Gene Lay Institute of Immunology & Inflammation

Immunology-focused research in cancer & aging | Understanding immune evasion & resilience to improve health outcomes
@BrighamWomens @MassGeneralNews @HarvardMed

[Gene Lay Institute of Immunology & Inflammation @GeneLayInst]

The Gene Lay Institute of Immunology and Inflammation was founded on a generous gift @BrighamWomens @MassGeneralNews & @harvardmed.
https://t.co/nLCgW2s8i5

[Minkyoung Lee @MinkyoungLee1]

Yesterday, the inaugural Gene Lay Institute (GLI) retreat was held at Harvard Business School. It was a pleasure to join the gathering of all GLI scientists. @GeneLayInst

[Science Immunology @SciImmunology]

A new Science #Immunology study addresses recent, conflicting findings on the role of #IL17 in #MultipleSclerosis, showing that IL-17A and IL-17 drive disease in EAE mouse model. @KuchrooLab https://t.co/LfCt5xzhPO

[Kuchroo Lab @KuchrooLab]

An adaptive source of IL-17A/F is indispensable for EAE development! And B cell-derived IL-17 induces IL-23 signaling required to convert stem-like Th17 cells to encephalitogenic Th17 cells.
@GeneLayInst @MGBResearchNews @HarvardMed @BroadInstitute https://t.co/x94ee0LAGA

[Waggoner Lab @LabWaggoner]

Review @NatImmunol @QuintanaLabHMS
Astrocyte-driven immunosuppression in the brain tumor microenvironment
https://t.co/mzLBqft3hH

[Waggoner Lab @LabWaggoner]

B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis @SciImmunology
https://t.co/RWEUemQ3go @KuchrooLab @BrighamWomens

[Waggoner Lab @LabWaggoner]

Review @JExpMed @Vignali_Lab @aamirbkbz
@KuchrooLab
Inhibitory receptor agonists: Emerging strategies in immune modulation
https://t.co/UxVJWI7sDn

[Waggoner Lab @LabWaggoner]

Tim-3 restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway @NatureComms @KECKSchool_USC
https://t.co/I4n4w0MqTj

[Journal of Experimental Medicine @JExpMed]

In this review, Adam, Suhail, Kuchroo, and Vignali highlight the challenges and novel approaches to developing agonistic inhibitory receptor (IR)-targeted therapies to treat #autoimmunity and inflammatory disorders.
https://t.co/3dgvwDpume

#CancerFocus #LymphocyteBiology

[Xavier Lab @TheXavierLab]

Excited to share our new study defining the multicellular ecosystem of atopic dermatitis. Integrating >700k single cells from healthy and inflamed skin, we uncover disease-specific immune circuits linked to disrupted keratinocyte differentiation.
https://t.co/PbVfffuLUP

[Xavier Lab @TheXavierLab]

New study, in collaboration with @Honda1Kenya, out now in @Nature. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways.

https://t.co/dGz6e94ak9

[Xavier Lab @TheXavierLab]

Our latest work, with @MikaKivimaki lab, now online @alzdemjournals: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease.

https://t.co/h6VKNJju36

@broadinstitute
@MGHMolBio
@MGBResearchNews

#Alzheimers

[Xavier Lab @TheXavierLab]

New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment.
https://t.co/STBFqkEAB3

@broadinstitute
@MGHMolBio
@MGBResearchNews

[Howard L. Weiner, MD @weinerlabhms]

Jon Zurawski & Rob Bakshi had oral talk at ACTRIMS in San Diego integrating 7T LME and cortical lesions with novel CSF proteomic signatures in MS. Here’s link to Jon's talk: https://t.co/ksFmSkyHf8. We also presented data on proteomic signatures in CSF linked to nasal foralumab.

[Xavier Lab @TheXavierLab]

1/2 New paper out now in Cell Systems @CellPressNews describing development of a deep learning framework to predict allergenic microbial proteases!
https://t.co/n7XPrLb9Er

@broadinstitute @MGHMolBio @MGBResearchNews

[Howard L. Weiner, MD @weinerlabhms]

Was in Saudi Arabia in Dec with Saef Izzy & set up joint projects between the Ann Romney Center & KAIMRC. Projects include nasal anti-CD3 for MS, type 1 diabetes & heat stroke plus probiotics for MS. Here’s link to slides Saef showed in Feb in Riyadh; https://t.co/Lr5RSy2pkc

[Howard L. Weiner, MD @weinerlabhms]

Published new concept of “Progression Independent of the Triggering Event” in Neurology Neuroimmunology & Neuroinflammation - https://t.co/SW1VfDNMu2. Was on cover. Multiple conditions cause CNS damage and trigger common mechanisms that identify common therapeutic approaches.

[Waggoner Lab @LabWaggoner]

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases
https://t.co/Ovr7DE5eN7 @CellGenomics @TheXavierLab @broadinstitute

[Xavier Lab @TheXavierLab]

Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis!

https://t.co/6LMJy1Bxtm

#fibrosis #lung #ILD

[IdoAmitLab @IdoAmitLab]

If you haven’t registered yet, now's the time!
Some of the best minds in neuroimmunology, neuroscience, immunology + AI — in one room.
RTN2026 | Oct 26–28, 2026 | Weizmann Institute
https://t.co/mIiCLbL6yx
@jonykipnis
@QuintanaLabHMS
@stevens1lab
@RejaneRua
@WeizmannScience

[Waggoner Lab @LabWaggoner]

TFR cells are a dynamic and plastic cell subset, the differentiation of which is controlled by intrinsic and extrinsic programs that work together to form a feedback loop to control humoral immunity @NatImmunol @TheSageLab @BrighamWomens
https://t.co/chSgF1KdoP