Feng Shan

Systems Immunology, single-cell genomics

[Adam Rubin @adamjrubin]

Excited to share our study of T cell signaling, where we directed high-content, single-cell genetic screening to uncover how a single adapter protein orchestrates a complex cellular process essential for health. (1/14)

https://t.co/MmGF01YVLn

[Tony Cillo, PhD @tonyrcillo]

Excited to share our paper out today in @CellCellPress with @BcellBruno @Vignali_Lab! Part of a trio of papers, we show in #Melanoma, anti-PD1+anti-LAG3 therapy modifies CD8 differentiation to promote enhanced effector function https://t.co/FwuxRuOPJI

[Sizun Jiang @SizunJ]

Wanna dissect host-microbiome interactions in situ? Incredibly excited to share work from @BokaiZhu with @GarryPNolan, and @shaleklab @MikeAngeloLab @yeoyaoyu @xavi_r_c @hanimal725 and others

[Shalek Lab @shaleklab]

Latest from the lab! Defining how cells adapt to chronic stress, uncovering long-term tradeoffs/repercussions, and predicting + validating causal factors - see below for thread from co-first @constantine_sci; lovely collab with @liverquant @drjessicashay @ohyilmaz @wgoessling

[UPMC Hillman Cancer Center @UPMCHillmanCC]

UPMC Hillman Director @RobertFerrisMD gives the State of the Cancer Center Address to kick off the 35th Annual Scientific Retreat!

[Fabian Theis @fabian_theis]

Excited that veloVI is out @naturemethods! Led by @adamgayoso & @PhilippWeiler7 w awesome @YosefLab, we combine deep generative modeling with a mechanistic single-cell transcriptional model for better RNA velocity analysis with uncertainty quantification. https://t.co/EaBpcqwexi

[Science Immunology @SciImmunology]

New research from @Vignali_Lab involving human data identifies a tumor-specific population of immunosuppressive regulatory T cells dependent on BATF and associated with poorer outcomes for head and neck squamous cell carcinomas. @PittTweet

📄: https://t.co/qm5Fvls0q0

[Vignali Lab @Vignali_Lab]

Regulatory T cells are phenotypically and functionally heterogenous in the TME, but what are the transcriptional networks of functionally suppressive Tregs in the TME?

Our latest work from the lab and first-author @Feng_Shan_ is out now at @SciImmunology! https://t.co/VipvrWy6Q2

[Science Immunology @SciImmunology]

Two new studies present insights into regulatory T cells located in tumors associated with head and neck squamous cell carcinomas and non-small cell #LungCancer.

By @Vignali_Lab: https://t.co/9NvZsHcapW
By @SmithImmunology: https://t.co/quwGFQoy3N

[Katherine Aird @airdlab]

BIG NEWS! Hillman Cancer Center at the University of Pittsburgh now has an Oncology Graduate Program. Applications will open in September.

[Vignali Lab @Vignali_Lab]

Amazing collaborative effort and an honor (and fun) to work with @oesterreichs! And kudos to @OnkarSayali