Haoxing Xu

Interested in molecular physiology of organelles, ion channels in the lysosome and lysosome storage diseases; father of two boys

[Jay Tan @JayXiaojunTan]

Today @NatureCellBio, we present a current view of lysosomal biology in aging and evaluate emerging therapeutic strategies. It has been a remarkable group effort from @AgingPitt.
Free PDF here https://t.co/k4Q88A1uKq

[Haoxing Xu @HaoxingXu]

@aakritijain24 @Nature @clairegoul @RobertoZoncu Congrats!

[Haoxing Xu @HaoxingXu]

@SuhongXu_ZJU Congrats Suhong and all co-authors !

[Suhong Xu @SuhongXu_ZJU]

It is unexpected for us to find this protein, MAI-1, which turns out to be important in sensing and detecting mitochondrial membrane damage.

[Roberto Zoncu @RobertoZoncu]

Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. https://t.co/ZdGtlU0wke

[Haoxing Xu @HaoxingXu]

@RobertoZoncu @clairegoul @aakritijain24 Congrats Roberto and all co-authors !

[Cell Biology J-Club @cell_club]

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair | The EMBO Journal | Springer Nature Link https://t.co/kI5UN0RzMJ

[HHMI @hhmi_science]

After 50 yrs in science, former #HHMIInvestigator David Clapham’s advice is simple: “You have to see problem-solving as fun.” From training w/Nobel laureates to deepening our understanding of ion channels & leading at HHMI, he retires with a lasting legacy https://t.co/oxpxWFrgV5

[Jay Tan @JayXiaojunTan]

STING drives inflammation and aging pathology. Today, @Nature, we show that PI(3,5)P₂ is an endogenous ligand that cooperates with cGAMP to trigger STING activation — revealing a new nexus for disease intervention. Here is the PDF https://t.co/2nVbxX8wWR

[Roberto Zoncu @RobertoZoncu]

In this new review, @aakritijain24 and I cover some of the latest molecular mechanisms that underlie the nutrient-and stress-sensing abilities of the lysosome. We then take a deeper dive into how lysosomal regulation impacts the immune and nervous systems. Enjoy!

[Journal of Cell Biology @JCellBiol]

Are you headed to @KeystoneSymp meeting on #Autophagy next week? Get in touch with our Scientific Editor Dan Simon, who is attending! Discuss your research and ask any publication-related questions in-person 💬 ✍️
✉️ Email Dan: https://t.co/18AkVLGjNH

#KSAutophagy26

[Haoxing Xu @HaoxingXu]

Thank you Dr. Stagi @MassimilianoS16 for highlighting our recent work https://t.co/LxeORqkeqI . Two ongoing projects from the lab will reveal what else are underneath the “veil” —-stay tuned! @YutongZhang10 @NatureCellBio

[Haoxing Xu @HaoxingXu]

https://t.co/EoGYcBvu6L

[Haoxing Xu @HaoxingXu]

https://t.co/hfmPKASXGJ Congrats to Yutong , meiqin , yaping, Xin, and all co-authors. Acidic lysosomes are acidic on both sides !

[Science Magazine @ScienceMagazine]

In a new Science study, researchers show that lysosomes, degradative organelles activated by food limitation, stimulate epigenetic changes that contribute to transgenerational longevity in C. elegans.

📄: https://t.co/XoUpycVY1H
#SciencePerspective: https://t.co/o2rjQdO1zB

[HHMI | Janelia @HHMIJanelia]

🥼 New research from the Wang Lab reveals a novel connection between lysosomes & the epigenome and provides new insights into how lysosomes regulate longevity over generations & drive the histone-based transfer of epigenetic information between cells.
🔗 https://t.co/xiOgp1WbGN

[Haoxing Xu @HaoxingXu]

Congrats to Nan , Jingzhi , Meiqin , and all co-authors for the publication of LysoH2 story . SLC7A11 is an unconventional H+ transporter in lysosomes: Cell https://t.co/qeI9HUaj5l

[Journal of Cell Biology @JCellBiol]

A STING–CASM–GABARAP pathway activates LRRK2 at #lysosomes, say Amanda Bentley-DeSousa (@abentleydesousa ), Agnes Roczniak-Ferguson, and Shawn Ferguson (@Shawn__Ferguson) @YaleMed: https://t.co/cmOmrg4QBm

#Disease #CellSignaling #Organelles #Parkinsons

[Journal of Cell Biology @JCellBiol]

TPRML1 activation mitigates saturated fatty acid-induced oxidative damage by boosting #lysosome biogenesis and #mitophagy. From Feng, Cai, @HaoxingXu et al @ZJU_China suggesting that lysosome activation is a viable strategy for alleviating oxidative damage https://t.co/WxS4Ijj2wG

[Haoxing Xu @HaoxingXu]

Lysosomal catabolic activity promotes the exit of murine totipotent 2-cell state by silencing early-embryonic retrotransposons: Developmental Cell https://t.co/fSnpuIiC6p