Ed Esplin, MD, PhD

Clinical Geneticist FACMG CGAF FACP | SVP Med Affairs @Biocartis | Founder @ Stealth Startup | Med. Officer @Invitae (exit) | @UTSWMedCenter @UUtah posts own

[Ed Esplin, MD, PhD @EdEsplin]

#HuBMAP Data Portal: a resource for #multimodal #spatial & #singlecell data of healthy human tissues

The NIH Human BioMolecular Atlas Program (#HuBMAP) Data Portal (https://t.co/2bskIbF1AS)
9,316 public datasets
26 data types
29 organ classes

Including #largeintestine/#colon & #smallintestine/#smallbowel led by @Stanford #HuBMAP #TissueMappingCenter/#TMC @TheSnyderLab

https://t.co/GAX6yboWk4 #MorganTurner et al @_hubmap @NatureComms

[CGA-IGC @CGAIGC]

🏆 Maureen Mork from @UTMDAnderson was not only the very deserving recipient of the 2026 Dennis J. Ahnen Outstanding Service Award at #CGAIGC26, but also delivered an insightful presentation on an important topic, "Novel Approaches to Genetic Testing."

Ms Mork shared insights into the ongoing challenge of low cascade genetic testing uptake among at-risk relatives and explored potential strategies to improve participation.
🔹 Innovative approaches include patient navigation, reducing financial barriers, and at-home genetic testing.
🔹 No single intervention has consistently achieved the desired results, highlighting the need for creative, multimodal approaches to improve testing uptake.

🎥 Watch this short interview 👇to hear Ms Mork's key takeaways and what they mean for the multidisciplinary #hereditarygicancer care team.
#CascadeTesting #GeneticCounseling

[CGA-IGC @CGAIGC]

📣We're excited to kick off #PancreaticCancerAwarenessMonth & sharing exciting advances in pancreatic cancer treatment!

At #CGAIGC26, Dr. Lindsay Davis, a medical oncologist from the @CUCancerCenter highlights emerging treatment options, including PARP inhibitors, immunotherapy, & promising new KRAS-targeted therapies.

With KRAS mutations found in approximately 93% of pancreatic cancers, these developments offer new hope for more personalized treatment approaches & improved patient outcomes.

📽️Watch this short sound bite 👇 to hear Dr. Davis share the latest developments & what they could mean for patients!

[CGA-IGC @CGAIGC]

🎥 Does AI-assisted colonoscopy improve lesion detection in patients with #LynchSsyndrome?

At #CGAIGC26, @RHuneburg from University Hospital Bonn, Germany, shares findings from the CADLY-2 trial, published in The Lancet Gastroenterology & Hepatology

Watch this short video 👇 to hear the key findings and their implications for Lynch syndrome surveillance.

#hereditarygicancer

[CGA-IGC @CGAIGC]

All ready for Jeopardy! 🥳 #CGAIGC26

[CGA-IGC @CGAIGC]

🎥 Missed the Randall Burt Lecture at #CGAIGC26 or couldn't join us in Denver?

🙏to our Communications Committee member Benjamin Lerner, MD who caught up with James Ford, MD following his Randall Burt Lecture, “A Pre-Cancer Atlas for Hereditary Colorectal Cancer: Using FAP as a Model System.”

🧬 In this insightful interview, Dr. Ford shares insights into how familial adenomatous polyposis (FAP) can serve as a model for understanding the earliest stages of colorectal cancer development and the potential implications for future cancer prevention strategies.

🎧 Take a few minutes to listen to this fascinating conversation and hear directly from Dr. Ford!

#HereditaryGICancer #CancerResearch
@MSpringerGC @EdEsplin @asaf_maoz @HHampel1 @AparajitaSingh0

[Ed Esplin, MD, PhD @EdEsplin]

Privileged to join #DrJimFord @Stanford & #DrSteveGruber @cityofhope at the @CGAIGC #RandallBurtLecture highlighting work done by the @Stanford #PreCancerAtlas for #FamilialAdenomatousPolyposis #CGAIGC26

[Ed Esplin, MD, PhD @EdEsplin]

@Stanford @Nature @NIH Dr. Ford highlighted that all #FAP multiomic data, generated by the amazing @Stanford #PreCancerAtlas #FAP team is available at https://t.co/tS3C5x3Guh
Great opening for @CGAIGC Annual Meeting's 30th Anniversary! #CGAIGC26

[Ed Esplin, MD, PhD @EdEsplin]

