Conan O'Brien

I'm fascinated with how the immune system can be harnessed for therapeutic benefit. DPhil student in Cardiovascular Science at the University of Oxford.

[Conan O'Brien @ImmunOBrien]

Check out this thing I wrote! Macrophages back at it again! Adipose tissue-resident macrophages direct fat storage in adipocytes through PDGFcc, which can be inhibited by antibodies to reduce adiposity & body weight👨‍🔬Great work from the Geissmann lab! https://t.co/Q9gC1yqRMH

[Conan O'Brien @ImmunOBrien]

So you think macrophages are “just” immune cells? Well then I fear you haven’t been paying attention…

Macrophages are essential regulators of the endocrine axes controlling how our bodies work. Check out this review I wrote to learn more about it 🧫🧪

https://t.co/qEFYQjmR84

[Conan O'Brien @ImmunOBrien]

Microglia are the brain's resident immune cells. Their job is to patrol the brain's blood vessels looking for invading pathogens to gobble up. But what happens when they go rogue?

Great article on brain-macrophages from the BBC

https://t.co/SBOK3EBcqR

[Conan O'Brien @ImmunOBrien]

@LboroSport @lborobasketball Do you know if this game is being streamed?

[Ana Domingos @AnaDomingosLab]

Habemus Doctore @OxfordDPAG ! 🎉 Congrats, Conan O'Brien 🎓 @ImmunOBrien on earning your PhD from @OxfordDPAG! It was a pleasure mentoring you on this incredible journey. Special thanks to Jeremy Taylor and Mikael Karlson for their examination of his exceptional thesis!

[Immunity @ImmunityCP]

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders https://t.co/x0jOgjVnSS

[Conan O'Brien @ImmunOBrien]

Massive congratulations to @Emma_Rose_64 for getting this out before Christmas! Adipose tissue perineurial protect against obesity by promoting thermogenesis in brown adipose tissue! Super cool work and so so well earned!! 🤩👩‍🔬👏👏 See now in @ImmunityCP #neuroimmunology

[Emma Haberman @Emma_Rose_64]

@AmyShergold @ImmunOBrien For anyone wondering what the *completely sober 👀* 5am @bsicongress poster presentation was about...

Now published in @ImmunityCP ! 🔥

🔗👇🏻
https://t.co/ilVJlmksge

[Conan O'Brien @ImmunOBrien]

@mcsinton Thanks Matthew - I enjoyed yours too!

[Conan O'Brien @ImmunOBrien]

What a fantastic #BSI23 and what a pleasure to be able to present my PhD work to such an engaged audience of immunologists! My Fitbit said I was in fat burning mode for the duration of my talk too which may help to offset some of the indulgences that followed! 👨‍🔬🔬🍺 🍔

[Dr Amy Shergold (she/her) @AmyShergold]

Very tired at the last day of #BSI23 after a 5am poster presentation at the afterparty... Invite @ImmunOBrien and @Emma_Rose_64 to your parties if you want some proper immunology entertainment 😅

[Conan O'Brien @ImmunOBrien]

@ScottPLand Thanks Scott!!

[Conan O'Brien @ImmunOBrien]

@AmyShergold Massive congrats Amy!! 🥳🥳 and cya soon!

[Conan O'Brien @ImmunOBrien]

@JudyRSayers @IdrmOxford @GroupRiley @OxfordDPAG Massive congrats Judy! Pint to celebrate soon!

[Conan O'Brien @ImmunOBrien]

Yet another reason why macrophages are awesome 🤩

[Science Immunology @SciImmunology]

Scientists identified a macrophage target in white fat that, when deleted in mice, stunted weight gain, reduced inflammation, and overall protected the animals against #obesity and associated health conditions. @nyugrossman @ufrj

📄: https://t.co/vqe4DOs5z0 #WeekendReads

[Conan O'Brien @ImmunOBrien]

This is pretty awesome

[Science Immunology @SciImmunology]

Dendritic cells can “self-shape” the chemotactic gradients that help them transport antigens to lymph nodes, finds a new live imaging study from @Sixt_Lab @EdouardHannezo.

📄: https://t.co/g6ZCFCfCQW
Focus by @hannahdonnelly_ @EMandrou @robinsall: https://t.co/1G1xcJdKe4

[Аnа Dorrego Rivas @adorrego_r]

Great paper, yet another proof that the fixation you use for your staining can make a huge difference: just look at figures 2 and 7!

https://t.co/00pKRDvpbK

[Conan O'Brien @ImmunOBrien]

Macrophages strike again!

This time, infiltrating macrophages trigger cell death of pineal gland innervating neurons, causing functional denervation, impaired melatonin production, and sleep disruption!

Not “just” immune cells!

https://t.co/pkpBFIB5FF

[Conan O'Brien @ImmunOBrien]

Fascinating new framework for single cell seq analysis I had the pleasure of learning about from Davi himself.

A particularly relevant method for understanding the functional heterogeneity of T cells - check it out!!

[Conan O'Brien @ImmunOBrien]

Is there anything macrophages don’t do??!

[Miriam Merad, MD, PhD @MiriamMerad]

Another powerful study highlighting that macrophages are an untapped source of therapeutic targets with new data showing the role of macrophages atrial fibrillation https://t.co/lejUPiKeQ4