❗️Excited to share my PhD work in Genome Biology: PRODE recovers essential and context-essential genes through neighborhood-informed scores.
What is PRODE, and how does it help?👇
Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: https://t.co/zmECC5yxRS. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!
🚨 New Preprint Alert! 🚨
I’m thrilled to share our latest study now online on JCI: CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer.
🔬 Check out the preprint here: https://t.co/Svr0nSY1CF
Huge thanks to @FrancescaBZNY, @FraLo05, all Demichelis’ lab members and facilities staff at @UniTrento@CIBIO_UniTrento, and key collaborators @quimmateo, @FdAdF66 and Helmut Klocker.
Special thanks to Fondazione Trentina per la Ricerca sui Tumori, @AIRC_it fellowship, @ERC_Research, @PCF_Science, and MIUR.
#ProstateCancer #CRPC #LIG1 #PARPi #Biomarker #SyntheticLethality #PrecisionMedicine
Interested in the interplay between human #genetics and the #microbiome ? Nice opportunity for a #PhD position in my lab at @CIBIO_UniTrento in collaboration with @asnicar and @nsegata at @cibiocm Check for scholarship 1C here: https://t.co/rz8ht0kQGN deadline 17th June
CIBIO is hosting Titia De Lange from @RockefellerUniv winner of the 2024 @pezcoller@aacr Award for the Pezcoller Lecture:
Telomeres and #Cancer: Tumor Suppression and Genome Instability
🗓️ May 10th, 2.30 p.m.
🏦 Sala Stringa, FBK
ℹ️ https://t.co/gi4GaXrirm
#CIBIO
The department has launched a call to fill a tenure-track assistant professor position in molecular biology (RTT, BIO/11). Send your applications in!
📅 May 16th, 12.00
➡️ Apply here: https://t.co/JEs4d1FYW6
#ScienceJobs#research
A couple of years ago Andi @villunger and I suspected that extra centrosomes kill blood cells via Caspase-2. Problem was: ko of candidate substrates had no phenotype. Now @dario_rizz and @VincenzaVigo figured out why https://t.co/hvEhbQbpf7
Surprising mechanism revealed by androgen-independent PSA spikes in chronic prostate inflammation:
EV-delivered TRPM8 mRNA promotes TLR3 & NF-kB signaling, and antitumorigenic sterile inflammation
@AlessandroAlai7 @LunardiLabCIBIO et al @CIBIO_UniTrento
https://t.co/htHHD29u7O
ANNOUNCEMENT: RFA for 2024 @PCFnews Young Investigator Award Applications, to support innovative & highly promising early career #ProstateCancer researchers.
DEADLINE: 4/15/24
Application Portal opens 1/29/24
https://t.co/dlTP0futsZ
View the RFA here: https://t.co/bNnRQrLIJQ
I am beyond excited to see our work out in @CD_AACR . We established a targeted sequencing assay to non-invasively monitor treatment resistance in advanced prostate cancer. Want to know more? Let’s take a short walk 👣
https://t.co/zKlDZe0Dsh