Scientist fascinated by how noncoding RNAs impact biomedicine. Energy from family&friends. Love #noncodingRNA, believe in #RNAtherapy, live in @CIMA_unav
Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)
https://t.co/SbshGhofN0
Our latest work is out in Nucleic Acids Research @OxfordJournals We introduce Optical Tweezers Curtains: a method to study interactions between proteins and DNA-ends at the single-molecule level. @CNB_CSIC@SDeBraganca https://t.co/RyxkYoFynD
Today we welcome Dr. Reuven Agami (@NKI_nl), who will present: “When Mistranslation Meets Immunotherapy” organized by @FortesLab and @MaiteHuarteLab
A leading expert in #oncogenomics, his work has pioneered genetic tools to uncover how gene regulation drives #cancer.
📢 Los fondos son limitados. Ayúdanos a que #científicas en países de desarrollo tengan los recursos que merecen. ¡Cualquier aporte hasta 50€ se multiplica!!
👉¡Dona aquí!
https://t.co/78I98WHDaq
Super nice story! Do not miss this! I am still amazed about how a small protein extension can turn PTMA protein into more oncogenic! It is great to collaborate with the great Mar Alba lab! Mar… will there be a third preprint this month? 😳
Second preprint of the month!
Analysis of stop-loss mutations in > 20,000 cancer samples shows that several oncogenes and tumor suppressor genes are recurrently mutated. Another fruitful collaboration with @FortesLab@GRIB_Barcelona
https://t.co/vEDdyc98M3
New preprint from the group!
Here we use Nanopore dRNA and Ribo-Seq data from multiple yeast species to discover tens of highly conserved microproteins encoded by uORFs in polycistronic transcripts/alternative isoforms. @the_prbb
https://t.co/Z0pKqBYaCa
"Zorevunersen es el primer tratamiento diseñado para actuar específicamente sobre la causa de #Dravet". Nuestro científico Rubén Hernández comenta en
@elmundosalud los resultados de un estudio internacional publicado en @NEJM
📰 Un reportaje de @cglucio
https://t.co/YmesI08MWf
More than 2700 3′UTRs are highly conserved.
These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance.
Highly conserved 3′UTRs help the folding of proteins with long IDRs.
https://t.co/b6hd4AlIoX
Very happy to share our work in collaboration with @MaiteHuarteLab@ElenaGrossi8@CIMA_unav. Congratulations to all the people involved. It's been a long journey! https://t.co/KUcqEoiGB6
1/ El ARN nos abrió la puerta a las vacunas contra la COVID-19 en tiempo récord.💉
Las terapias de ARN prometen transformar la medicina, pero… ¿Hasta dónde nos pueden llevar?🤔
4️⃣ investigadores de la red #CaixaResearch nos lo explican:👇
https://t.co/V5GxhanWae
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology. Lately, I’ve focused on unravelling the reasons why diets high in ultra-processed food are linked to epidemic proportions of chronic diseases such as diabetes and obesity. Our research leads the world on this topic.
Given recent bipartisan goals to prevent diet-related chronic diseases, and new agency leadership professing to prioritize scientific investigation of ultra-processed foods, I had hoped to expand our research program with ambitious plans to more rapidly and efficiently determine how our food is likely making Americans chronically sick.
Unfortunately, recent events have made me question whether NIH continues to be a place where I can freely conduct unbiased science. Specifically, I experienced censorship in the reporting of our research because of agency concerns that it did not appear to fully support preconceived narratives of my agency’s leadership about ultra-processed food addiction.
I was hoping this was an aberration. So, weeks ago I wrote to my agency’s leadership expressing my concerns and requested time to discuss these issues, but I never received a response. Without any reassurance there wouldn’t be continued censorship or meddling in our research, I felt compelled to accept early retirement to preserve health insurance for my family. (Resigning later in protest of any future meddling or censorship would result in losing that benefit.) Due to very tight deadlines to make this decision, I don’t yet have plans for my future career.
The NIH has been a wonderful place because it allows scientists to take risks, form unique collaborations, and do studies difficult to conduct elsewhere. I’m proud of what we’ve accomplished and I’m fortunate to have had such wonderful colleagues and scientific collaborators. I hope to someday return to government service and lead a research program that will continue to provide gold-standard science to make Americans healthy.