Dr. Jim Ford presents @Stanford #PreCancerAtlas #FAP as #DrRandallBurt Lecture,
"A Pre-Cancer Atlas for Hereditary #ColorectalCancer Using #FamilialAdenomatousPolyposis as a Model System: #MultiOmic Analysis Toward #Prevention of #CRC"
to a packed house at @CGAIGC #CGAIGC26

[Ed Esplin, MD, PhD @EdEsplin]

@Stanford @Nature @Stanford #PreCancerAtlas #FAP acheived the ultimate goal of @NIH #HTAN using #spatial #transcriptomics & #proteomics to generate a #multiscale #3D #atlas of an #FAP #polyp #Han et al

[CGA-IGC @CGAIGC]

Dr. James Ford delivers the Randall Burt Lecture, “A Pre-Cancer Atlas for Hereditary Colorectal Cancer: Using FAP as a Model System.” #CGAIGC26

[Heather Hampel @HHampel1]

@thegimonster & @IdosGreg with Dan Luba announcing the recipients of the @projectDNA_org @cityofhope Clinical Cancer Genomics Community of Practice scholarships. Training the future generation of cancer genetics experts! #CGAIGC26

[Ed Esplin, MD, PhD @EdEsplin]

#Genetictesting is an integral part of the evaluation of children w/ #cardiomyopathy

30-50% pediatric #patients w/ #HCM #RCM #DCM #LVNC have PGVs on #genetictesting

growing number of #genetherapies strengthens the case for early #genetic diagnosis, as #genetictesting increasingly determine not only prognosis but also #treatment

Critical to ensure that the benefits of #genetictesting reach all children w/ #cardiomyopathy & their families

cit. "Comprehensive #GeneticTesting for #Pediatric #HypertrophicCardiomyopathy Reveals Clinical Management Opportunities & Syndromic Conditions" #DanaGal et al #PediatricCardiology @SpringerNature https://t.co/zGnHWOmfDt

#Universal #germline #genetictesting for all #patients w/ #cardiomyopathy

#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention

https://t.co/z1IF0BT224 #IulianaZaharia et al #Genes @MDPIOpenAccess

[CGA-IGC @CGAIGC]

🔬 5 presenters. 5 research perspectives. One shared goal: improving Lynch syndrome care.

Discover the research featured in the CCARE Lynch Syndrome Poster Walk at #CGAIGC26!

📌 Meet the presenters and explore their work:

🔹 Guillermo Alberto
Clinical and Molecular Characterization of Lynch Syndrome: Experience from an Argentinian Specialized Oncology Center

🔹 Alessandro Mannucci
Impact of Cecal Retroflexion on Adenoma Detection for Lynch Syndrome Surveillance Colonoscopy

🔹 Devang Namjoshi
How Are Patients with Lynch Syndrome (LS) Informed About Aspirin (ASA) Chemoprevention by Genetic Counselors (GCS), and What Factors Influence Communication Behaviors?

🔹 Desha Perera
Downstream Uptake of Cancer Risk Management Among Lynch Syndrome Patients

🔹 Drew Pitter
Building a Lynch Syndrome Specific Psychosocial Support Program: Practical Lessons from a Psychologist Led Group Model

📅 November 2 | 3:05 – 3:35 PM

🔗 Explore the scientific program: https://t.co/JUzCmuDA4r

[CGA-IGC @CGAIGC]

🏆 The champions are back… but can they defend their title?

An annual #CGAIGC26 favorite returns to Denver, and the competition is heating up! 🔥

The Lynch Pins and Frameshift Express are ready to challenge the defending champions, The Uninhibited Checkpoints, in this year’s CGA-IGC Jeopardy!

📅 November 3 | 5:00 – 6:00 PM
🔗 Explore the scientific program: https://t.co/JUzCmuDA4r

Proudly supported by Ambry Genetics, a Tempus company.

[CGA-IGC @CGAIGC]

How are advances in treatment, prevention, and surgical care changing the management of polyposis syndromes?

At #CGAIGC26, Dr. Leah Biller, Dr. Jeongyoon Moon, and Dr. Ajay Bansal will explore evolving approaches to polyposis care, from therapy-associated polyposis and functional outcomes following colorectal surgery to the latest evidence in chemoprevention.

🔗 Learn more about our speakers and their presentations:

Dr. Leah Biller: https://t.co/ze0xoF4Jrl

Dr. Jeongyoon Moon: https://t.co/ouhcqTpyfz

Dr. Ajay Bansal: https://t.co/7NDLBSOWfI

📅 November 4 | 10:45 AM – 12:15 PM