Gowri Muthukrishnan

Assistant Professor of Orthopaedics, Microbiology & Immunology. Host-microbe interactions. University of Rochester Medical Center @ROC_CMSR @UR_Med @UofR. Dad 2

[Rebecca Keogh @Rebecca_Keogh]

Applications are open for the 2025 GRS/GRC on Staphylococcal Diseases! Make sure to get your abstracts submitted for the opportunity to present your work in beautiful Barcelona! https://t.co/cADwDFte3e @turley20_mary

[Gowri Muthukrishnan @Gowrishankar3M]

Ringing in 2025 with an exciting study! In this preprint, we show that T cell exhaustion underlies bone infections, and serum TIM-3 levels can predict poor clinical outcomes in patients. @ROC_CMSR @UR_Med @UofR #URochesterResearch
https://t.co/FyT6ns1zse

[Gowri Muthukrishnan @Gowrishankar3M]

Thank you prof. @barbara_broker and Dina Raafat for inviting me to the beautiful #Greifswald to present our exciting work on Bone Infections @UR_Med @ROC_CMSR @UofR. It was wonderful to see you again and discuss exciting science at your amazing University #URochesterResearch

[Gowri Muthukrishnan @Gowrishankar3M]

Congratulations @katyamcdonald on passing your PHD qualifying exam with flying colors. #ProudPI @ROC_CMSR @UR_Med @UofR @URMC_MBI_IMV #URochesterResearch

[Gowri Muthukrishnan @Gowrishankar3M]

What an amazing #AAI2024 meeting. It was wonderful meeting old friends and making new. A huge thanks to @ImmunologyAAI for supporting the Muthukrishnan Laboratory @ROC_CMSR @UR_Med with a Careers in Immunology fellowship.

[Michael Fischbach @mfgrp]

How to pick a problem. Today in @CellCellPress. 1/53
https://t.co/Id4YaXWuup

[Gowri Muthukrishnan @Gowrishankar3M]

Happy to see this study published! We used a humanized mouse model of bone infection to study #MRSA pathogenesis. @ROC_CMSR @UofR @ASBMR #URochesterResearch

[JBMRPlus @JBMRPlus]

This #JBMRPlus study highlights the pivotal role of PVL during acute implant-associated osteomyelitis in humanized mice @Gowrishankar3M @martijnriool @OUPMedicine
#openaccess #freetoread

Read more here: https://t.co/oFNwcLSUQL

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[Gowri Muthukrishnan @Gowrishankar3M]

@KingOfPathogens @ProfAndrewMac @ImmunityCP Woohoo IL-27…I am fully endorsing this amazing cytokine…

https://t.co/sGoqyo1dRV

https://t.co/qwHFzKkxqi

[Harmit S. Malik @HarmitMalik]

In honor of conference season starting shortly

From @PHDcomics

[University of Rochester Medicine CMSR @ROC_CMSR]

Our first-ever CMSR Game Day Basketball Fundraiser! The Cadavaleers (Trainees) will battle with the Bone Collectors (Faculty) in what is sure to be an epic game - Saturday 2/4. Which team has the advantage? RT but importantly, come & support your favorite! #URochesterResearch

[Gowri Muthukrishnan @Gowrishankar3M]

@Awad_Lab @BugsInBone @markkenney_3 Defense is all that I got.. of course I am a good bench warmer too. Planning to do a lot of that with @ChiaLungWu

[Gowri Muthukrishnan @Gowrishankar3M]

@ROC_CMSR @lauracalvi3 Huge congratulations @lauracalvi3

[Gowri Muthukrishnan @Gowrishankar3M]

@SchwarzLab_URMC @Jess_E_Schwarz @Penn Huge congratulations Dr. J Schwarz!

[Gowri Muthukrishnan @Gowrishankar3M]

Amazing day of science @ROC_CMSR 2022 annual symposium @UofR @UR_Med. Outstanding poster presentations by lab members @Kyra_Sandercock and Motoo Saito #ProudPI

[NASA Webb Telescope @NASAWebb]

👀 Sneak a peek at the deepest & sharpest infrared image of the early universe ever taken — all in a day’s work for the Webb telescope. (Literally, capturing it took less than a day!) This is Webb’s first image released as we begin to #UnfoldTheUniverse: https://t.co/tlougFWg8B

[Gowri Muthukrishnan @Gowrishankar3M]

Amazing July Issue Cover @NatureRevMicro! Thank you for featuring our Review on the Cover. @ROC_CMSR @UofR @UR_Med

[Nature Reviews Microbiology @NatureRevMicro]

📢Our July issue is now live!

Read it here:
https://t.co/wRsvZkMNVj

The cover is inspired by a Reviews on life and death in the soil microbiome, and skeletal infections:
https://t.co/lgyjtiSnl1 & https://t.co/44VriJK5Cg

[Gowri Muthukrishnan @Gowrishankar3M]

@markkenney_3 @URochester_SMD @RocMSTP @ROC_CMSR Huge congratulations Dr. Kenney!

[Gowri Muthukrishnan @Gowrishankar3M]

@jenanolikMD @CellReports @anolik_lab @danaorange @Donlinlab @FanZhang_Jessie @soumya_boston @NIH @URMC_DeptMed @URMC_AIR @ROC_CMSR Huge congratulations!