Isnard Pierre

MD, PhD, Kidney Pathology, Institut Necker Enfants Malades, Paris, France

[Katalin Susztak @KSusztak]

🔥🎆Our newest paper is out !!! @NatureGenet How does the kidney build its filtering units, each from the same small pool of stem cells? Jon Levisohn, Alex Hughes lab mapped human kidney development cell by cell, in space, and found it is far more flexible than the textbook teaches. https://t.co/58gdC3ZzpU

[Katalin Susztak @KSusztak]

1/ 🚨 Out today in @ScienceAdvances , and I could not be more excited. ELF3: a GWAS gene that reprograms injured kidney tubules. https://t.co/feIruCdGCK
GWAS have handed nephrology more than 1000 kidney function loci. Here we nail one down: ELF3 is the effector gene at an eGFR GWAS locus. When we delete it in a sick kidney, injured proximal tubule cells turn back toward a normal epithelial state. 🧵

[Katalin Susztak @KSusztak]

👏 📄 awesome paper by Junnan Wu (Susztaklab alumni) -Single cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury | @ScienceAdvances https://t.co/e7h0tqnurn

[Haikuo Li @HaikuoLi]

JCI Insight - Shared mechanisms of organ fibrosis https://t.co/Y5vM7Y4ahi @HumphreysLab

[Nature Reviews Nephrology @NatRevNeph]

Next-generation kidney tissue analysis — spatial omics and digital pathology https://t.co/Yon9TZiJ43

[Katalin Susztak @KSusztak]

Universal cell embedding provides a foundation model for cell biology | @nature @jure https://t.co/Puzph4P85n

[Isnard Pierre @IsnardPierre1]

@NatRevNeph Honored and grateful to @NatureRevNephrol for highlighting our work!

[Nature Reviews Nephrology @NatRevNeph]

HNF1B as a central gatekeeper of tubular homeostasis https://t.co/4uaFFbFb99

[Guillaume Canaud (MD, PhD) @CanaudLab]

Our latest paper just released. Congratulations to Ilaria, Charles and the entire team 🍾🥳🔥Oncogenic PIK3CA mutations shape an immunoregulatory microenvironment in mosaic overgrowth disorders https://t.co/F9Ykt7Yrr7

[Haikuo Li @HaikuoLi]

Check out our recent work on @NatureComms! Greatly appreciate my mentors and collaborators making this possible. We developed epi-Patho-DBiT, a unified platform that enables spatially resolved ATAC -seq or CUT&Tag analyses in FFPE tissues!

[Isnard Pierre @IsnardPierre1]

@HaikuoLi @NatureComms Congrats !!

[Katalin Susztak @KSusztak]

We generated a spatial atlas from 64 human kidney samples to define kidney niches and characterize
fibrosis through injured tubular microenvironments. We built a spatial immune atlas to study renal inflammation, uncovering a B cell-predominant immune microenvironment in DKD that correlated with disease severity and kidney function decline.

[Katalin Susztak @KSusztak]

Congrats to @IsnardPierre1 and Marco Pontoglio HNF1B integrates signals in a feed-forward loop driving kidney disease progression | Happy to have contributed with Jon Levinsohn @ScienceMagazine https://t.co/uKA0gAhUC0

[Isnard Pierre @IsnardPierre1]

Thrilled to share our work! Immensely grateful to my incredible mentors, Fabiola and Marco, to all co-authors, and to Science for publishing and supporting our work !

https://t.co/AQ2rItET37

[Katalin Susztak @KSusztak]

🚨 Our new paper just dropped !!! Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes https://t.co/4WCXVKst5S

[nature @Nature]

Nature research paper: Multiomics and deep learning dissect regulatory syntax in human development

https://t.co/hVYkmZggVQ

[dana_peer @dana_peer]

I am very pleased with our latest paper, spearheaded by 3 incredibly talented first authors @chris_cowley14,@LFSoto12 and @SairajSajjath with @ElaineFuchsLab. Here we show that cells can remember past injury for a long time! https://t.co/lL0VYIyNan

[Jonathan Zuckerman MD PhD @JZRenalPath]

Bx for AKI in a pt on checkpoint inhibitor: neutrophil rich tubulointerstitial nephritis. We would usually think pyelonephritis, high risk neutrophil rich variants of CKI inhibitor AIN have been characterized. https://t.co/wHkozCOZaa #renalpath #pathtwitter #nephrology

[Waggoner Lab @LabWaggoner]

Whole-body molecular and cellular mapping of the laboratory mouse @CellCellPress @UChicagoPME
https://t.co/cOPyNybNpB 🇨🇳🇺🇸

[Guillaume Canaud (MD, PhD) @CanaudLab]

What extraordinary news — I’m extremely proud and honored.
Thank you @eshgsociety for this very prestigious award, which I share with the entire team. 🎉🍾🥂