New research from @PDClab @Shawn__Ferguson & colleagues finds that the bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage; #Parkinsons-associated LRRK2, is also recruited but at later stage
https://t.co/ocpPHPY6Mc
LRRK2 is a kinase whose activity is linked to #Parkinsons disease. New research from @abentleydesousa and @shawn__ferguson reveals converging roles of STING and #lysosome damage in activating LRRK2 at #lysosomes via interactions between LRRK2 and GABARAP. https://t.co/D0061KhXJW
Lysosomal TBK1 responds to amino acid availability at the lysosome surface, to promote mTORC1 activation by relieving Rab7-dependent inhibition
Gabriel Talaia @GTalaia, Amanda Bentley-DeSousa @ABentleyDeSousa, Shawn Ferguson @Shawn__Ferguson @YaleCellBio
https://t.co/KBt9rPukd5
Thrilled to see this work finally published @embojournal thanks everyone @ABentleyDeSousa @Shawn__Ferguson @YaleCellBio@YaleNeuro
Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition | The EMBO Journal https://t.co/VUnyQiN21r
New research from @GTalaia@ABentleyDeSousa & @Shawn__Ferguson highlights a role for TANK-binding kinase 1 (TBK1) in lysosome homeostasis (alleviating Rab7-mediated inhibition of mTORC1 activation); May contribute to the pathogenesis of ALS-FTD
https://t.co/ou0JTJ8hma
Critical new insight into a role for TBK1 - an ALS-FTD disease gene - at lysosomes. Congrats to @GTalaia@ABentleyDeSousa from @Shawn__Ferguson lab!
https://t.co/jl7yKw3B14
Lipid transfer from the ER by Vps13 proteins is a key part of the cellular response to lysosome damage - see new work from @PDClab in collab with @Shawn__Ferguson:
https://t.co/3cuPa7khev
Check out our 'First persons' interview with Cláudia Barata-Antunes and Gabriel Talaia @GTalaia on their joint project @UMinho_Oficial investigating trafficking of the en1 carboxylate transporter: https://t.co/97pjlQoiXJ
What a great experience to publish in @J_Cell_Sci. If you are interested check out the final version of the manuscript and a first author interview. https://t.co/YQQTQTEzQ8
https://t.co/kHghZh44ao