GuccioneLab

The Guccione lab is interested in identifying new therapeutic targets in oncology.

[Miriam Merad, MD, PhD @MiriamMerad]

Excellent article that highlights the contribution of NIH grant funding to fueling economic activity. An important read especially for non- scientist to understand how disruptive NIH cuts are both to medicine and to the economy.

[GuccioneLab @GuccioneLab]

Awesome opportunity

[Mark Dawson @MAF_Dawson]

We are looking for a talented postdoctoral bioinformatician ⁦@TheDawsonLab⁩ to work with us on single cell multiomics incorporating lineage tracing and spatial technologies- we specifically want someone curious, fearless with a licence to innovate!! https://t.co/gBpTDjb3kI

[Miriam Merad, MD, PhD @MiriamMerad]

Strong article from Tom Maniatis, head of the NY Genome Center, on the history of the NIH and its role in maintaining U.S. scientific leadership. Safeguarding the future of biomedical science in the United States: Cell https://t.co/bBzxZzR5ir

[GuccioneLab @GuccioneLab]

Here we characterize PRDM10 as an essential maternal transcription factor and dissect its role in regulating oocyte maturarion and oocyte-to-embryo transition!
On to the next!

Congrats to @meschmi the true mastermind behind this work!
https://t.co/npH4jdSzgA

[Mount Sinai Tisch Cancer Center @TischCancer]

New in @Nature: Human-correlated genetic models identify precision therapy for liver cancer
https://t.co/56Z7bThBB2
Josep Llovet and team @IcahnMountSinai validated the molecular profiles of preclinical models against human HCC data. #livercancer #HCC

[AACR @AACR]

Myeloid Cell Checkpoints: Ido Amit, Florent Ginhoux, and Miriam Merad addressed this topic in a symposium at the inaugural AACR IO Conference on Discovery and Innovation in Cancer Immunology.
#AACRIO25 @IdoAmitLab @FGinhoux @MiriamMerad

[GuccioneLab @GuccioneLab]

Now more than ever the message is: this research can soon have an impact on people’s lives. Do not defund science!Proud of this collab with @kimioishi and the whole #RNA modulation for therapeutics Lab (kudos to JinRong in particular!) https://t.co/xun0whrEX8

[Miriam Merad, MD, PhD @MiriamMerad]

"More than 99% of new drug approvals (2010-2019) were funded by NIH. Why dismantle the engine that made the U.S. a world leader in innovation and drug development ? #DoNotDefundScience https://t.co/JHbFp9dTv2

[Gaetano Gargiulo & ggargiul.bsky.social @ggargiul_2020]

Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution. https://t.co/I0H9lWwlES

[AACR @AACR]

The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. We urge Congress to restore stability to NIH: https://t.co/lK1chJyh1j

[GuccioneLab @GuccioneLab]

@kylechasse An egg today is better than a chicken tomorrow? The impact on the health system will be catastrophic for Americans, regardless or what they voted and they will see people they love die instead of being cured. But this will happen in 5 years, so it’s easier to enjoy a vacation now

[GuccioneLab @GuccioneLab]

@Free_of_CANCER Interested to learn more about the approach. Familiar with DAOs and the crypto ecosystem. Please reach out
to discuss this further.

[GuccioneLab @GuccioneLab]

https://t.co/iG1LQEodpb

link to check whether any study section is still happening. If NIH cannot post the study section on the national register then it cannot formally happen. The ripple effects can be devastating if no new funding is awarded.

[GuccioneLab @GuccioneLab]

What an amazing cover! Congrats ⁦@glogliiita⁩!!

[GuccioneLab @GuccioneLab]

Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder ⁦@Sleemmzz⁩ A huge thanks to all our collaborators ⁦@ggargiul_2020⁩ @nickbar36316207 ⁦@owen_sansom⁩ ⁦@NIHFunding⁩ https://t.co/oKmJ76KIlw

[GuccioneLab @GuccioneLab]

It's out! If you look for a reliable reporter system for your Nucleic Acid Therapeutics needs, we got you covered!
The NATURA system is available to the community on Addgene. Congrats to Tommaso Tabaglio for leading this incredible effort! https://t.co/fIjdkHJZnn

[Andrea Sottoriva @AndreaSottoriva]

Fantastic #PhD opportunity in #DataScience at @Sissaschool in #Triest, #Italy. Applications from #Bioinformatics to #cosmology and #Neuroscience. Deadline Feb14! https://t.co/oAmGmu5iTO

[Gaetano Gargiulo & ggargiul.bsky.social @ggargiul_2020]

End-of-the-year preprint 🧵! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?

[GuccioneLab @GuccioneLab]

@raimondi_ivan Very cool!

[GuccioneLab @GuccioneLab]

@OstuniLab Finally an interesting paper on phase separation