Suo Yang

[Suo Yang @Jucember]

Congratulations Ying!

[Tibor Rohacs @RohacsTibor]

Cool paper by @ying_yin and Seok-Yong Lee, showing that inhibitors bind selectively to the desensitized state of the cold and menthol sensor TRPM8 #ionchannel, indicating overlapping mechanisms for desensitization and inhibition https://t.co/fd7VyNvdtc

[Nature Methods @naturemethods]

Out today from the Bartesaghi lab! nextPYP is a turn-key framework for single-particle cryo-ET that streamlines complex data analysis pipelines, from pre-processing of tilt series to high-resolution refinement, for efficient analysis of large datasets. https://t.co/ot2wR3wbFO

[bioRxiv Biophysics @biorxiv_biophys]

Structural dynamics at cytosolic inter-protomer interfaces control gating of a mammalian TRPM5 channel https://t.co/zy1069IqId #biorxiv_biophys

[YingYin @ying__yin]

Today another preprint from Lee lab @dukebiochem ⭐️Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2⭐️ Amazing work by Yang Suo
@Jucember, Nick Wright @nick_rite, mentor Seok-Yong, and the Im lab at LehighU. Congrats to all!!! https://t.co/QLzjcjQC2W

[Ali Punjani @a_punjani]

We show that 3DFlex learns multiple dimensions of flexibility in a tri-snRNP spliceosome complex, while maintaining detail in secondary structure elements that move 20Å+. On TRPV1 ion channel data, 3DFlex learns two kinds of coordinated bending of the soluble domains:
3/

[Jonathan Bouvette @CryoJB]

So I collected 1242 tilt series (+/- 36 degrees /w 3 deg increments) over the weekend using BISECT on Krios with K3.
Now let's get some structure!
Can't wait to share those scripts.
#CryoEM #teamtomo

[Nature Portfolio @NaturePortfolio]

A Nature paper reports the sharpest images yet obtained by using a method called single-particle cryo-EM. https://t.co/j0msdAsPFU

[bioRxiv @biorxivpreprint]

Brain Endothelial Cell TRPA1 Channels Initiate Neurovascular Coupling https://t.co/Fiy2JScaE6 #bioRxiv

[Duke Department of Biochemistry @dukebiochem]

Using #CryoEM, Alberto Bartesaghi, PhD, @thesilvalab @DukeU Biology & team discovered new regulation of protein production on cells Under #OxidativeStress. Read more https://t.co/fSuQQmewY2 @DukeMedSchool

[Xiao Fan @xiaofan_cryoEM]

Our new work is finally out!🍻 Extended from previous results, graphene grids are applied to establish a convenient workflow for cryo-EM analysis of liposome-embedded MPs. So many thanks to Nieng and Xia! More to be explored when everything back to normal
https://t.co/On0GIwJRKx

[Jenny van Asbeck - van der Wijst @JennyvAvdW]

Our collaborative review with @yifan_ucsf on TRPV channels is out in Protein Science
https://t.co/q1s5vq3f3Y

[David S. Goodsell 🏳️‍🌈 @dsgoodsell]

Coronavirus life cycle, with spikes being made in ER at top, viral replicases and double membrane vesicles at center, and budding viruses at the bottom. I'll be making a big file and a full description available @buildmodels in the near future.

[Aaron Owji @AaronOwji]

Check out our paper detailing the #cryoem structure of the Bestrophin 2 anion channel. We solved preferred orientation by adding amphipol to the final protein prep, resulting in 2.2A resolution. @Columbia @SEMC_NYSBC
https://t.co/kfU0VxSC3x

[Alexander Sobolevsky @AlexanderSobol6]

Structural and functional characterization of the bestrophin-2 anion channel. Amazing resolution! https://t.co/E1DPfa6Lx2

[NCCAT Info @NCCATinfo]

At #BPS20? Come by the exhibit hall to learn about the national #cryoEM service centers and the Transformative High Resolution Cryo-Electron Microscopy Program (https://t.co/OC1hdXHepn).

Booth 129 - @SLAClab #S2C2 @CryoEM_PNCC @NCCATinfo @NIH_CommonFund

[Wolf Lab @HiCryoEM]

Wow - barely 2 weeks and they synthesized the S protein gene, cloned expressed purified it, did #cryoEM using Warp and @cryosparc, receptor binding by Biacore AND cryoEM, wrote paper, pub online... did they ever sleep? Incredible! Congrats! (Note to self: need gene synthesizer)

[Protein Data Bank @PDBeurope]

The first 2019-nCoV #coronavirus structure of the main protease has been released today (6LU7). This is a result of a huge effort from Prof. Rao's group @ShanghaiTechUni. For more information on the structure and related data available in the PDB visit https://t.co/BMcExAzAr5

[NIE Yan(聶焱) @tsrabbit3]

The crystal structure of 2019-nCoV main protease is just another example of how fast a structure can be solved by crystallography (if all goes well). Also, Rao & Yang didn't recreate the wheel: they published the 1st crystal structure of SARS-CoV main protease in 2003 on PNAS.

[SchullerJM @SchullerJm]

I proudly present to you the segmented and coloured map of the awesome NDH-1MS complex. Read the paper here: https://t.co/56Iponsdlt Awesome cooperation with @NowaLab @TheKailaLab

[Hideaki E. Kato @emeKato]

new release3
6V11, EMD-21009: Lon Protease from Yersinia pestis
(CryoEM, 1.15Å)

https://t.co/Z9diiy2voG
https://t.co/0hEuBIoC8c
(Talos + K2, cryoSPARC)

Gabriel Lander lab.