Ari Gattu

Endocrinologist @ MGH@Joslin; Glucose, lipids, hormones, and running. Thoughts are my own.

[Antelm Pujol, MD PhD @AntelmPujol]

💊 ¿Es obligatorio tomar la levotiroxina en ayunas?

Clásicamente sí. Pero un nuevo RCT en JCEM (2026) plantea algo interesante que puede cambiar la práctica clínica 👇

[Veera Rajagopal  @doctorveera]

Exome sequencing and analysis of 44k South Asians from the Genes & Health cohort (G&H) now published in Nature Genetics.

Of all the South Asian centric cohorts, G&H is my favorite. They have been doing high quality work and sharing the results generously to everyone in the field.

G&H is dedicated exclusively for British South Asians of Pakistani and Bangaldeshi heritage. In the current work, the authors studied whole exome sequencing (WES) of 44,028 individuals.

The value of such cohorts become immediately evidenct when you contrast with existing large European-based cohorts/databases such as UK Biobank, gnomAD. Some interesting stats reported in this paper:

- 26% of G&H coding variants are completely absent in gnomAD (this rises to ~50% when compared only with the European subset of gnomAD)
- 33% offspring of consanguineous marriages (vs 2% in the UKB)
- consequently, 1.8% of average genome is in runs of homozygosity (ROH) (vs 0.4% in UKB)
- this high autozygosity yields 2.4x more homozygous genotypes than what you'd expect under random mating
- for ~3k genes at least one homozygous (or comp het) pLOF carrier ('knockouts') was found, of which 1,669 are seen in only G&H despite being 10x smaller than UK Biobank.
For 546 genes, knockouts are seen only in G&H when compared to even 5 major larger biobanks combined (~1.4 million)

Great work and an incredible progress in South Asian genetics, again, unsurprisingly from a South Asian cohort built outside South Asia

Congrats to G&H team!

Kim et al. Nat Gen 2026
https://t.co/bwrwFZeOKd

[Jeffrey Flier @jflier]

Explore this gift article from The New York Times. You can read it for free without a subscription. https://t.co/VIORNnKy34

[Ari Gattu @GattuAri]

@doctorveera Much needed work. Looking forward to seeing great work ahead. Congratulations and good luck !!@doctorveera

[Ari Gattu @GattuAri]

Much needed discussion. It’s a masterclass on aldosterone in hypertension. @AnandVaidya17 @thecurbsiders

[Anand Vaidya @AnandVaidya17]

A PRIMARY ALDOSTERONISM PODCAST
Appreciate the Curbsiders team for letting me join their amazing platform to share the message: “essential hypertension is primarily aldosteronism”.

Including some helpful resources in the thread below

https://t.co/yNnZPDkFe6

[Ari Gattu @GattuAri]

@Teensthack @ratnabhushanET That’s fascinating!! Thanks for sharing.

[Pradeep Natarajan @pnatarajanmd]

South Asian individuals have greater CVD event rates and comprise 1 in 4 individuals worldwide. However, in our systematic review of 310 major CVD trials led by @NishantUppal7, only 3% of trial participants are South Asian individuals https://t.co/K6U8dkj6Ls @JACCJournals #JACCAsia @AniruddhPatelMD @DLBHATTMD

[MASALA Study @masala_study]

Need more South Asian individuals to join research studies…

Dismal representation in trials (3%) and even worse in genetic studies (1%)

Hard to believe these lousy stats because SA represent 23% (1.8B) people in the world

[Diabetologia @DiabetologiaJnl]

Non-autoimmune diabetes in undernourished young people in NE India reveals intricacies of diabetes phenotypes in rapidly transiting populations. Rural lean people show reduced insulin secretion; urbanised overweight people show insulin resistance https://t.co/FlXRkIN5k3

[Jeff Schwimmer @TheLiverPost]

📢 New in @jclinicalinvest : We explore pediatric MASLD as a distinct, early-onset liver disease shaped by perinatal factors, genetics, and hepatic zonation.
@SudhaBiddinger @SamarHIbrahimMD
Opportunities for early intervention start in childhood.
🔗https://t.co/ki2ZUJfBTn

[Cell Metabolism @Cell_Metabolism]

Testing the carbohydrate-insulin model: The data are supportive! https://t.co/BMXknnChDl

[Kevin Hall @KevinH_PhD]

Really enjoyed Max Petersen’s talk at #NLASessions on the topic of hypothetical mechanisms of increased LDL cholesterol and ApoB with ketogenic diets. Looking forward to his forthcoming data measuring metabolic fluxes! https://t.co/zk6mrs2wLn

[Ankur Kalra @AnkurKalraMD]

The @timesofindia has given the documentary-drama, The Brown Heart, 4.5/5 stars. Please help us spread the word, share your feedback, and catch the review here: https://t.co/s5P3KUwpoG

[Pradeep Natarajan @pnatarajanmd]

Honored to contribute to the @ASPCardio Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by @dranandrohatgi @DrMarthaGulati @jaideeppatelmd https://t.co/O5cmGg8DHX @AJPCardio

[Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 @DrMarthaGulati]

Our @ASPCardio statement on South Asians & Cardiometabolic Health in @AJPCardio
I had the honour of co-chairing this w/ the amazing @dranandrohatgi & @jaideeppatelmd
Thank you to our entire talented team who brought this to life
📎https://t.co/37h63IGszU
#CVPrev #CardioTwitter

[Ari Gattu @GattuAri]

@jclinicalinvest .We have uncovered "impaired" and "emergent" insulin signaling defects in T2D liver. Is "emergent" signaling the basis of "selective insulin resistance"? Thank you, Kahn, @labs_mann, Cantley labs. https://t.co/aCgEYssa13

[Rashmi @rashmibp]

we found significant parental effects on cardiometabolic traits from birth through puberty to early adulthood. read more here

[Diabetologia @DiabetologiaJnl]

Parent-of-origin effects in the life-course evolution of cardiometabolic traits https://t.co/45mSh63a6n 🔓

[NEJM @NEJM]

A reversible interaction between bempedoic acid and fenofibrate leading to a major, reversible decrease in HDL cholesterol levels was found in patients treated for nongenetic elevated LDL cholesterol levels. Learn more: https://t.co/8L4mLxC1nM