Isaac Witte

PhD Student in @liugroup | Berkeley 2020

[Isaac Witte @IPWitte]

Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, product of a close collaboration between @liugroup and @sternberglab, has been such a fun journey to help lead throughout my PhD. Huge thanks to all contributors!

[David R. Liu @davidrliu]

Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab.
1/13
https://t.co/ZLHtZm5Gmw

[Nicholas Krasnow @NicholasKrasnow]

We’re sharing today how redesigning proteins with AI enhances their evolution. Redesign raises the fitness that proteins evolve for new function, expands the solution space, and even accelerates adaptation. We harness this finding to reprogram more potent, precise, and stable proteases for therapeutics. Out in @Nature:

[Isaac Witte @IPWitte]

@Planaria1 Thanks, Alejandro!!

[nature @Nature]

An innovative genome-editing tool promises to do what original CRISPR systems have struggled to achieve: insert entire genes, precisely and efficiently, into human DNA

https://t.co/NtsMKiCEwG

[Isaac Witte @IPWitte]

evoCAST plasmids can be found on addgene here: https://t.co/zCZGtRiaKu

Looking forward to the new chapter of CAST in mammalian cells!

[Isaac Witte @IPWitte]

Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, product of a close collaboration between @liugroup and @sternberglab, has been such a fun journey to help lead throughout my PhD. Huge thanks to all contributors!

[David R. Liu @davidrliu]

Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab.
1/13
https://t.co/ZLHtZm5Gmw

[Nature Biotechnology @NatureBiotech]

CRISPR–Cas12-based detection of SARS-CoV-2 https://t.co/9a1EpScYwx

[Eric N. Olson @Transactivator]

A patient sees his own cells making the missing dystrophin protein. A shared moment of inspiration and motivation. https://t.co/ibqGqRrjRo

[Chicago Symphony Orchestra @chicagosymphony]

.@MaestroMuti with the @UCBSO during an open rehearsal at Hertz Hall - presented by @calperformances at @UCBerkeley. #CSOonTour