Guerrero-Cazares lab

Neurogenesis and Brain Tumors Lab @MayoClinic. We study interaction of glioblastoma with factors of the SVZ 🧠 . Views expressed are our own.

[Guerrero-Cazares lab @HugoGuerreroLab]

Today, in front of a packed room, @marissarussoo successfully defended her PhD thesis studying #extracellular_vesicles in #GBM and #NSC Congratulations Dr. Russo! 🎓 it has been a privilege to serve as your mentor these years and I can’t wait to see your future success!

[Andres Moreno-Estrada @morestrada]

Second time the MX biobank project (https://t.co/qaLnfPzcz2) gets the cover in a @Nature journal! This time in @NatureMedicine highlighting the work by @BarjonCar on Clinical genetic variation in Mexico. Another amazing cover by @mauguz33! https://t.co/k3eGLX4809

[Guerrero-Cazares lab @HugoGuerreroLab]

New paper by @marissarussoo A novel methodology to purify high quality #extracellular_vesicles from #GBM cells and profile their protein content. Collab with @emilynorton295 @DoctorQMd @verobelzil and Tukiet Lam
📘JEV @IsevOrg https://t.co/emzZnKdMRV

[Dr. Alfredo Quiñones-Hinojosa @DoctorQMd]

Putting the brightest inquisitive minds together to find cures for cancer
@MayoClinicNeuro
@MayoClinic
@MayoCancerCare
@HopkinsNsurg
@HopkinsEngineer
@JohnsHopkins
@uminn
@UMBaltimore
@KKLabJHU
#washDC
@paosmeade
@HugoGuerreroLab
@Honggangcui
@MayoInvents
Inspiring

[Dr. Catharine Young @DrCatharineY]

Down over 60%. That’s how far federal research funding has fallen compared to this time last year. Every delay in funding is a delay in delivering for the health of American people.

[News from Science @NewsfromScience]

“The impact of the collective executive orders and directives appears devastating.” https://t.co/X62t5p8M7O

[Mayo Clinic Neuro @MayoClinicNeuro]

This weekend, we are featuring Dr. Ian Parney. Listen in as he shares how impactful practicing at a teaching hospital is and the positive impacts it has on providing the best patient care and outcomes. @IanParneyMDPhD #Neurosurgeon #NeuroTwitter #MayoClinic

[Guerrero-Cazares lab @HugoGuerreroLab]

🥂to another great @NeuroOnc meeting during #SNO2024! We had a great time with new and old friends and planning projects with upcoming stars! See you again for #SNO2025! In #Hawaii @paosmeade @aurafig @garciaCesar_A @steph_jeanneret @countryPandey @eugeniaturino

[Paola Suárez Meade, MD @paosmeade]

Thanks @NeuroOnc the opportunity to present our work on GBM Invasion and ECM stiffness!! Very excited to be here and learn from leaders in the field! #SNO2024 @DoctorQMd @DoctorQMDLab @paulaschiappa1 @emilynorton295 @HugoGuerreroLab @tae_hwang @KKLabJHU #NeuroOncology #GBMResearch

[Dr. Alfredo Quiñones-Hinojosa @DoctorQMd]

Proud of our team @MayoClinicNeuro @mayoflnsgyres @DoctorQMDLab @HugoGuerreroLab @paulaschiappa1

[Guerrero-Cazares lab @HugoGuerreroLab]

2 new NIH grants coming at the same time! We are #hiring now. Looking for a new #postdoctoral fellow to join our team. Recent #PhD graduate with skills in #cancer_biology #cell_culture #multiomics and #in_vivo_models
@MayoClinicNeuro More info: https://t.co/fL8Xhlgd21

[Dr. Alfredo Quiñones-Hinojosa @DoctorQMd]

Magnificent talk @NINDSdirector @MayoClinicNeuro @MayoClinic a golden age. Extraordinary leader and visionary. So much appreciated Dr Koroshetz @NINDSDiversity @NIH_NINDS @NIH

[Juan P. Navarro-Garcia de Llano, MD @jpnavarro_md]

Tremendous talk today by @NINDSdirector as our The James C. and Sarah K. Kennedy
Dean of Research Lecture Speaker.
@DoctorQMd @HugoGuerreroLab @emilynorton295 @paosmeade @JEmilianoSG @lmichmd @ManuelaAB99

[Guerrero-Cazares lab @HugoGuerreroLab]

In patients, the expression of cathepsin B is increased in GBM areas proximal to the lateral ventricle.

[Guerrero-Cazares lab @HugoGuerreroLab]

🚨📄On our new publication in @ScienceAdvances, @emilynorton295 uses #Cell_Specific_Proteomics
to uncover how cathepsin B drives #GBM malignancy near the #SVZ and induces
#Neural_Stem_Cells #senescence This breakthrough offers new insight for #GBM
https://t.co/PgjISUFeYO

[Guerrero-Cazares lab @HugoGuerreroLab]

Back to in vivo, silencing cathepsin B expression not only improves the survival of animal models but also eliminates the negative impact of proximity to the lateral ventricles.

[Guerrero-Cazares lab @HugoGuerreroLab]

📊 First, in immunocompetent models, we observed that proximity to the lateral ventricle negatively impacts survival, mirroring human data. Additionally, SVZ cells show reduced proliferation and become arrested as B cells.