Puri Fortes

Scientist fascinated by how noncoding RNAs impact biomedicine. Energy from family&friends. Love #noncodingRNA, believe in #RNAtherapy, live in @CIMA_unav

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[Marta Montes @MartaMontes3]

What a nice place for the #Ribored2026!

[Puri Fortes @FortesLab]

Super nice! Congrats!!!

[F. Moreno-Herrero @FMorenoHerrero]

Our latest work is out in Nucleic Acids Research @OxfordJournals We introduce Optical Tweezers Curtains: a method to study interactions between proteins and DNA-ends at the single-molecule level. @CNB_CSIC @SDeBraganca https://t.co/RyxkYoFynD

[Puri Fortes @FortesLab]

Amazing talk and incredible visit today from @AgamiLab. RNA translation is full of surprises!!! Million thanks Reuven!

[Cima Universidad de Navarra @CIMA_unav]

Today we welcome Dr. Reuven Agami (@NKI_nl), who will present: “When Mistranslation Meets Immunotherapy” organized by @FortesLab and @MaiteHuarteLab
A leading expert in #oncogenomics, his work has pioneered genetic tools to uncover how gene regulation drives #cancer.

[The Aptamer Society @AptamerSociety]

#AptOx26 starting tomorrow - 23rd March - at St Edmund Hall, #Oxford. Vew agenda here:

https://t.co/h7RmRUykRS

[Apadrina la Ciencia @ApadrinaCiencia]

📢 Los fondos son limitados. Ayúdanos a que #científicas en países de desarrollo tengan los recursos que merecen. ¡Cualquier aporte hasta 50€ se multiplica!!
👉¡Dona aquí!
https://t.co/78I98WHDaq

[Puri Fortes @FortesLab]

Super nice story! Do not miss this! I am still amazed about how a small protein extension can turn PTMA protein into more oncogenic! It is great to collaborate with the great Mar Alba lab! Mar… will there be a third preprint this month? 😳

[Mar Albà @maralbasoler]

Second preprint of the month!

Analysis of stop-loss mutations in > 20,000 cancer samples shows that several oncogenes and tumor suppressor genes are recurrently mutated. Another fruitful collaboration with @FortesLab @GRIB_Barcelona

https://t.co/vEDdyc98M3

[Mar Albà @maralbasoler]

New preprint from the group!

Here we use Nanopore dRNA and Ribo-Seq data from multiple yeast species to discover tens of highly conserved microproteins encoded by uORFs in polycistronic transcripts/alternative isoforms. @the_prbb

https://t.co/Z0pKqBYaCa

[Cima Universidad de Navarra @CIMA_unav]

"Zorevunersen es el primer tratamiento diseñado para actuar específicamente sobre la causa de #Dravet". Nuestro científico Rubén Hernández comenta en
@elmundosalud los resultados de un estudio internacional publicado en @NEJM
📰 Un reportaje de @cglucio
https://t.co/YmesI08MWf

[nature @Nature]

Nature research paper: GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling

https://t.co/dJ7FVVlavU

[Molecular Cell @MolecularCell]

Online Now: Why m⁶A? An RNA surveillance model https://t.co/nLEQK2xtBU

[Puri Fortes @FortesLab]

Congrats!!! Even mooore work!

[Igor Ulitsky @IgorUlitsky]

Busy times ahead. I apologize in advance for potentially taking longer to respond to e-mails for a few years...

[Christine Mayr @Mayr_Christine]

More than 2700 3′UTRs are highly conserved.

These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance.

Highly conserved 3′UTRs help the folding of proteins with long IDRs.

https://t.co/b6hd4AlIoX

[Puri Fortes @FortesLab]

Super nice! Congrats

[Marta Montes @MartaMontes3]

Very happy to share our work in collaboration with @MaiteHuarteLab @ElenaGrossi8 @CIMA_unav. Congratulations to all the people involved. It's been a long journey! https://t.co/KUcqEoiGB6

[Puri Fortes @FortesLab]

Las terapias de RNA… nos pueden llevar hasta el infinito y mas alla!

[CaixaResearch @CaixaResearch]

1/ El ARN nos abrió la puerta a las vacunas contra la COVID-19 en tiempo récord.💉

Las terapias de ARN prometen transformar la medicina, pero… ¿Hasta dónde nos pueden llevar?🤔

4️⃣ investigadores de la red #CaixaResearch nos lo explican:👇

https://t.co/V5GxhanWae

[Molecular Cell @MolecularCell]

Prkra dimer senses double-stranded RNAs to dictate global translation efficiency https://t.co/RVnexg3dOi

[Puri Fortes @FortesLab]

Wow!!! Maite! Seguro que les dejas super impresionados! Congrats!!!

[Maite Huarte @MaiteHuarteLab]

Muy contenta de tener la oportunidad de hablar sobre RNAs reguladores en la Real Academia de Ciencias👇

[Kevin Hall @KevinH_PhD]

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology. Lately, I’ve focused on unravelling the reasons why diets high in ultra-processed food are linked to epidemic proportions of chronic diseases such as diabetes and obesity. Our research leads the world on this topic.

Given recent bipartisan goals to prevent diet-related chronic diseases, and new agency leadership professing to prioritize scientific investigation of ultra-processed foods, I had hoped to expand our research program with ambitious plans to more rapidly and efficiently determine how our food is likely making Americans chronically sick.

Unfortunately, recent events have made me question whether NIH continues to be a place where I can freely conduct unbiased science. Specifically, I experienced censorship in the reporting of our research because of agency concerns that it did not appear to fully support preconceived narratives of my agency’s leadership about ultra-processed food addiction.

I was hoping this was an aberration. So, weeks ago I wrote to my agency’s leadership expressing my concerns and requested time to discuss these issues, but I never received a response. Without any reassurance there wouldn’t be continued censorship or meddling in our research, I felt compelled to accept early retirement to preserve health insurance for my family. (Resigning later in protest of any future meddling or censorship would result in losing that benefit.) Due to very tight deadlines to make this decision, I don’t yet have plans for my future career.

The NIH has been a wonderful place because it allows scientists to take risks, form unique collaborations, and do studies difficult to conduct elsewhere. I’m proud of what we’ve accomplished and I’m fortunate to have had such wonderful colleagues and scientific collaborators. I hope to someday return to government service and lead a research program that will continue to provide gold-standard science to make Americans healthy.

[Puri Fortes @FortesLab]

Amazing supervisor 👍

[Josepmaria Argemi @jargemib]

Seeking MSCA Postdoctoral Fellow Candidate - Stress response and immunotherapy https://t.co/7KwRUi3zyD

[Igor Ulitsky @IgorUlitsky]

Don't think I've ever met scientists as terrified/depressed as I've seen in the US this week (and I live in a war zone).