Emergency med doc trying to grow out curly hair 👩🦱 while doing research to improve emergency neurological care. 🏔Writes haiku sometimes. ❤️ Alt @willmeurer
Thankful to @nih@NIH_NINDS@NINDStrials@UMich and NHLBI (no longer on X it seems) and many others for making this trial possible! @willmeurer - soon we will have a follow up with results.
On the latest episode of "In the Interim…" Dr. Scott Berry and Dr. Will Meurer break down the ICECAP trial design, an innovative, Bayesian, adaptive trial in cardiac arrest research.
ICECAP studies therapeutic hypothermia duration across 10 different cooling periods (6-72 hours) in two patient populations using Bayesian duration-response modeling and response-adaptive randomization. The trial addresses a critical clinical question: how long should we cool patients after cardiac arrest to protect brain function?
Key design features:
✅️ No zero-cooling arm (standard of care made this impossible)
✅️ Weighted mRS outcome measure capturing full recovery spectrum
✅️ Adaptive analyses every 50 patients
✅️ Population-specific allocation for shockable vs. non-shockable rhythms
Results coming soon! This episode covers the design process, the clinical rationale, and the statistical innovation that made ICECAP possible. The results will be a future episode.
Hear about this fascinating design today: https://t.co/4TmJNimfl1
@DrCasteelEM I wouldn’t say crippling - but I definitely needed to get into the right head space before a shift - and didn’t want added stressors. That did fade after 1-2 years (even not being at place I trained.)
@eemoin to miss a smaller effect size. “Clinically significant” on a binary scale of mortality is sort of ridiculous. One can say a 4 mm drop in SBP in a prevention trial is significant because of all the epidemiological work previously done. We actually mean “logistically feasible.”
@eemoin We just say this because we know that showing a reduction in mortality from
20% to 18% requires 12,000 patients and you can’t write “you will only fund a 500 patient study” into a grant. In reality you probably just need to find another study to do if you would be sad … (1/2)
@realzakstuff @harvilla Fortunately we have not had precipitation in a few days and this poor soul was not walking west. Our utterly decrepit roads are excellent at generating puddles. I wouldn’t have hesitated to help his hydration status.
Michigan fans haven't been filled with this much blood lust over the legal system since the last time somebody tried to build affordable housing in their neighborhood
Had an incredible in flight emergency experience on @AmericanAir Yesterday. Patient w LOC & about 30-40 min until landing. Team rapidly assembled (Akeila - an ER Nurse from @BayhealthDE, Eddie a cardiologist from @MaineMed, and Anna the flight attendant) to care for the pt
1/7
Oh you’re going to a teaching hospital in July? Well get ready…
for the most compassionate care from extremely empathetic interns along with their vigilant supervising attendings. Hope you like open ended questions and doctors listening to you bc you’re gonna drown in it.