Dennis Hoving

MSCA Post-doc fellow at LUMC, Netherlands.
Infectious diseases and B cell immunity

[Dennis Hoving @HovingDennis]

Excited to see my first post-doc paper out in @CommsBio! We developed a method to study bacterial polysaccharide-specific B cell responses in PBMCs using spectral flow cytometry. [1/5]

https://t.co/jKbrm32wvU

[Dennis Hoving @HovingDennis]

Nature Reviews Microbiology surely keeps me engaged during literature research with their wild title choices 😅

[Iannacone Lab @iannaconelab]

💥 Exciting News! Our latest research is now online @NatImmunol! Discover how prior infection or vaccination provides antibody-independent protection against heterologous SARS-CoV-2 challenge! 🧵🔬 (1/10)
https://t.co/G3EYjGut9q

2/ 🛡️ Shifting paradigms, our research highlights T cells' paramount role in defending against COVID-19 beyond antibody responses. Even in the complete absence of antibodies, T cells stand guard.

3/ 🧬 Our study utilized advanced mouse models, including a pioneering human/mouse ACE2 hybrid, to unveil that T cell immunity effectively counters various SARS-CoV-2 strains without relying on antibodies.

4/ 💪 Highlight of our findings: CD8+ T cells are crucial for combating severe infections, complemented by CD4+ T cells in less severe cases. The linchpin? Interferon-gamma (IFN-γ), driving this antibody-independent protection.

5/ 🔄 Demonstrated across models mimicking the spectrum of disease severity, this research shows that T cells not only prevent disease but also curb early SARS-CoV-2 replication.

6/ 📚 Building on the collective efforts of many in the field, our study underscores T cells' essential and sufficient role in safeguarding against SARS-CoV-2, reinforcing the critical importance of cellular immunity in the fight against COVID-19.

7/ 🌐 While our findings support vaccine strategies enhancing T cell responses, it's essential to acknowledge the efficacy of current vaccines in eliciting T cell immunity. We advocate for evaluating T cell responses alongside antibodies to fully assess vaccine effectiveness and explore targeted strategies for optimal T cell activation.

8/ 🙌 A heartfelt thank you to our incredible team and collaborators, especially lead author @ValeFuma91, along with key contributors Micol Ravà and Davide Marotta, as well as our collaborators Luca Guidotti, Marco Bianchi, and Raffaele De Francesco.

9/ 🌟Appreciation to our supporters @ERC, @AIRC_it, @EMBO_YIP, @ArmeniseHarvard, @mur_gov_, @SanRaffaeleMI, @MyUniSR, Fondazione SAME, Fondazione Prossimo Mio. Thanks also to our reviewers and Nick Bernard for their invaluable contributions to our journey.

10/ Dive deeper into our study to grasp its impact on immunology and future vaccine development. We're eager to hear your thoughts and engage in discussions! https://t.co/G3EYjGut9q. Your feedback and insights are invaluable. 📖💭

[bioRxiv Immunology @biorxiv_immuno]

CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment https://t.co/BngA3eSB0X #biorxiv_immuno

[Openly 🏳️‍🌈 @Openly]

🇬🇷 The Greek government’s bill legalising gay marriage and adoption rights received widespread support among parliamentarians during a debate on Monday.

💍 If passed, Greece will become the 37th country and first orthodox one to recognise same-sex marriage in national law.

[Trends in Immunology @TrendsImmuno]

B cell phylogenetics in the single cell era https://t.co/nymSGzW03Z #immunology

[Carlos Minutti @CarlosMMinutti]

🔥The Champalimaud PhD Program call in #Cancer and #Neuroscience is now OPEN! Apply by Jan 31st.
👉+Info here:

https://t.co/QuyHpjiSJm

We are recruiting enthusiastic students - come research #Cancer #Infection and #Immunity with us in beautiful Lisbon! @Neuro_CF @ChampalimaudF

[Dennis Hoving @HovingDennis]

@Leonard_deBoer @TheCrick @TybulewiczLab @NatureComms Congratulations!!! Both on the paper and the entertaining thread ;)

[Otto Más 🎙️ @Otto_Mas]

¿Puede ser más bonito y más triste a la vez? 😭

[Evangelos Giampazolias @giampazolias]

💥Exciting PhD opportunity in my lab at @CRUK_MI to study how host-microbiome interactions and cell death shape anti-cancer immunity.

⏰⏰Deadline: 8 December 2023

💥If you are interested in cancer immunology don't miss the opportunity! Apply👇
https://t.co/8A0sV5TeYE

[Immunity @ImmunityCP]

Online now: Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants https://t.co/hmwl9cc1N7

[Caetano Reis e Sousa @ReiseSousaLab]

Very happy that our latest paper on regulation of DNGR-1-mediated cross-presentation is out in Cell Reports https://t.co/xwLoe1LcMB

[James Pearson @JAPearsonLab]

Interested in learning about Tregs and circadian rhythms in Type 1 diabetes? Then register for the @TheSTEMvillage seminar I will give on Monday 4-4.30pm! https://t.co/1DGsDFkIik @JDRFUK @CUmedicengage @The_MRC

[Rob Heyderman @RHeyderman]

Pneumococcal carriage 2 Genotype 2 Phenotype. 2 yrs from submission to publication but worth it! Carriage surveillance at scale in Malawi @MLW_Programme @KUHeS_mw @LivUni Genome analysis @UCLInfectImm @UriObolski @SunetraGupta @MaidenLab Phenotyping @ucl
https://t.co/7N1JCJDoel

[Mikel Chamizo @MikelChamizo]

Mi pequeño homenaje a Ibarrola, con la obra que compuse hace unos años sobre el bosque de Oma, usando ramas, piedras y los sonidos del propio bosque.

https://t.co/Y6acWBiXRN

[Dennis Hoving @HovingDennis]

@claudiobussi @Nature @TheCrick @maxgabgut Congratulations!!!

[Dennis Hoving @HovingDennis]

@maxgabgut @claudiobussi @agumangia @DimovaLab @vainhilla96 @SaricLab @ERC_Research Thats fantastic!! Congratulations Max, Claudio and the rest!!

[Max Gutierrez @maxgabgut]

Thrilled to see this out! Fantastic work driven by @claudiobussi in collaboration with @agumangia @DimovaLab @vainhilla96 @SaricLab We discovered a function for stress granules during membrane damage. Very relevant for #tuberculosis =ZNFX1 Thanks everyone and @ERC_Research 🙏

[Mikel Chamizo @MikelChamizo]

Desnudo como una serpiente,
hambriento como un lobo,
asustado como un ladrón inexperto,
llego a las ciudades de la niebla.

Me gustaría, incluso mucho,
comer gratis,
fumar gratis,
pensar gratis,
y gratis, no dar explicaciones.

[Daniel Gould, MD, PhD @DJGould94]

I swear I'm really going to read that article believe me

[Elena Mitsi @ElenaMitsi]

Our paper on the first human pneumococcal challenge study with genetically modified live attenuated pneumococcal strains is now online on AJRCCM. https://t.co/Fxqv9fC9Rh
A great collaboration with JeremyBrown, HelenHill @microelisa, @danielavaccines.