Yuri Ivanov

[Yuri Ivanov @Itilon]

@Alice01493132 @OptimusRealm @MyLordBebo As far as I could tell, it's more of an issue in certain cities, focused specifically on some houses with historical value. In my city - Sofia - there is no ban whatsoever and no requirement to ask anybody.

[Yuri Ivanov @Itilon]

@OptimusRealm @MyLordBebo I don't know if that's a real thing in the UK, but I live in the EU and we have neither bureaucratic hurdles, nor any other issues when installing ACs.

[Yuri Ivanov @Itilon]

@wzyguy @Noahpinion There is no such nonsense in my country (which is a part of the EU). I assume it's solely the UK.

[Yuri Ivanov @Itilon]

@DrSamuelBHume Well, yes, but even current 100+ year olds spent most of their lives before modern medicine really moved from improving your odds to survive childhood to improving your odds in mid and late life.

[Yuri Ivanov @Itilon]

@terziev Това е много положително развитие, но много скоро и новите тротоари ще бъдат опропастени, ако няма мерки за ограничаване и санкциониране на автомобилите, които непрекъснато спират върху тях.

[Yuri Ivanov @Itilon]

@davidasinclair @Nature What do you mean when you say "rare"? Is that something that already exists outside of trials? Is the price the sole or most important reason it's not common or there are other issues?

[Yuri Ivanov @Itilon]

@jpsenescence I don't think you necessarily need a single intervention that's better than what lifestyle could provide to push longevity medicine forward. Stacking multiple modalities seems to me the more likely road ahead.

[Yuri Ivanov @Itilon]

@statto @KarlPfleger @VitalistBay Is there a video?

[Yuri Ivanov @Itilon]

@statto Your post prompted me to check how does the 1926 cohort compare to the ones before and after it (and also see if Chat GPT can draw a cool infographic). It looks like at least in one meaningful sense 80 is the new 60 now.

[Yuri Ivanov @Itilon]

@siimland ASCVD mortality has been falling since the 1950s and given how good our understanding of the disease and its risk factors is, it would very likely be the next big one. Cancers are just too heterogeneous and too complex and will take at least several more decades.

[Yuri Ivanov @Itilon]

@mkaeberlein Sad to read than. Hopefully the podcast continues.

[Yuri Ivanov @Itilon]

@KarlPfleger Do you consider the "replacement" approach (lab-grown organs, plasmapheresis, hair cloning, etc.) a part of one of these two fields, or something separate from (and presumably complementary to) both?

[Yuri Ivanov @Itilon]

@siimland The problem with these estimates is that they come from cause-delete life table calculations. Real-life impact could (and possibly will) be much higher than the 5-10 years that those imply.

[Yuri Ivanov @Itilon]

@terziev Много добре е станало като цяло, единствено нямаше да е лошо и подовата настилка да почисти.

[Yuri Ivanov @Itilon]

@statto I recently started wondering though, how accurate is the 90 percent really? For example, if a person dies at 20 from a brain tumor, we still count them towards it because cancer risk is clearly age-influenced, but their particular death is not 'caused by aging' per se.

[Yuri Ivanov @Itilon]

@rand_longevity Given the fact that there are only 5 individuals older than 115 now, it's safe to say that not a single person would have gotten to 130 in 15 years. This will not turn into something we routinely do for at least 50 more years even if solve ageing tommorow.

[Yuri Ivanov @Itilon]

@Dr_Singularity That's cool, but this therapy usually decimates your B-cell population for good, making you immunocompromised, so it's not free. We are still far from curing such diseases with no consequences at all.

[Yuri Ivanov @Itilon]

@ydeigin I don't see a lot of reason for 4 and 5, the rest are fine.

[Yuri Ivanov @Itilon]

@DrSamuelBHume If seemingly over 90 percent of the people treated with Teclistamab-Daratumumab go over four year progression free, what is the rationale behind subjecting them to any other lines of treatment?

[Yuri Ivanov @Itilon]

@DrSamuelBHume The long tail improves, but what is the explanation for the steep drop that still happens in the first 24 months?