalo Abecasis @gabecasis]

This paper was a longtime coming. In no particular order, some of the interesting things to learn from the sequencing and analysis of 53,831 human genomes. 1/n

https://t.co/N5xBtfOEbw

PDF: https://t.co/DRUQlztmGt

[U-M Health Frankel CVC @umichCVC]

NEW today in @NatureComms from @cristenw and colleagues: Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
https://t.co/hKoHEEL4o9

[Nature Genetics @NatureGenet]

Exploring and visualizing large-scale genetic associations by using PheWeb (Gagliano Taliun et al.) https://t.co/mNpy1ZSwT1

[Jonas Bille Nielsen @DrJBille]

Help track #COVID19 #COVID19DK in Denmark @SSI_dk.

[Statens Serum Institut @SSI_dk]

CORONAVIRUS. Statens Serum Instituts system til overvågning af influenza omfatter nu også COVID-19. Og vi har brug for din hjælp til at kortlægge, hvordan coronavirussmitten udvikler sig ude i samfundet https://t.co/mqWcv2aYSL #SSI #Coronavirus #Sundhed #Influenza #dkpol #sundpol

[Jonas Bille Nielsen @DrJBille]

Early RCT: no effect of of Lopinavir–Ritonavir vs. standard care in adults hospitalized with severe covid-19 in China (n=199).
~20% in-hospital mortality despite mean age 58y😟
https://t.co/Jdk7ZcHKbr

[Jonas Bille Nielsen @DrJBille]

#stratifiedlockdown for #COVIDdk #COVID19 seems reasonable next step. Current data suggest very low case fatality rate for previously healthy people <50y.

[Miguel Hernán @_MiguelHernan]

Europe and US in total or partial lockdown to mitigate #COVID19.

Soon more hundreds of millions will be confined to their homes. Huge personal sacrifices. Staggering economic losses.

Ok, we accept the price for the common good. But how does this end? Here are some strategies:

[Jonas Bille Nielsen @DrJBille]

@SoerenLK AFIB + ischemia (not VT, narrow QRS seen in V1).

[Joshua G. Schraiber @jgschraiber]

Can I suggest we just use the acronym PGS for Polygenic Score instead of PRS? The word "risk" though it has a basically precise statistical definition has a terrible connotation in general parlance. #ASHG19

[Brooke N. Wolford, PhD @bnwolford]

Planning your #ASHG19 Friday yet?! I’m as biased as euro PRS applied across ancestries, but highly suggest “Transferability of PRS Across Populations” @ 9 AM in Hall B. I’m co-moderating talks by @popgenepi, @genandgenes, my @umichsph colleague Pedro Orozco del Pino, & @dudutchy!

[Brooke N. Wolford, PhD @bnwolford]

Former @LabWiller postdoc @DrJBille is presenting his work on loss of function variants’ effects of liver related blood traits #ASHG19