Interested in how obesity influences autoimmunity in the context of arthritis? Please check out our paper which implicates IFN type 1 signaling in T cells. Much thanks to #ANRF for funding this project!
Faust, Brenner et al. @BrighamWomens@harvardmed show that type I IFN signaling contributes to #arthritis pathogenesis in obesity through activation and expansion of CD8 T cells in visceral adipose tissue and synovium. https://t.co/tbNc8Fb1GV
#Autoimmunity
Have you ever wondered how homeostasis is maintained in human synovial tissue? Read our paper describing how fat helps maintain homeostasis through the activation of cortisol! This circuit is disrupted in arthritis, leading to fibroblast dysfunction: https://t.co/yaUVX8DElm
#MakeRheumForHer Celebrate with us another group of women who are making valuable contributions to the field of Rheumatology. With the support of our research grants, they are breaking barriers and finding solutions towards a cure. #CureArthritis
We would like to thank all the attendees, speakers, sponsors Abbvie and Lilly, CME Grant Supporters Janssen and Pfizer, leadership, and staff for making this weekend a success. #CureArthritis#2024ANRFSymposium
The 2024 Annual Research Scholar Symposium has begun! We can’t wait to hear about the latest discoveries that will improve outcomes and change the patient experience! #2024ANRFSymposium#curearthritis
Very excited that our preprint “Extracellular matrix scaffold-assisted tumor vaccines induce tumor regression and long-term immune memory” is now online! Congrats to @Sanjay_Pal7 for and thanks to the NCI IRP @NCIResearchCtr for support. https://t.co/R9jpdAZYdP
An excellent effort by @TravisFaust2 and @FeinbergPA in the lab. For anyone using #microglia CreER lines, this study compares the varying degrees of recombination for some of the most widely used lines. I hope this helps the community. https://t.co/4sWxdatfPY
Incredibly excited to share our GzmK+ CD8 T cell paper, this week's @ScienceTM cover! GzmK+ (Ttek) CD8 T cells are a major tissue T cell pop in RA and other diseases, & TCR repertoire indicates they are distinct from CTLs. Loved collaborating w @FanZhang_Jessie & @soumya_boston
Super proud of @HeatherJFaust for her early-career grant from @CureArthritis! 😍
“Adipose Tissue as a Memory T Cell Storage Site in Inflammatory Arthritis”
It was a pleasure to work on this review on activity-dependent synaptic pruning 🍡🥠 @NatRevNeurosci with Georgia Gunner and @SchaferLabUMCMS. We covered:
-Model circuits
-Immune mechanisms
-Cell death molecules
-Neurodevelopmental disorders
🙏Enjoy😊
https://t.co/BEBh9jMePI