Hasanga Manikpurage

Genetic of cardiovascular diseases
Post-Doc Fellow @Cambridge_Uni @DPHPC 🇬🇧
PhD @universitelaval @IUCPQ 🇨🇦
MSc @univ_paris_cite @lvts🇫🇷

From 🇫🇷/🇱🇰

[Hasanga Manikpurage @HasangaDM]

Wow!!! Many Thanks to @JeanetteErdmann, @konradtsawicki and @Circ_Gen for highlighting all the major points of our paper through this video!

[Circulation: Genomic and Precision Medicine @Circ_Gen]

⚡️ Now online from Thériault + team: A Polygenic Risk Score for #CoronaryArteryDisease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men https://t.co/H6Z85PAp4u

@AHAScience #AHAjournals #CardioGen

🎬 @JeanetteErdmann @konradtsawicki

[Human Genetics and Genomics Advances @HGGAdvances]

📣New from Zamani et al!
📄Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets
🫀🧬
👉https://t.co/Pw7P94SSRh

[Hasanga Manikpurage @HasangaDM]

Thank you to all colleagues involved in this project, supervised by Dr. S. Thériault. Thank you also to all scientists and participants involved in @_CARTaGENE_ , @clsa_elcv and Biobanque de l’@IUCPQ.

[Hasanga Manikpurage @HasangaDM]

📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @CommsMedicine. We benchmarked a set of PGS for CV traits available from the @PGSCatalog resource in different Canadian cohorts🇨🇦.
See more 👇🏽 - Link (OA):
https://t.co/FQlOysUpML
(1/5)

[Hasanga Manikpurage @HasangaDM]

- CAD-PGS is associated with the extent of coronary artery damage observed.
- In this study, not all CV-PGS are associated with the severity of CAD; lipid-PGS are.

[JAHA @JAHA_AHA]

In patients with calcific aortic valve stenosis, lipoprotein(a) levels predict a higher risk of valvular and cardiovascular outcomes. #AHAJournals @HasangaDM @ClavelLabo @PPibarot @ArsenaultBenoit https://t.co/owhTIoF3gq

[Marios Georgakis @MariosGeorgakis]

2⃣Bridging genomics, transcriptomics, proteomics, and metabolomics

In a rare combination of all 4 major omics layers, this study offers a great resource for dissecting the links between genetics, expression/slicing, molecular traits and disease risk

🔗https://t.co/Om6A7YXIdO
📊summ stats: https://t.co/qvnRKq3hVK

[Pradeep Natarajan @pnatarajanmd]

The common IL6R p.Asp358Ala missense variant is associated with 5% ↓odds for CAD (inhibiting pathway validated & more inhibitors in RCTs), & 5% ↓odds for rheumatoid arthritis (w approved inhibitors for pathway).
New study shows even greater (10% ↓odds) for AAA.
https://t.co/0qU1zQJiUS

[Hasanga Manikpurage @HasangaDM]

Work supervised by Dr. Sébastien Thériault
With many great contributors: @Jebou326, @egagnon_phd, @gobeil_emilie, @girard__arnaud, @YohanBosse, @ArsenaultBenoit and many others that don't have a twitter handle -
From @IUCPQ, @universitelaval

[Hasanga Manikpurage @HasangaDM]

Finally! Happy to share my 3rd PhD paper, now published in @ATHjournal! 🚀 This study explores the impact of integrating multiple independent lipid PRSs with a CAD-PRS for CAD incidence prediction in @uk_biobank.

👉🏽Link (Open Access! 📖): https://t.co/SCDXm5Lzcy

[Pradeep Natarajan @pnatarajanmd]

Great collaborative work spearheaded by @DrMArdissino @aidanbutty showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events https://t.co/xaQuZyqc39 @Circ_Gen

[EJPC Editor-in-Chief @EJPCEiC]

Lipoprotein(a) is an independent predictor for long-term in-stent restenosis and should be considered in the evaluation of patients undergoing PCI.
https://t.co/4lUH5tnR2h
@escardio @AboyansV @SilCastelletti @PeroneFrancesco @andreagallardo #cvprev

[Loïc Lannelongue @Loic_Lnlg]

London -> Barcelona by train ✅ (surprisingly easy! 🚄)
Just arrived for the 2024 @nextflowio Summit, very excited to be delivering the keynote tonight on this mildly intimidating stage (tech tests ✔️, Segrada Familia ✔️ … we’re ready to roll)

[Dipender Gill @dpsg108]

Probably the most important paper I will ever write https://t.co/kmeGvEe5hj @stevesphd @BMCMedicine

[Tregouet David-Alexandre @TregouetBPH]

The catalog of all possible SNVs altering existing upORFs or creating new ones (via both canonical  and non canonical TIS) in human transcripts is available on the mobidetails platform (
https://t.co/Na1LRA5y66) @soukarieh_omar @BPH_Research @univbordeaux_EN

[Ron Do @DoGenetics]

Our new study published in @NatureComms, led by Ghislain Rocheleau and team.
Using TOPMed WGS data, estimate heritability of CAD is 34%.
Ultra-rare variants with low LD score contribute ~50% of the heritability.
Enrichment in several functional processes.
https://t.co/k7bFrUlcsb

[PGS Catalog @PGSCatalog]

>5000 Polygenic scores now available at https://t.co/63bPMToDLE! As of today's release we've broken 5k PGS, indexing data from 673 unique publications. A big thank you to the authors submitting their data and our team in pursuit of #openscience, #FAIRdata, and reproducibility!

[Pradeep Natarajan @pnatarajanmd]

Fantastic @Nature News Feature by @AnilOza16-
Why does heart disease affect so many young South Asians?
Highlights our ambitious goals with @ourhealthstudy & others like @masala_study.
https://t.co/LWjZ9WYuh0

💜 https://t.co/htwIQvmA5l 💜

@HeartDocSadiya @alka_kanaya @NammiKan