Jason de Koning 🇨🇦

Associate Professor @UCalgaryMed & @UofCr4kids • Evolution, genetics, computation • He/him • Tweets=opinions 🇺🇦

[Lior Pachter @lpachter]

Sean Eddy developed profile HMMs in the 1990s, ultimately leading to his HMMER project, which includes JackHMMER that AlphaFold relies on. Apparently his work has been determined to be "of absolutely no value to the US taxpayer". Obviously that's not true.
https://t.co/LZgihGGnUk

[Jason de Koning 🇨🇦 @JasonDeKoning]

Wait...you're "testing" if a small number of poor bastards who signed up to give you $$ care if they don't get the same service that every one else gets for the same price? This is supposed to make people feel better? What are you guys doing? You should delete this tweet and apologize.

[Jason de Koning 🇨🇦 @JasonDeKoning]

@joshgonsalves_ Same here. It's too bad, it was really liking its output

[Jason de Koning 🇨🇦 @JasonDeKoning]

@helloitsaustin It's a great tool, but I used up almost my entire weekly limit casually working on a single slide deck (less than an hour on the 20X max plan) :(

[Jason de Koning 🇨🇦 @JasonDeKoning]

@OpenAI @Amgen @moderna_tx @AllenInstitute @thermofisher This looks exciting, but it's really disappointing to see this as a closed research preview. Why not make this freely available to academic scientists already paying for pro/max subscriptions?

[Jason de Koning 🇨🇦 @JasonDeKoning]

@MilkRoadAI Two Nobel-recognized researchers? LeCun has not won a Nobel prize (though he shared a Turing award - no shade intended)

[Jason de Koning 🇨🇦 @JasonDeKoning]

@chrisgpt Elon says many things. Whether the truth is among them is unclear.

[Chengxiang Qiu @CXchengxiangQIU]

New preprint! @JShendure @CXchengxiangQIU Can we learn regulatory grammars of human cell types we'll never be able to profile - by training on mouse development and transferring across 241 mammalian genomes?https://t.co/sWCWoAqJ2B

[Jason de Koning 🇨🇦 @JasonDeKoning]

@mgdurrant Yes! When?

[Jason de Koning 🇨🇦 @JasonDeKoning]

@DarioAmodei Bravo! It would be great if you could also keep academic scientists working in the public interest in mind for priority access. I promise, we'll put it to good use.

[Jason de Koning 🇨🇦 @JasonDeKoning]

@alexalbert__ Wow. ...I get the emphasis on cyber, but I hope @AnthropicAI will also consider academic scientists as a priority group for expanding (affordable) access ASAP.

[Jason de Koning 🇨🇦 @JasonDeKoning]

@Cappy_Nate I’m a computational biologist and am interested! I’m working on Bio x AI, health, genomics, etc.

[Jason de Koning 🇨🇦 @JasonDeKoning]

@bensig ..."Leeloo Dallas multipass", Milla??

[Jason de Koning 🇨🇦 @JasonDeKoning]

@bcherny Can you pls clarify if this a policy change since the Jan crackdown on OAuth mis/use with OpenCode, OpenClaw, etc., or is this just a notice that the previous policy will now be strictly enforced?

Are ocassional cron-based callouts to `claude -p` still kosher?

[Jason de Koning 🇨🇦 @JasonDeKoning]

@thsottiaux @OpenAICodexCli In the last 24 hours i've been intermittently getting garbled text from Codex using gpt-5.4 xhigh. I've never seen this before. Are you guys on this?

e.g.: "The current rer且 the ` will likely now run to completion; meanwhile I'm waiting on its artifact summary so below is notrə. Irotma: the last interrackh help【accd090000 No ops / no changes. obviator overlapping thrust just contd0 C no更. entered001 -; existing currently yes."

[Jason de Koning 🇨🇦 @JasonDeKoning]

@peterottsjo 👀 https://t.co/DsMEWH16Ad

[Greg Brockman @gdb]

$100 in Codex credits for college student in U.S. and Canada:

[Jason de Koning 🇨🇦 @JasonDeKoning]

@tszzl You must be trolling

[Jason de Koning 🇨🇦 @JasonDeKoning]

@amorriscode @tannerlinsley Need any scientist beta testers? I would love to give it a trial

[Jason de Koning 🇨🇦 @JasonDeKoning]

@MatthewBerman @nvidia @Dell Congrats!! Want. (For science purposes.)