The Frock Lab

We discover new DNA connections to understand how to improve health.

[The Frock Lab @FrockLab]

Postdoctoral Scholar position open for the Frock lab! Please repost.

[Stanford Radiation Oncology @StanfordRadOnc]

Elucidating the line of succession for a predominant DNA repair pathway to tackle cancer’s adapted DNA repair abilities: @RichardFrock 's new paper published in @ScienceAdvances! #oncology #Cancercare #genomics #cancerbiology #stanford
https://t.co/rLEywJo5eo

[The Frock Lab @FrockLab]

Really excited to share this work led by Jinglong Wang. It's an in-depth look at end joining that reveals additional insights into repair hierarchy and V(D)J recombination. Many thanks to the thoughtful reviewers, @ScienceAdvances, @AmericanCancer, and @TheVFoundation.

[The Frock Lab @FrockLab]

Eliminating core NHEJ factors reveals two distinct alternative end joining mechanisms. We investigate how one of them collaborates with the DDR to suppress MMEJ. https://t.co/G9cX4GYtNA

[The Frock Lab @FrockLab]

In this work, we find the PARP1-XRCC1/Lig3 axis, in collaboration with ATM, suppresses MMEJ. Inhibiting DDR components promotes genome-wide translocations while eliminating 53BP1 severely limits repair capacity of this alternative end joining pathway.

[Nick Pannunzio @pannunziolab]

Excited to announce our latest paper in @NatureComms, led by amazing PhD student @ValeriaRangelPL, as part of our ongoing effort to address Latin American cancer health disparities in acute lymphoblastic leukemia https://t.co/vrT9wIyx76 🩸🧬👩‍🔬

[UC Irvine School of Medicine @UCIMedSchool]

#UCIMedSchool researchers from the @PannunzioLab have identified a key enzyme contributing to #cancer health disparities within the Latin American population. https://t.co/6NdNoTAL1F #UCIrvine

[Zha Lab @zha_lab]

Thank Dr. Armache @KJArmache for a nice talk. Three rising stars will share their science on Social DNAing - Drs. Pratto @FlorenciaPratto, Frock @RichardFrock , and Leuzzi @GiuseppeLeuzzi_ . Don't miss the future. Sign up at https://t.co/XaGM9Lt62q

[National Academy of Sciences @theNASciences]

Congratulations Andre Nussenzweig of @NCIResearchCtr, newly inducted #NASmember! #NAS161 #genomics #cancerresearch

[Chetan Rawal @Chetan109Rawal]

Exciting work by Cavalli lab lead by Victoria and Vincent! Happy to be a part of this wonderful collaboration between Cavalli lab and @chiolo_lab ! Heartiest congratulations to all the team!

[The Frock Lab @FrockLab]

Ever wonder how the DDR handles alternative end joining? Check out the latest in preprint form from the Frock Lab! https://t.co/gPqcpI9BlY

[The Frock Lab @FrockLab]

Breaking News! Partial DNA-PKcs inhibition promotes translocations via NHEJ while complete inhibition promotes the transition to using more MMEJ. See Jinglong Wang's study from the FrockLab below: https://t.co/TdCLcaBgQj

[The Frock Lab @FrockLab]

Ringing in the New Year with a preprint Led by Jinglong Wang from the FrockLab: DNA-PKcs Suppresses Illegitimate Chromosome Rearrangements
https://t.co/FcJpj5xk7K

[Steven Artandi, MD, PhD @SCIDirector]

We are searching for an expert in DNA repair and DNA damage responses to join our team as an Assistant or Associate Professor and develop a robust research program in this area. Learn more and apply: https://t.co/wxpZnrg3IN #cancerresearch #clinicaltrials

[Richard Frock @RichardFrock]

Checkout our FLASH-RT paper on chromosome translocations free for the next month! Thanks to @elsevier for helping to share the knowledge! #FLASH https://t.co/F4g49FkWoe

[The Frock Lab @FrockLab]

Excellent work by our team and collaborators demonstrating similar translocation patterns between FLASH and Conventional RT! @VozeninC @BLoo_LT_SABR @LimoliCharles #FLASH https://t.co/3uLmlSDUiw

[Stanford Radiation Oncology @StanfordRadOnc]

Training Opportunity: @StanfordRadOnc Diversity Postdoctoral Fellowship Program is now taking applications.

Deadline: June 2, 2023

[American Cancer Society @AmericanCancer]

The American Cancer Society is awarding 90 new Research and Career Development Grants totaling $45M, funding researchers at 67 institutions nationwide. These grantees are leading innovative discoveries that advance our mission to end cancer, for everyone. https://t.co/aCSLNkNykc

[The Frock Lab @FrockLab]

Hot off the preprint press for the FrockLab: Chromosome translocations are undistinguished between FLASH-RT vs. CONV-RT across various oxygen tension ranges. https://t.co/ByaEJdPjAZ

[The Frock Lab @FrockLab]

Check out our review that came out recently!
DNA End Joining: G0-ing to the Core https://t.co/iuGbwRFPdf #mdpibiomolecules via @Biomol_MDPI