George Thornton

Interventional imaging/Research Fellow @Cedars Sinai Medical Center, Clinical Lecturer @UCL, Chief Medical Officer @MycardiumAI Core Lab.

[Charlotte Manisty @dr_manisty]

Heart function stayed stable at 1 year after carefully monitored withdrawal of heart failure therapy in breast cancer survivors with recovered anti-HER2 cardiotoxicity. Work from our group at @ucl, presented by @bmdwsg as a Late-Breaking Trial at #ESCCongress 2026 & published simultaneously in @ehj_ed: HER-SAFE. @TheBHF @escardio @MycardiumAI #CardioOnc
🔗 https://t.co/pZ2m3aRnIp

[George Thornton @GD_Thornton]

With thanks 🙏🏼 to my coauthors, collaborators, funders and, above all, to the patients who gave up their time to support this work.

[George Thornton @GD_Thornton]

Our study in @JAMACardio: 72 patients with severe AR, paired CMR, echo and CPET before and 7 months after AVR. LV volume fell 44% and mass 21%, but scar was associated with less remodelling and peak VO2 unchanged. @UCL_ICS @TheBHF @NHSBartsHealth
https://t.co/MilRzgNl8J

[Thomas Treibel @ThomasTreibel]

Excited to see our work on myocardial fibrosis and reverse remodelling after AVR for chronic aortic regurgitation published in @JAMACardio! https://t.co/8TwXiyKces
At 7 months post AVR:
🔹 LVEDV ↓44%
🔹 LV mass ↓21%
🔹 Matrix ↓15%
But focal scar did not regress #whyCMR @TheBHF

[Ruey Hu, MD, MPH @ruey_hu]

How do you handle persistently low dock position during #TMVR with the #M3 system?

If usual maneuvers fail, 2nd transseptal puncture can be considered for double guide sheath technique. Here's what we learned @CedarsCards @RajMakkarMD, out in @JACCJournals Interventions. 👇

[Ignacio J. Amat @ignamatsant]

🫀 First-in-human valve-in-valve TAVI in mechanical prostheses
Bench-to-bedside study: disc dislodgement & retrieval followed by successful TAVI.
Published in European Heart Journal.
👉 https://t.co/tORjwdmhy6

@escardio @PCRonline @secardiologia @CNIC_CARDIO @sacyl @TCTMD

[Aakriti Gupta, MD MSc @aakriti_15]

So proud of @ShubhaPawar for leading this cross-disciplinary collaboration that distills today’s best evidence in aortic regurgitation (diagnosis and treatment), now in @JACCJournals. IM residencies: @ShubhaPawar is applying this season - take note. @CedarsSinai @CedarsSinaiMed https://t.co/YOouwZp1LB

[Christopher Rajkumar @rajkumar_chris]

Ever wondered why some pts feel every balloon inflation, while others feel nothing? 💭

Or why severe ischemia can be asymptomatic?

Our placebo-controlled, n-of-1 study — simultaneous in #Circulation & #TCT2025 — shows collateralization may be key.

🔗 https://t.co/uyAw3gXAx3

[George Thornton @GD_Thornton]

@drjohnm @divaka_perera On a background of OMT*

[George Thornton @GD_Thornton]

@drjohnm @divaka_perera Agree entirely that we shouldn’t be doing PCI in these patients, but important to note that REVIVED doesn’t show PCI doesn’t work, it shows PCI doesn’t improve prognosis compared with optimal medical therapy

[John Mandrola, MD @drjohnm]

https://t.co/QHLboxkGpQ Highest congratulations to the authors, Dr. Signe Glargaard et al

[Ash Paul @pash22]

KOLs boost Early Aortic Valve Intervention in Patients with Asymptomatic AS--Despite Dubious Evidence:
@JAMACardiology featured a strong editorial urging cardiologists to intervene early in patients who have aortic valve stenosis and no symptoms. I do not agree via @drjohnm
https://t.co/bMt8Gl1SwU @gbiondizoccai @Coronary4front @cpgale3

[Christopher Rajkumar @rajkumar_chris]

Should PCI be an option for first line management of stable angina symptoms?

Point and counterpoint in @CircOutcomes with final word from @bnallamo and @TCTMD

https://t.co/501Y7HHgKB

@rallamee

[George Thornton @GD_Thornton]

@fiyyazAJ @rajkumar_chris @rallamee @mshunshin @MikeFoley89 @ShaynaChotai @FloSimader @ProfDFrancis 🎉🎉🎉🎉🎉🎉🎉

[Rasha Al-Lamee @rallamee]

Now I’m officially bursting with pride!

[Michael Foley @MikeFoley89]

The symptom stratified analysis of ORBITA2 and the ORBITA-STAR trial both presented at #EuroPCR2024 and simultaneously published in @JACCJournals by @FloSimader and @rajkumar_chris. PCI isn’t a therapy for all symptoms, it’s a therapy for angina @rallamee @mshunshin

[JACC Journals @JACCJournals]

.@FloSimader on #ORBITA-2 at #EuroPCR:
📌Poor correlation between symptoms & disease severity
📌Symptom nature is a powerful predictor of the placebo-controlled efficacy of #PCI
📌Rose angina & typical angina are excellent predictors of the placebo-controlled efficacy of PCI
📌Other symptoms such as SOB are poor predictors of the placebo-controlled efficacy of PCI

[Anil Makam @AnilMakam]

In contention for BEST study of the year thus far

N of 1 trial of patient-blinded occlusion of target vessel

The more angina was inducible, the more symptom relief after PCI

Best 2 figures

Now, how best to verify if symptoms truly are angina?

[JACC Journals @JACCJournals]

ICYMI: Watch this insightful video by Drs. @rallamee & @rajkumar_chris where they shed light on their #JACC paper discussing the N-of-1 trial of angina verification before #PCI.

Access the full 📄 here: https://t.co/DSpWm9dLu5

#EuroPCR #ORBITA @hmkyale

[Christopher Rajkumar @rajkumar_chris]

In ORBITA-STAR, angina verification with an ischaemic stimulus powerfully predicted response to PCI. #EuroPCR2024

Perhaps we have been too focused on treatment when the problem always lay in the diagnosis! Published today in #JACC https://t.co/1Yj9mJ6MxS @rallamee