Marsel Lino

Postdoctoral Fellow @Harvard, @HarvardMed, @JoslinDiabetes, studying diabetes and adipose tissue biology.

[Marsel Lino @m_lin0]

Looking forward to this year’s @AmDiabetesAssn #ADA2025 #ADASciSessions! I’ll be giving a talk on metabolic regulation by brown fat miRNAs, hope to see you there!

[Marsel Lino @m_lin0]

@DarioFDeJesus @JoslinDiabetes @UChicagoMed That’s awesome Dario, congratulations!

[Marcelo A. Mori @MoriLabe]

Cool paper from the Treebak lab showing how DICER is quickly downregulated in adipose tissue upon diet-induced obesity and in humans with obesity, representing a hallmark of metabolic dysfunction

[University of Toronto @UofT]

TODAY at 6 PM ET – Join us virtually for a press conference with #UofT Professor Emeritus Geoffrey Hinton, laureate of the 2024 @NobelPrize in Physics.🎥

Watch live: https://t.co/JUfOxynaGV

[MassGeneral News @MassGeneralNews]

Mass General and @harvardmed Investigator Gary Ruvkun, PhD, has won the 2024 @NobelPrize in Physiology or Medicine. He is honored for his discovery of small regulatory RNAs. Congratulations! Learn more: https://t.co/vpErhP8BA4

[Alexander Bartelt @BarteltLab]

A cold-regulated switch allows thermogenesis in brown fat mitochondria - here our @LMU_Muenchen @LMU_Uniklinikum press release!
👇
https://t.co/CZYUmGaH5F

[Alexander Bartelt @BarteltLab]

Out now in The EMBO Journal:

Uncoupling is important for brown fat but is coupled respiration regulated, too?

We found that IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis
👇
https://t.co/Cq1tSA2TNP

[Marsel Lino @m_lin0]

Excellent work by @FerrazBannitzR and co-authors from the Patti lab @JoslinDiabetes published in @jclinicalinvest! 👇🏻

[Rafael Ferraz Bannitz @FerrazBannitzR]

I'm thrilled to share with you that our latest research has been published in JCI!

We report that the dynamic regulation of serotonin and other tryptophan-derived metabolites is altered in individuals who develop Post-bariatric hypoglycemia (PBH).
https://t.co/AYBtotv6KX

[Rafael Ferraz Bannitz @FerrazBannitzR]

I'm thrilled to share with you that our latest research has been published in JCI!

We report that the dynamic regulation of serotonin and other tryptophan-derived metabolites is altered in individuals who develop Post-bariatric hypoglycemia (PBH).
https://t.co/AYBtotv6KX

[Marsel Lino @m_lin0]

Great to see this paper out @Cell_Metabolism. Amazing work by @DarioFDeJesus, Ling Xiao, and the rest of the team.

[Cell Metabolism @Cell_Metabolism]

New! Online now: m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1 https://t.co/rfUDSgqLzT

[Daniel J Drucker @DanielJDrucker]

They were intended to treat #diabetes The other benefits of GLP-1 medicines were first discovered in preclinical research and later confirmed in clinical trials. Fixed it for you @TheEconomist

[Marsel Lino @m_lin0]

Amazing story, especially if you need a reminder to not give up on your projects/dreams, and to always try to separate facts from opinions.

[Jeffrey Flier @jflier]

My story of GLP1 development being abandoned in early 90’s due to mistaken decisions by a biotech startup and its pharma partner @pfizer is now up @statnews. Drug development is hard, and even the biggest blockbusters can be prematurely abandoned.

[Jeffrey Flier @jflier]

My story of GLP1 development being abandoned in early 90’s due to mistaken decisions by a biotech startup and its pharma partner @pfizer is now up @statnews. Drug development is hard, and even the biggest blockbusters can be prematurely abandoned.

[Yu-Hua Tseng @tsengyuhua]

The endothelin system is traditionally known for regulating vasoconstriction/dilation. Our new paper in @NatureComms shows EDN3-EDNRB induces the browning of human white adipocytes via cAMP-EPAC1-ERK activation. https://t.co/rPCCk21fmS @ChihHaoWang1, Tadataka Tsuji, @FarnazShamsi

[Marsel Lino @m_lin0]

Thanks @TheEndoSociety and @AaronLohr for highlighting our work in brown fat miRNAs!

[Endocrine Society @TheEndoSociety]

#BrownFat and Metabolic Function | Listen to @m_lin0, discuss his #ENDO2024 presentation, “A New Layer of Endocrine Regulation: Brown Fat Secretes Exosomal MicroRNAs, which Regulate Metabolic Functions and Distal Organs,” in this @Endocrine_News Podcast episode: https://t.co/AEhkXRKTob

[Marsel Lino @m_lin0]

@KRothPhD @uiowabiology Congratulations, well deserved!

[Yu-Hua Tseng @tsengyuhua]

Thrilled to share our new paper in @NatureComms! 🌟 Adipocytes can directly sense light via photoreceptors, unveiling a novel adipose-hypothalamus crosstalk through histidine. Read here: https://t.co/XRzdaNYuov #Science #Research #Metabolism

[Marsel Lino @m_lin0]

@mrndhntr @CellReports Thanks Miranda!

[Marsel Lino @m_lin0]

Online now @CellReports! Insulin regulates microRNA sorting/secretion into small extracellular vesicles in adipocytes, which go on to regulate insulin action in hepatocytes, implicating adipocyte-derived microRNAs as endocrine regulators.

[Cell Reports @CellReports]

Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin https://t.co/uudY2aPJOv

[Marsel Lino @m_lin0]

@MarkCBlaser @CellReports Thanks Mark!